Lymph node cell responsiveness in BALB/C mice infected with Leishmania mexicana
In the present study we measured the blastogenic response of lymph node cells from BALB/c mice infected with Leishmania mexicana throughout the course of infection. Results showed that infected mice displayed normal blastogenic responses in the lymph nodes until twenty weeks of infection. Thereafter, there was a gradual suppression. Comparison of the immunoresponsiveness in the spleen and lymph nodes, revealed normal responses in the lymph nodes several weeks after suppression in the spleen had occurred. Suppression of blastogenic responses in the lymph nodes was related to an adherent macrophage-like cell which actively suppressed normal proliferative responses to mitogens.
Main Authors: | , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Instituto Oswaldo Cruz, Ministério da Saúde
1985
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761985000200002 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S0074-02761985000200002 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S0074-027619850002000022009-08-07Lymph node cell responsiveness in BALB/C mice infected with Leishmania mexicanaPérez,Hilda A.Bolívar,JoséIn the present study we measured the blastogenic response of lymph node cells from BALB/c mice infected with Leishmania mexicana throughout the course of infection. Results showed that infected mice displayed normal blastogenic responses in the lymph nodes until twenty weeks of infection. Thereafter, there was a gradual suppression. Comparison of the immunoresponsiveness in the spleen and lymph nodes, revealed normal responses in the lymph nodes several weeks after suppression in the spleen had occurred. Suppression of blastogenic responses in the lymph nodes was related to an adherent macrophage-like cell which actively suppressed normal proliferative responses to mitogens.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.80 n.2 19851985-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761985000200002en10.1590/S0074-02761985000200002 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Pérez,Hilda A. Bolívar,José |
spellingShingle |
Pérez,Hilda A. Bolívar,José Lymph node cell responsiveness in BALB/C mice infected with Leishmania mexicana |
author_facet |
Pérez,Hilda A. Bolívar,José |
author_sort |
Pérez,Hilda A. |
title |
Lymph node cell responsiveness in BALB/C mice infected with Leishmania mexicana |
title_short |
Lymph node cell responsiveness in BALB/C mice infected with Leishmania mexicana |
title_full |
Lymph node cell responsiveness in BALB/C mice infected with Leishmania mexicana |
title_fullStr |
Lymph node cell responsiveness in BALB/C mice infected with Leishmania mexicana |
title_full_unstemmed |
Lymph node cell responsiveness in BALB/C mice infected with Leishmania mexicana |
title_sort |
lymph node cell responsiveness in balb/c mice infected with leishmania mexicana |
description |
In the present study we measured the blastogenic response of lymph node cells from BALB/c mice infected with Leishmania mexicana throughout the course of infection. Results showed that infected mice displayed normal blastogenic responses in the lymph nodes until twenty weeks of infection. Thereafter, there was a gradual suppression. Comparison of the immunoresponsiveness in the spleen and lymph nodes, revealed normal responses in the lymph nodes several weeks after suppression in the spleen had occurred. Suppression of blastogenic responses in the lymph nodes was related to an adherent macrophage-like cell which actively suppressed normal proliferative responses to mitogens. |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
publishDate |
1985 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761985000200002 |
work_keys_str_mv |
AT perezhildaa lymphnodecellresponsivenessinbalbcmiceinfectedwithleishmaniamexicana AT bolivarjose lymphnodecellresponsivenessinbalbcmiceinfectedwithleishmaniamexicana |
_version_ |
1756382981008654336 |