Lymph node cell responsiveness in BALB/C mice infected with Leishmania mexicana

Lymph node cell responsiveness in BALB/C mice infected with Leishmania mexicana

In the present study we measured the blastogenic response of lymph node cells from BALB/c mice infected with Leishmania mexicana throughout the course of infection. Results showed that infected mice displayed normal blastogenic responses in the lymph nodes until twenty weeks of infection. Thereafter, there was a gradual suppression. Comparison of the immunoresponsiveness in the spleen and lymph nodes, revealed normal responses in the lymph nodes several weeks after suppression in the spleen had occurred. Suppression of blastogenic responses in the lymph nodes was related to an adherent macrophage-like cell which actively suppressed normal proliferative responses to mitogens.

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Main Authors: Pérez,Hilda A., Bolívar,José
Format: Digital revista
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 1985
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761985000200002
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spelling oai:scielo:S0074-027619850002000022009-08-07Lymph node cell responsiveness in BALB/C mice infected with Leishmania mexicanaPérez,Hilda A.Bolívar,JoséIn the present study we measured the blastogenic response of lymph node cells from BALB/c mice infected with Leishmania mexicana throughout the course of infection. Results showed that infected mice displayed normal blastogenic responses in the lymph nodes until twenty weeks of infection. Thereafter, there was a gradual suppression. Comparison of the immunoresponsiveness in the spleen and lymph nodes, revealed normal responses in the lymph nodes several weeks after suppression in the spleen had occurred. Suppression of blastogenic responses in the lymph nodes was related to an adherent macrophage-like cell which actively suppressed normal proliferative responses to mitogens.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.80 n.2 19851985-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761985000200002en10.1590/S0074-02761985000200002
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Pérez,Hilda A.
Bolívar,José
spellingShingle Pérez,Hilda A.
Bolívar,José
Lymph node cell responsiveness in BALB/C mice infected with Leishmania mexicana
author_facet Pérez,Hilda A.
Bolívar,José
author_sort Pérez,Hilda A.
title Lymph node cell responsiveness in BALB/C mice infected with Leishmania mexicana
title_short Lymph node cell responsiveness in BALB/C mice infected with Leishmania mexicana
title_full Lymph node cell responsiveness in BALB/C mice infected with Leishmania mexicana
title_fullStr Lymph node cell responsiveness in BALB/C mice infected with Leishmania mexicana
title_full_unstemmed Lymph node cell responsiveness in BALB/C mice infected with Leishmania mexicana
title_sort lymph node cell responsiveness in balb/c mice infected with leishmania mexicana
description In the present study we measured the blastogenic response of lymph node cells from BALB/c mice infected with Leishmania mexicana throughout the course of infection. Results showed that infected mice displayed normal blastogenic responses in the lymph nodes until twenty weeks of infection. Thereafter, there was a gradual suppression. Comparison of the immunoresponsiveness in the spleen and lymph nodes, revealed normal responses in the lymph nodes several weeks after suppression in the spleen had occurred. Suppression of blastogenic responses in the lymph nodes was related to an adherent macrophage-like cell which actively suppressed normal proliferative responses to mitogens.
publisher Instituto Oswaldo Cruz, Ministério da Saúde
publishDate 1985
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761985000200002
work_keys_str_mv AT perezhildaa lymphnodecellresponsivenessinbalbcmiceinfectedwithleishmaniamexicana
AT bolivarjose lymphnodecellresponsivenessinbalbcmiceinfectedwithleishmaniamexicana
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