Statin Treatments And Dosages In Children With Familial Hypercholesterolemia: Meta-Analysis
Abstract Background: Children with familial hypercholesterolemia may develop early endothelial damage leading to a high risk for the development of cardiovascular disease (CVD). Statins have been shown to be effective in lowering LDL cholesterol levels and cardiovascular events in adults. The effect of statin treatment in the pediatric population is not clearly demonstrated. Objective: To systematically review the literature to evaluate the effects of different statins and dosages in total cholesterol levels in children and adolescents with familial hypercholesterolemia. We also aimed to evaluate statin safety in this group. Methods: PubMed, EMBASE, Bireme, Web of Science, Cochrane Library, SciELO and LILACS databases, were searched for articles published from inception until February 2016. Two independent reviewers performed the quality assessment of the included studies. We performed a meta-analysis with random effects and inverse variance, and subgroup analyses were performed. Results: Ten trials involving a total of 1543 patients met the inclusion criteria. Our study showed reductions in cholesterol levels according to the intensity of statin doses (high, intermediate and low): (-104.61 mg/dl, -67.60 mg/dl, -56.96 mg/dl) and in the low-density lipoprotein cholesterol level: [-105.03 mg/dl (95% CI -115.76, -94.30), I2 19.2%], [-67.85 mg/dl (95% CI -83.36, -52.35), I2 99.8%], [-58.97 mg/dl (95% CI -67.83, -50.11), I2 93.8%. The duration of statin therapy in the studies ranged from 8 to 104 weeks, precluding conclusions about long-term effects. Conclusion: Statin treatment is efficient in lowering lipids in children with FH. There is need of large, long-term and randomized controlled trials to establish the long-term safety of statins.
Main Authors: | , , , , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira de Cardiologia - SBC
2018
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018001800810 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S0066-782X2018001800810 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S0066-782X20180018008102018-11-27Statin Treatments And Dosages In Children With Familial Hypercholesterolemia: Meta-AnalysisRadaelli,GracianeSausen,GrasieleCesa,Claudia CiceriSantos,Francisco de SouzaPortal,Vera LuciaNeyeloff,Jeruza LavanholiPellanda,Lucia Campos Statins Hydroxymethylglutaryl-CoA Reductase Inhibitors Hypercholesterolemia Type II/genetic Children Meta-Analysis Abstract Background: Children with familial hypercholesterolemia may develop early endothelial damage leading to a high risk for the development of cardiovascular disease (CVD). Statins have been shown to be effective in lowering LDL cholesterol levels and cardiovascular events in adults. The effect of statin treatment in the pediatric population is not clearly demonstrated. Objective: To systematically review the literature to evaluate the effects of different statins and dosages in total cholesterol levels in children and adolescents with familial hypercholesterolemia. We also aimed to evaluate statin safety in this group. Methods: PubMed, EMBASE, Bireme, Web of Science, Cochrane Library, SciELO and LILACS databases, were searched for articles published from inception until February 2016. Two independent reviewers performed the quality assessment of the included studies. We performed a meta-analysis with random effects and inverse variance, and subgroup analyses were performed. Results: Ten trials involving a total of 1543 patients met the inclusion criteria. Our study showed reductions in cholesterol levels according to the intensity of statin doses (high, intermediate and low): (-104.61 mg/dl, -67.60 mg/dl, -56.96 mg/dl) and in the low-density lipoprotein cholesterol level: [-105.03 mg/dl (95% CI -115.76, -94.30), I2 19.2%], [-67.85 mg/dl (95% CI -83.36, -52.35), I2 99.8%], [-58.97 mg/dl (95% CI -67.83, -50.11), I2 93.8%. The duration of statin therapy in the studies ranged from 8 to 104 weeks, precluding conclusions about long-term effects. Conclusion: Statin treatment is efficient in lowering lipids in children with FH. There is need of large, long-term and randomized controlled trials to establish the long-term safety of statins.info:eu-repo/semantics/openAccessSociedade Brasileira de Cardiologia - SBCArquivos Brasileiros de Cardiologia v.111 n.6 20182018-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018001800810en10.5935/abc.20180180 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Radaelli,Graciane Sausen,Grasiele Cesa,Claudia Ciceri Santos,Francisco de Souza Portal,Vera Lucia Neyeloff,Jeruza Lavanholi Pellanda,Lucia Campos |
