CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis

CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis

The comprehension of the pathogenesis of Trypanosoma cruzi-elicited myocarditis is crucial to delineate new therapeutic strategies aiming to ameliorate the inflammation that leads to heart dysfunction, without hampering parasite control. The augmented expression of CCL5/RANTES and CCL3/MIP-1alpha, and their receptor CCR5, in the heart of T. cruzi-infected mice suggests a role for CC-chemokines and their receptors in the pathogenesis of T. cruzi-elicited myocarditis. Herein, we discuss our recent results using a CC-chemokine receptor inhibitor (Met-RANTES), showing the participation of CC-chemokines in T. cruzi infection and unraveling CC-chemokine receptors as an attractive therapeutic target for further evaluation in Chagas disease.

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Main Authors: Marino,APMP, Silva,AA, Santos,PVA, Pinto,LMO, Gazinelli,RT, Teixeira,MM, Lannes-Vieira,J
Format: Digital revista
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2005
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900015
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spelling oai:scielo:S0074-027620050009000152005-06-15CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditisMarino,APMPSilva,AASantos,PVAPinto,LMOGazinelli,RTTeixeira,MMLannes-Vieira,J Trypanosoma cruzi myocarditis CC-chemokines CC-chemokine receptors Met-RANTES The comprehension of the pathogenesis of Trypanosoma cruzi-elicited myocarditis is crucial to delineate new therapeutic strategies aiming to ameliorate the inflammation that leads to heart dysfunction, without hampering parasite control. The augmented expression of CCL5/RANTES and CCL3/MIP-1alpha, and their receptor CCR5, in the heart of T. cruzi-infected mice suggests a role for CC-chemokines and their receptors in the pathogenesis of T. cruzi-elicited myocarditis. Herein, we discuss our recent results using a CC-chemokine receptor inhibitor (Met-RANTES), showing the participation of CC-chemokines in T. cruzi infection and unraveling CC-chemokine receptors as an attractive therapeutic target for further evaluation in Chagas disease.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.100 suppl.1 20052005-03-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900015en10.1590/S0074-02762005000900015
institution SCIELO
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country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Marino,APMP
Silva,AA
Santos,PVA
Pinto,LMO
Gazinelli,RT
Teixeira,MM
Lannes-Vieira,J
spellingShingle Marino,APMP
Silva,AA
Santos,PVA
Pinto,LMO
Gazinelli,RT
Teixeira,MM
Lannes-Vieira,J
CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
author_facet Marino,APMP
Silva,AA
Santos,PVA
Pinto,LMO
Gazinelli,RT
Teixeira,MM
Lannes-Vieira,J
author_sort Marino,APMP
title CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
title_short CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
title_full CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
title_fullStr CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
title_full_unstemmed CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
title_sort cc-chemokine receptors: a potential therapeutic target for trypanosoma cruzi-elicited myocarditis
description The comprehension of the pathogenesis of Trypanosoma cruzi-elicited myocarditis is crucial to delineate new therapeutic strategies aiming to ameliorate the inflammation that leads to heart dysfunction, without hampering parasite control. The augmented expression of CCL5/RANTES and CCL3/MIP-1alpha, and their receptor CCR5, in the heart of T. cruzi-infected mice suggests a role for CC-chemokines and their receptors in the pathogenesis of T. cruzi-elicited myocarditis. Herein, we discuss our recent results using a CC-chemokine receptor inhibitor (Met-RANTES), showing the participation of CC-chemokines in T. cruzi infection and unraveling CC-chemokine receptors as an attractive therapeutic target for further evaluation in Chagas disease.
publisher Instituto Oswaldo Cruz, Ministério da Saúde
publishDate 2005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900015
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AT silvaaa ccchemokinereceptorsapotentialtherapeutictargetfortrypanosomacruzielicitedmyocarditis
AT santospva ccchemokinereceptorsapotentialtherapeutictargetfortrypanosomacruzielicitedmyocarditis
AT pintolmo ccchemokinereceptorsapotentialtherapeutictargetfortrypanosomacruzielicitedmyocarditis
AT gazinellirt ccchemokinereceptorsapotentialtherapeutictargetfortrypanosomacruzielicitedmyocarditis
AT teixeiramm ccchemokinereceptorsapotentialtherapeutictargetfortrypanosomacruzielicitedmyocarditis
AT lannesvieiraj ccchemokinereceptorsapotentialtherapeutictargetfortrypanosomacruzielicitedmyocarditis
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