The impact of repeated treatment with praziquantel of schistosomiasis in children under six years of age living in an endemic area for Schistosoma haematobium infection
Praziquantel was given every eight weeks for two years to children aged under six years of age, living in a Schistosoma haematobium endemic area. Infection with S. haematobium and haematuria were examined in urine and antibody profiles (IgA, IgE, IgM, IgG1, IgG2, IgG3, and IgG4) against S. haematobium adult worm and egg antigens were determined from sera collected before each treatment. Chemotherapy reduced infection prevalence and mean intensity from 51.8% and 110 eggs per 10 ml urine, respectively, before starting re-treatment programme to very low levels thereafter. Praziquantel is not accumulated after periodic administration in children. Immunoglobulin levels change during the course of treatment with a shift towards 'protective' mechanisms. The significant changes noted in some individuals were the drop in 'blocking' IgG2 and IgG4 whereas the 'protecting' IgA and IgG1 levels increased. The antibody profiles in the rest of the children remained generally unchanged throughout the study and no haematuria was observed after the second treatment. The removal of worms before production of large number of eggs, prevented the children from developing morbidity.
Main Authors: | , , , , , , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Instituto Oswaldo Cruz, Ministério da Saúde
2001
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000900024 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S0074-02762001000900024 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S0074-027620010009000242001-10-03The impact of repeated treatment with praziquantel of schistosomiasis in children under six years of age living in an endemic area for Schistosoma haematobium infectionMduluza,TNdhlovu,PDMadziwa,TMMidzi,NZinyama,RTurner,CMRChandiwana,SKNyazema,NHagan,P Schistosoma haematobium praziquantel antibody profiles morbidity Praziquantel was given every eight weeks for two years to children aged under six years of age, living in a Schistosoma haematobium endemic area. Infection with S. haematobium and haematuria were examined in urine and antibody profiles (IgA, IgE, IgM, IgG1, IgG2, IgG3, and IgG4) against S. haematobium adult worm and egg antigens were determined from sera collected before each treatment. Chemotherapy reduced infection prevalence and mean intensity from 51.8% and 110 eggs per 10 ml urine, respectively, before starting re-treatment programme to very low levels thereafter. Praziquantel is not accumulated after periodic administration in children. Immunoglobulin levels change during the course of treatment with a shift towards 'protective' mechanisms. The significant changes noted in some individuals were the drop in 'blocking' IgG2 and IgG4 whereas the 'protecting' IgA and IgG1 levels increased. The antibody profiles in the rest of the children remained generally unchanged throughout the study and no haematuria was observed after the second treatment. The removal of worms before production of large number of eggs, prevented the children from developing morbidity.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.96 suppl.0 20012001-09-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000900024en10.1590/S0074-02762001000900024 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Mduluza,T Ndhlovu,PD Madziwa,TM Midzi,N Zinyama,R Turner,CMR Chandiwana,SK Nyazema,N Hagan,P |
spellingShingle |
Mduluza,T Ndhlovu,PD Madziwa,TM Midzi,N Zinyama,R Turner,CMR Chandiwana,SK Nyazema,N Hagan,P The impact of repeated treatment with praziquantel of schistosomiasis in children under six years of age living in an endemic area for Schistosoma haematobium infection |
author_facet |
Mduluza,T Ndhlovu,PD Madziwa,TM Midzi,N Zinyama,R Turner,CMR Chandiwana,SK Nyazema,N Hagan,P |
author_sort |
Mduluza,T |
title |
The impact of repeated treatment with praziquantel of schistosomiasis in children under six years of age living in an endemic area for Schistosoma haematobium infection |
title_short |
The impact of repeated treatment with praziquantel of schistosomiasis in children under six years of age living in an endemic area for Schistosoma haematobium infection |
title_full |
The impact of repeated treatment with praziquantel of schistosomiasis in children under six years of age living in an endemic area for Schistosoma haematobium infection |
title_fullStr |
The impact of repeated treatment with praziquantel of schistosomiasis in children under six years of age living in an endemic area for Schistosoma haematobium infection |
