Efficacy of ivermectin against the bloodsucking insect, Rhodnius prolixus (Hemiptera, Triatominae)

Ivermectin (0.2 mg/kg body weight) caused a high mortality in nymphs and adults of Rhodnius prolixus following a single meal in mice sub-cutaneously injected with the drug. This effect was more evident in nymphs of 1st-and 2nd-instar than in older nymphs and adults. Third-instar nymphs presented a high mortality when fed on mice treated with ivermectin 24 and 48 hours previously, while mortality was significantly reduced in nymphs fed on mice treated 72 hours before. Surviving 3rd-instar nymphs did not molt. When adult females were fed once on mice treated for 24 hours with ivermectin there was a considerable reduction in egg production. This inhibition was not reversed by a second feeding on normal mice. We concluded that sub-lethal doses of ivermectin caused toxic effects interfering in the neuro-endocrine control of development and reproduction of this bloodsucking insect.

Saved in:
Bibliographic Details
Main Authors: Azambuja,Patricia de, Gomes,José Eugenio P. Lima, Lopes,Fernando, Garcia,Eloi S.
Format: Digital revista
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 1985
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761985000400009
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:scielo:S0074-02761985000400009
record_format ojs
spelling oai:scielo:S0074-027619850004000092009-07-02Efficacy of ivermectin against the bloodsucking insect, Rhodnius prolixus (Hemiptera, Triatominae)Azambuja,Patricia deGomes,José Eugenio P. LimaLopes,FernandoGarcia,Eloi S. ivermectin Rhodnius prolixus Hemiptera insect development insect reproduction Ivermectin (0.2 mg/kg body weight) caused a high mortality in nymphs and adults of Rhodnius prolixus following a single meal in mice sub-cutaneously injected with the drug. This effect was more evident in nymphs of 1st-and 2nd-instar than in older nymphs and adults. Third-instar nymphs presented a high mortality when fed on mice treated with ivermectin 24 and 48 hours previously, while mortality was significantly reduced in nymphs fed on mice treated 72 hours before. Surviving 3rd-instar nymphs did not molt. When adult females were fed once on mice treated for 24 hours with ivermectin there was a considerable reduction in egg production. This inhibition was not reversed by a second feeding on normal mice. We concluded that sub-lethal doses of ivermectin caused toxic effects interfering in the neuro-endocrine control of development and reproduction of this bloodsucking insect.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.80 n.4 19851985-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761985000400009en10.1590/S0074-02761985000400009
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Azambuja,Patricia de
Gomes,José Eugenio P. Lima
Lopes,Fernando
Garcia,Eloi S.
spellingShingle Azambuja,Patricia de
Gomes,José Eugenio P. Lima
Lopes,Fernando
Garcia,Eloi S.
Efficacy of ivermectin against the bloodsucking insect, Rhodnius prolixus (Hemiptera, Triatominae)
author_facet Azambuja,Patricia de
Gomes,José Eugenio P. Lima
Lopes,Fernando
Garcia,Eloi S.
author_sort Azambuja,Patricia de
title Efficacy of ivermectin against the bloodsucking insect, Rhodnius prolixus (Hemiptera, Triatominae)
title_short Efficacy of ivermectin against the bloodsucking insect, Rhodnius prolixus (Hemiptera, Triatominae)
title_full Efficacy of ivermectin against the bloodsucking insect, Rhodnius prolixus (Hemiptera, Triatominae)
title_fullStr Efficacy of ivermectin against the bloodsucking insect, Rhodnius prolixus (Hemiptera, Triatominae)
title_full_unstemmed Efficacy of ivermectin against the bloodsucking insect, Rhodnius prolixus (Hemiptera, Triatominae)
title_sort efficacy of ivermectin against the bloodsucking insect, rhodnius prolixus (hemiptera, triatominae)
description Ivermectin (0.2 mg/kg body weight) caused a high mortality in nymphs and adults of Rhodnius prolixus following a single meal in mice sub-cutaneously injected with the drug. This effect was more evident in nymphs of 1st-and 2nd-instar than in older nymphs and adults. Third-instar nymphs presented a high mortality when fed on mice treated with ivermectin 24 and 48 hours previously, while mortality was significantly reduced in nymphs fed on mice treated 72 hours before. Surviving 3rd-instar nymphs did not molt. When adult females were fed once on mice treated for 24 hours with ivermectin there was a considerable reduction in egg production. This inhibition was not reversed by a second feeding on normal mice. We concluded that sub-lethal doses of ivermectin caused toxic effects interfering in the neuro-endocrine control of development and reproduction of this bloodsucking insect.
publisher Instituto Oswaldo Cruz, Ministério da Saúde
publishDate 1985
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761985000400009
work_keys_str_mv AT azambujapatriciade efficacyofivermectinagainstthebloodsuckinginsectrhodniusprolixushemipteratriatominae
AT gomesjoseeugenioplima efficacyofivermectinagainstthebloodsuckinginsectrhodniusprolixushemipteratriatominae
AT lopesfernando efficacyofivermectinagainstthebloodsuckinginsectrhodniusprolixushemipteratriatominae
AT garciaelois efficacyofivermectinagainstthebloodsuckinginsectrhodniusprolixushemipteratriatominae
_version_ 1756382987193155584