spellingShingle |
Radaelli,Graciane Sausen,Grasiele Cesa,Claudia Ciceri Santos,Francisco de Souza Portal,Vera Lucia Neyeloff,Jeruza Lavanholi Pellanda,Lucia Campos Statin Treatments And Dosages In Children With Familial Hypercholesterolemia: Meta-Analysis |
author_facet |
Radaelli,Graciane Sausen,Grasiele Cesa,Claudia Ciceri Santos,Francisco de Souza Portal,Vera Lucia Neyeloff,Jeruza Lavanholi Pellanda,Lucia Campos |
author_sort |
Radaelli,Graciane |
title |
Statin Treatments And Dosages In Children With Familial Hypercholesterolemia: Meta-Analysis |
title_short |
Statin Treatments And Dosages In Children With Familial Hypercholesterolemia: Meta-Analysis |
title_full |
Statin Treatments And Dosages In Children With Familial Hypercholesterolemia: Meta-Analysis |
title_fullStr |
Statin Treatments And Dosages In Children With Familial Hypercholesterolemia: Meta-Analysis |
title_full_unstemmed |
Statin Treatments And Dosages In Children With Familial Hypercholesterolemia: Meta-Analysis |
title_sort |
statin treatments and dosages in children with familial hypercholesterolemia: meta-analysis |
description |
Abstract Background: Children with familial hypercholesterolemia may develop early endothelial damage leading to a high risk for the development of cardiovascular disease (CVD). Statins have been shown to be effective in lowering LDL cholesterol levels and cardiovascular events in adults. The effect of statin treatment in the pediatric population is not clearly demonstrated. Objective: To systematically review the literature to evaluate the effects of different statins and dosages in total cholesterol levels in children and adolescents with familial hypercholesterolemia. We also aimed to evaluate statin safety in this group. Methods: PubMed, EMBASE, Bireme, Web of Science, Cochrane Library, SciELO and LILACS databases, were searched for articles published from inception until February 2016. Two independent reviewers performed the quality assessment of the included studies. We performed a meta-analysis with random effects and inverse variance, and subgroup analyses were performed. Results: Ten trials involving a total of 1543 patients met the inclusion criteria. Our study showed reductions in cholesterol levels according to the intensity of statin doses (high, intermediate and low): (-104.61 mg/dl, -67.60 mg/dl, -56.96 mg/dl) and in the low-density lipoprotein cholesterol level: [-105.03 mg/dl (95% CI -115.76, -94.30), I2 19.2%], [-67.85 mg/dl (95% CI -83.36, -52.35), I2 99.8%], [-58.97 mg/dl (95% CI -67.83, -50.11), I2 93.8%. The duration of statin therapy in the studies ranged from 8 to 104 weeks, precluding conclusions about long-term effects. Conclusion: Statin treatment is efficient in lowering lipids in children with FH. There is need of large, long-term and randomized controlled trials to establish the long-term safety of statins. |
publisher |
Sociedade Brasileira de Cardiologia - SBC |
publishDate |
2018 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018001800810 |
work_keys_str_mv |
AT radaelligraciane statintreatmentsanddosagesinchildrenwithfamilialhypercholesterolemiametaanalysis AT sausengrasiele statintreatmentsanddosagesinchildrenwithfamilialhypercholesterolemiametaanalysis AT cesaclaudiaciceri statintreatmentsanddosagesinchildrenwithfamilialhypercholesterolemiametaanalysis AT santosfranciscodesouza statintreatmentsanddosagesinchildrenwithfamilialhypercholesterolemiametaanalysis AT portalveralucia statintreatmentsanddosagesinchildrenwithfamilialhypercholesterolemiametaanalysis AT neyeloffjeruzalavanholi statintreatmentsanddosagesinchildrenwithfamilialhypercholesterolemiametaanalysis AT pellandaluciacampos statintreatmentsanddosagesinchildrenwithfamilialhypercholesterolemiametaanalysis |
_version_ |
1756382104271192064 |