title_full_unstemmed |
The impact of repeated treatment with praziquantel of schistosomiasis in children under six years of age living in an endemic area for Schistosoma haematobium infection |
title_sort |
impact of repeated treatment with praziquantel of schistosomiasis in children under six years of age living in an endemic area for schistosoma haematobium infection |
description |
Praziquantel was given every eight weeks for two years to children aged under six years of age, living in a Schistosoma haematobium endemic area. Infection with S. haematobium and haematuria were examined in urine and antibody profiles (IgA, IgE, IgM, IgG1, IgG2, IgG3, and IgG4) against S. haematobium adult worm and egg antigens were determined from sera collected before each treatment. Chemotherapy reduced infection prevalence and mean intensity from 51.8% and 110 eggs per 10 ml urine, respectively, before starting re-treatment programme to very low levels thereafter. Praziquantel is not accumulated after periodic administration in children. Immunoglobulin levels change during the course of treatment with a shift towards 'protective' mechanisms. The significant changes noted in some individuals were the drop in 'blocking' IgG2 and IgG4 whereas the 'protecting' IgA and IgG1 levels increased. The antibody profiles in the rest of the children remained generally unchanged throughout the study and no haematuria was observed after the second treatment. The removal of worms before production of large number of eggs, prevented the children from developing morbidity. |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
publishDate |
2001 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000900024 |
work_keys_str_mv |
AT mduluzat theimpactofrepeatedtreatmentwithpraziquantelofschistosomiasisinchildrenundersixyearsofagelivinginanendemicareaforschistosomahaematobiuminfection AT ndhlovupd theimpactofrepeatedtreatmentwithpraziquantelofschistosomiasisinchildrenundersixyearsofagelivinginanendemicareaforschistosomahaematobiuminfection AT madziwatm theimpactofrepeatedtreatmentwithpraziquantelofschistosomiasisinchildrenundersixyearsofagelivinginanendemicareaforschistosomahaematobiuminfection AT midzin theimpactofrepeatedtreatmentwithpraziquantelofschistosomiasisinchildrenundersixyearsofagelivinginanendemicareaforschistosomahaematobiuminfection AT zinyamar theimpactofrepeatedtreatmentwithpraziquantelofschistosomiasisinchildrenundersixyearsofagelivinginanendemicareaforschistosomahaematobiuminfection AT turnercmr theimpactofrepeatedtreatmentwithpraziquantelofschistosomiasisinchildrenundersixyearsofagelivinginanendemicareaforschistosomahaematobiuminfection AT chandiwanask theimpactofrepeatedtreatmentwithpraziquantelofschistosomiasisinchildrenundersixyearsofagelivinginanendemicareaforschistosomahaematobiuminfection AT nyazeman theimpactofrepeatedtreatmentwithpraziquantelofschistosomiasisinchildrenundersixyearsofagelivinginanendemicareaforschistosomahaematobiuminfection AT haganp theimpactofrepeatedtreatmentwithpraziquantelofschistosomiasisinchildrenundersixyearsofagelivinginanendemicareaforschistosomahaematobiuminfection AT mduluzat impactofrepeatedtreatmentwithpraziquantelofschistosomiasisinchildrenundersixyearsofagelivinginanendemicareaforschistosomahaematobiuminfection AT ndhlovupd impactofrepeatedtreatmentwithpraziquantelofschistosomiasisinchildrenundersixyearsofagelivinginanendemicareaforschistosomahaematobiuminfection AT madziwatm impactofrepeatedtreatmentwithpraziquantelofschistosomiasisinchildrenundersixyearsofagelivinginanendemicareaforschistosomahaematobiuminfection AT midzin impactofrepeatedtreatmentwithpraziquantelofschistosomiasisinchildrenundersixyearsofagelivinginanendemicareaforschistosomahaematobiuminfection AT zinyamar impactofrepeatedtreatmentwithpraziquantelofschistosomiasisinchildrenundersixyearsofagelivinginanendemicareaforschistosomahaematobiuminfection AT turnercmr impactofrepeatedtreatmentwithpraziquantelofschistosomiasisinchildrenundersixyearsofagelivinginanendemicareaforschistosomahaematobiuminfection AT chandiwanask impactofrepeatedtreatmentwithpraziquantelofschistosomiasisinchildrenundersixyearsofagelivinginanendemicareaforschistosomahaematobiuminfection AT nyazeman impactofrepeatedtreatmentwithpraziquantelofschistosomiasisinchildrenundersixyearsofagelivinginanendemicareaforschistosomahaematobiuminfection AT haganp impactofrepeatedtreatmentwithpraziquantelofschistosomiasisinchildrenundersixyearsofagelivinginanendemicareaforschistosomahaematobiuminfection |
_version_ |
1756383404605046784 |