The effects of fluconazole and cytokines on human mononuclear cells
Candida infections are common infections and fluconazole is one of the most frequently administered antifungal agents in their treatment. The resistance developed against antifungal agents has necessitated the improvement of new treatments. This study focuses on the investigation of the effect of fluconazole and cytokines such as interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF) on chemokine production and anticandidal activity of human monocytes. In the study it was observed that GM-CSF caused an increase in candidacidal activity of monocytes. Anticandidal activity of GM-CSF + IFN-gamma combination was not found to be more effective than GM-CSF or IFN-gamma alone. The presence of cytokine and fluconazole caused an increase in the levels of CCL3 and CCL4 chemokines. Accordingly, it was considered that chemokines could contribute to the efficacy of fluconazole in C. albicans infections. Besides, in order to strengthen the immune system some cytokines might be used in addition to antifungal agents for the treatment.
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Instituto Oswaldo Cruz, Ministério da Saúde
2007
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oai:scielo:S0074-027620070002000012008-02-25The effects of fluconazole and cytokines on human mononuclear cellsFidan,IsilYuksel,SevgiImir,TurgutKalkanci,AyseKustimur,SemraIlhan,Mustafa N Candida albicans fluconazole cytokines chemokines Candida infections are common infections and fluconazole is one of the most frequently administered antifungal agents in their treatment. The resistance developed against antifungal agents has necessitated the improvement of new treatments. This study focuses on the investigation of the effect of fluconazole and cytokines such as interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF) on chemokine production and anticandidal activity of human monocytes. In the study it was observed that GM-CSF caused an increase in candidacidal activity of monocytes. Anticandidal activity of GM-CSF + IFN-gamma combination was not found to be more effective than GM-CSF or IFN-gamma alone. The presence of cytokine and fluconazole caused an increase in the levels of CCL3 and CCL4 chemokines. Accordingly, it was considered that chemokines could contribute to the efficacy of fluconazole in C. albicans infections. Besides, in order to strengthen the immune system some cytokines might be used in addition to antifungal agents for the treatment.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.102 n.2 20072007-03-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000200001en10.1590/S0074-02762007005000021 |
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Fidan,Isil Yuksel,Sevgi Imir,Turgut Kalkanci,Ayse Kustimur,Semra Ilhan,Mustafa N |
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Fidan,Isil Yuksel,Sevgi Imir,Turgut Kalkanci,Ayse Kustimur,Semra Ilhan,Mustafa N The effects of fluconazole and cytokines on human mononuclear cells |
author_facet |
Fidan,Isil Yuksel,Sevgi Imir,Turgut Kalkanci,Ayse Kustimur,Semra Ilhan,Mustafa N |
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Fidan,Isil |
title |
The effects of fluconazole and cytokines on human mononuclear cells |
title_short |
The effects of fluconazole and cytokines on human mononuclear cells |
title_full |
The effects of fluconazole and cytokines on human mononuclear cells |
title_fullStr |
The effects of fluconazole and cytokines on human mononuclear cells |
title_full_unstemmed |
The effects of fluconazole and cytokines on human mononuclear cells |
title_sort |
effects of fluconazole and cytokines on human mononuclear cells |
description |
Candida infections are common infections and fluconazole is one of the most frequently administered antifungal agents in their treatment. The resistance developed against antifungal agents has necessitated the improvement of new treatments. This study focuses on the investigation of the effect of fluconazole and cytokines such as interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF) on chemokine production and anticandidal activity of human monocytes. In the study it was observed that GM-CSF caused an increase in candidacidal activity of monocytes. Anticandidal activity of GM-CSF + IFN-gamma combination was not found to be more effective than GM-CSF or IFN-gamma alone. The presence of cytokine and fluconazole caused an increase in the levels of CCL3 and CCL4 chemokines. Accordingly, it was considered that chemokines could contribute to the efficacy of fluconazole in C. albicans infections. Besides, in order to strengthen the immune system some cytokines might be used in addition to antifungal agents for the treatment. |
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Instituto Oswaldo Cruz, Ministério da Saúde |
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2007 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000200001 |
work_keys_str_mv |
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