Lymphatic vessel contractile activity and intestinal inflammation

Edema is a consistent observation in inflamatory bowel disease (IBD), and immune responses are inevitable in inflammation. Because the lymphatic system is an integral part of both tissue fluid homeostasis and immune reactions, it is likely that lymphatics play a role in the complex etiology of IBD. Despite the consistent findings that the lymphatic system is altered during gastrointestinal inflammation, the majority of studies conducted on the disease only mention the lymphatic system in passing. The effects of inflammatory mediators on lymphatic vessel function also remain poorly defined, despite its essential role in immunity and prevention of tissue edema. Processes allowing effective lymph transport are altered during inflammation, however, the mode of alteration and reason why lymphatics are ineffective in inflammatory reactions need to be further investigated. In addition, these processes have not yet been examined in an appropriate animal model and little has been done using in vivo methods of investigation in any model of gastrointestinal inflammation. This paper reviews the role of the lymphatic system in intestinal inflammation, as well as the role of the inflammatory products in mediating lymphatic contractile function.

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Main Authors: Wu,Theresa F, MacNaughton,Wallace K, von der Weid,Pierre-Yves
Format: Digital revista
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2005
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900018
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spelling oai:scielo:S0074-027620050009000182005-06-14Lymphatic vessel contractile activity and intestinal inflammationWu,Theresa FMacNaughton,Wallace Kvon der Weid,Pierre-Yves lymphatic vessel lymphatic pumping inflammation Crohn's disease prostanoids edema Edema is a consistent observation in inflamatory bowel disease (IBD), and immune responses are inevitable in inflammation. Because the lymphatic system is an integral part of both tissue fluid homeostasis and immune reactions, it is likely that lymphatics play a role in the complex etiology of IBD. Despite the consistent findings that the lymphatic system is altered during gastrointestinal inflammation, the majority of studies conducted on the disease only mention the lymphatic system in passing. The effects of inflammatory mediators on lymphatic vessel function also remain poorly defined, despite its essential role in immunity and prevention of tissue edema. Processes allowing effective lymph transport are altered during inflammation, however, the mode of alteration and reason why lymphatics are ineffective in inflammatory reactions need to be further investigated. In addition, these processes have not yet been examined in an appropriate animal model and little has been done using in vivo methods of investigation in any model of gastrointestinal inflammation. This paper reviews the role of the lymphatic system in intestinal inflammation, as well as the role of the inflammatory products in mediating lymphatic contractile function.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.100 suppl.1 20052005-03-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900018en10.1590/S0074-02762005000900018
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country Brasil
countrycode BR
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region America del Sur
libraryname SciELO
language English
format Digital
author Wu,Theresa F
MacNaughton,Wallace K
von der Weid,Pierre-Yves
spellingShingle Wu,Theresa F
MacNaughton,Wallace K
von der Weid,Pierre-Yves
Lymphatic vessel contractile activity and intestinal inflammation
author_facet Wu,Theresa F
MacNaughton,Wallace K
von der Weid,Pierre-Yves
author_sort Wu,Theresa F
title Lymphatic vessel contractile activity and intestinal inflammation
title_short Lymphatic vessel contractile activity and intestinal inflammation
title_full Lymphatic vessel contractile activity and intestinal inflammation
title_fullStr Lymphatic vessel contractile activity and intestinal inflammation
title_full_unstemmed Lymphatic vessel contractile activity and intestinal inflammation
title_sort lymphatic vessel contractile activity and intestinal inflammation
description Edema is a consistent observation in inflamatory bowel disease (IBD), and immune responses are inevitable in inflammation. Because the lymphatic system is an integral part of both tissue fluid homeostasis and immune reactions, it is likely that lymphatics play a role in the complex etiology of IBD. Despite the consistent findings that the lymphatic system is altered during gastrointestinal inflammation, the majority of studies conducted on the disease only mention the lymphatic system in passing. The effects of inflammatory mediators on lymphatic vessel function also remain poorly defined, despite its essential role in immunity and prevention of tissue edema. Processes allowing effective lymph transport are altered during inflammation, however, the mode of alteration and reason why lymphatics are ineffective in inflammatory reactions need to be further investigated. In addition, these processes have not yet been examined in an appropriate animal model and little has been done using in vivo methods of investigation in any model of gastrointestinal inflammation. This paper reviews the role of the lymphatic system in intestinal inflammation, as well as the role of the inflammatory products in mediating lymphatic contractile function.
publisher Instituto Oswaldo Cruz, Ministério da Saúde
publishDate 2005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900018
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AT vonderweidpierreyves lymphaticvesselcontractileactivityandintestinalinflammation
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