In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus
Peptides with broad-spectrum antimicrobial activity, known as antimicrobial peptides, have been isolated from distinct organisms. This paper describes the in vitro evaluation of the cytotoxicity and antiviral activity of nine peptides with different structures and origins against herpes simplex virus type 1, human adenovirus respiratory strain, and rotavirus SA11. Most of the evaluated peptides presented antiviral activity but they were only active near cytotoxic concentrations. Nevertheless, these results seem promising, and further modifications on the peptide's structures may improve their selectivity and reduce their cytotoxicity.
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Instituto Oswaldo Cruz, Ministério da Saúde
2007
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oai:scielo:S0074-027620070004000072008-02-25In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirusCarriel-Gomes,Márcia CristinaKratz,Jadel MüllerBarracco,Margherita AnnaBachére,EvelyneBarardi,Célia Regina MonteSimões,Cláudia Maria Oliveira antimicrobial peptides antiviral activity herpesvirus adenovirus rotavirus Peptides with broad-spectrum antimicrobial activity, known as antimicrobial peptides, have been isolated from distinct organisms. This paper describes the in vitro evaluation of the cytotoxicity and antiviral activity of nine peptides with different structures and origins against herpes simplex virus type 1, human adenovirus respiratory strain, and rotavirus SA11. Most of the evaluated peptides presented antiviral activity but they were only active near cytotoxic concentrations. Nevertheless, these results seem promising, and further modifications on the peptide's structures may improve their selectivity and reduce their cytotoxicity.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.102 n.4 20072007-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000400007en10.1590/S0074-02762007005000028 |
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Carriel-Gomes,Márcia Cristina Kratz,Jadel Müller Barracco,Margherita Anna Bachére,Evelyne Barardi,Célia Regina Monte Simões,Cláudia Maria Oliveira |
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Carriel-Gomes,Márcia Cristina Kratz,Jadel Müller Barracco,Margherita Anna Bachére,Evelyne Barardi,Célia Regina Monte Simões,Cláudia Maria Oliveira In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus |
| author_facet |
Carriel-Gomes,Márcia Cristina Kratz,Jadel Müller Barracco,Margherita Anna Bachére,Evelyne Barardi,Célia Regina Monte Simões,Cláudia Maria Oliveira |
| author_sort |
Carriel-Gomes,Márcia Cristina |
| title |
In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus |
| title_short |
In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus |
| title_full |
In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus |
| title_fullStr |
In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus |
| title_full_unstemmed |
In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus |
| title_sort |
in vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus |
| description |
Peptides with broad-spectrum antimicrobial activity, known as antimicrobial peptides, have been isolated from distinct organisms. This paper describes the in vitro evaluation of the cytotoxicity and antiviral activity of nine peptides with different structures and origins against herpes simplex virus type 1, human adenovirus respiratory strain, and rotavirus SA11. Most of the evaluated peptides presented antiviral activity but they were only active near cytotoxic concentrations. Nevertheless, these results seem promising, and further modifications on the peptide's structures may improve their selectivity and reduce their cytotoxicity. |
| publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
| publishDate |
2007 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000400007 |
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