Saponins from Swartzia langsdorffii: biological activities
The presence of saponins and the molluscicidal activity of the roots, leaves, seeds and fruits of Swartzia langsdorffii Raddi (Leguminosae) against Biomphalaria glabrata adults and eggs were investigated. The roots, seeds and fruits were macerated in 95% ethanol. These extracts exerted a significant molluscicidal activity against B. glabrata, up to a dilution of 100 mg/l. Four mixtures (A2, B2, C and D) of triterpenoid oleanane type saponins were chromatographically isolated from the seed and fruit extracts. Two known saponins (1 and 2) were identified as beta-D-glucopyranosyl-[alpha-L-rhamnopyranosyl-(1->3)- beta-D-glucuronopyranosyl-(1->3)]-3beta-hydroxyolean-12-ene-28 -oate, and beta-D-glucopyranosyl-(1->3)-beta-D-glucuronopyranosyl-(1 ->3)]-3beta-hydroxyolean-12-ene-28-oate, respectively. These two saponins were present in all the mixtures, together with other triterpenoid oleane type saponins, which were shown to be less polar, by reversed-phase HPLC. The saponin identifications were based on spectral evidence, including ¹H-¹H two-dimensional correlation spectroscopy, nuclear Overhauser and exchange spectroscopy, heteronuclear multiple quantum coherence, and heteronuclear multiple-bond connectivity experiments. The toxicity of S. langsdorffii saponins to non-target organisms was prescreened by the brine shrimp lethality test.
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Instituto Oswaldo Cruz, Ministério da Saúde
2003
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oai:scielo:S0074-027620030005000222003-09-09Saponins from Swartzia langsdorffii: biological activitiesMagalhães,Aderbal FariasTozzi,Ana Maria Goulart de AzevedoSantos,Celira CaparicaSerrano,Deborah ReginaZanotti-Magalhães,Eliana MariaMagalhães,Eva GonçalvesMagalhães,Luiz Augusto Swartzia langsdorffii Leguminosae chemotaxonomy saponins molluscicidal activity schistosomiasis Artemia salina The presence of saponins and the molluscicidal activity of the roots, leaves, seeds and fruits of Swartzia langsdorffii Raddi (Leguminosae) against Biomphalaria glabrata adults and eggs were investigated. The roots, seeds and fruits were macerated in 95% ethanol. These extracts exerted a significant molluscicidal activity against B. glabrata, up to a dilution of 100 mg/l. Four mixtures (A2, B2, C and D) of triterpenoid oleanane type saponins were chromatographically isolated from the seed and fruit extracts. Two known saponins (1 and 2) were identified as beta-D-glucopyranosyl-[alpha-L-rhamnopyranosyl-(1->3)- beta-D-glucuronopyranosyl-(1->3)]-3beta-hydroxyolean-12-ene-28 -oate, and beta-D-glucopyranosyl-(1->3)-beta-D-glucuronopyranosyl-(1 ->3)]-3beta-hydroxyolean-12-ene-28-oate, respectively. These two saponins were present in all the mixtures, together with other triterpenoid oleane type saponins, which were shown to be less polar, by reversed-phase HPLC. The saponin identifications were based on spectral evidence, including ¹H-¹H two-dimensional correlation spectroscopy, nuclear Overhauser and exchange spectroscopy, heteronuclear multiple quantum coherence, and heteronuclear multiple-bond connectivity experiments. The toxicity of S. langsdorffii saponins to non-target organisms was prescreened by the brine shrimp lethality test.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.98 n.5 20032003-07-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000500022en10.1590/S0074-02762003000500022 |
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Magalhães,Aderbal Farias Tozzi,Ana Maria Goulart de Azevedo Santos,Celira Caparica Serrano,Deborah Regina Zanotti-Magalhães,Eliana Maria Magalhães,Eva Gonçalves Magalhães,Luiz Augusto |
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Magalhães,Aderbal Farias Tozzi,Ana Maria Goulart de Azevedo Santos,Celira Caparica Serrano,Deborah Regina Zanotti-Magalhães,Eliana Maria Magalhães,Eva Gonçalves Magalhães,Luiz Augusto Saponins from Swartzia langsdorffii: biological activities |
author_facet |
Magalhães,Aderbal Farias Tozzi,Ana Maria Goulart de Azevedo Santos,Celira Caparica Serrano,Deborah Regina Zanotti-Magalhães,Eliana Maria Magalhães,Eva Gonçalves Magalhães,Luiz Augusto |
author_sort |
Magalhães,Aderbal Farias |
title |
Saponins from Swartzia langsdorffii: biological activities |
title_short |
Saponins from Swartzia langsdorffii: biological activities |
title_full |
Saponins from Swartzia langsdorffii: biological activities |
title_fullStr |
Saponins from Swartzia langsdorffii: biological activities |
title_full_unstemmed |
Saponins from Swartzia langsdorffii: biological activities |
title_sort |
saponins from swartzia langsdorffii: biological activities |
description |
The presence of saponins and the molluscicidal activity of the roots, leaves, seeds and fruits of Swartzia langsdorffii Raddi (Leguminosae) against Biomphalaria glabrata adults and eggs were investigated. The roots, seeds and fruits were macerated in 95% ethanol. These extracts exerted a significant molluscicidal activity against B. glabrata, up to a dilution of 100 mg/l. Four mixtures (A2, B2, C and D) of triterpenoid oleanane type saponins were chromatographically isolated from the seed and fruit extracts. Two known saponins (1 and 2) were identified as beta-D-glucopyranosyl-[alpha-L-rhamnopyranosyl-(1->3)- beta-D-glucuronopyranosyl-(1->3)]-3beta-hydroxyolean-12-ene-28 -oate, and beta-D-glucopyranosyl-(1->3)-beta-D-glucuronopyranosyl-(1 ->3)]-3beta-hydroxyolean-12-ene-28-oate, respectively. These two saponins were present in all the mixtures, together with other triterpenoid oleane type saponins, which were shown to be less polar, by reversed-phase HPLC. The saponin identifications were based on spectral evidence, including ¹H-¹H two-dimensional correlation spectroscopy, nuclear Overhauser and exchange spectroscopy, heteronuclear multiple quantum coherence, and heteronuclear multiple-bond connectivity experiments. The toxicity of S. langsdorffii saponins to non-target organisms was prescreened by the brine shrimp lethality test. |
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Instituto Oswaldo Cruz, Ministério da Saúde |
publishDate |
2003 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000500022 |
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