Jabuticaba-Induced Endothelium-Independent Vasodilating Effect on Isolated Arteries

Abstract Background: Despite the important biological effects of jabuticaba, its actions on the cardiovascular system have not been clarified. Objectives: To determine the effects of jabuticaba hydroalcoholic extract (JHE) on vascular smooth muscle (VSM) of isolated arteries. Methods: Endothelium-denuded aortic rings of rats were mounted in isolated organ bath to record isometric tension. The relaxant effect of JHE and the influence of K+ channels and Ca2+ intra- and extracellular sources on JHE-stimulated response were assessed. Results: Arteries pre-contracted with phenylephrine showed concentration-dependent relaxation (0.380 to 1.92 mg/mL). Treatment with K+ channel blockers (tetraethyl-ammonium, glibenclamide, 4-aminopyridine) hindered relaxation due to JHE. In addition, phenylephrine-stimulated contraction was hindered by previous treatment with JHE. Inhibition of sarcoplasmic reticulum Ca2+ ATPase did not change relaxation due to JHE. In addition, JHE inhibited the contraction caused by Ca2+ influx stimulated by phenylephrine and KCl (75 mM). Conclusion: JHE induces endothelium-independent vasodilation. Activation of K+ channels and inhibition of Ca2+ influx through the membrane are involved in the JHE relaxant effect.

Bibliographic Details

Main Authors:	Andrade,Daniela Medeiros Lobo de, Borges,Leonardo Luis, Torres,Ieda Maria Sapateiro, Conceição,Edemilson Cardoso da, Rocha,Matheus Lavorenti
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Cardiologia - SBC 2016
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016004200223
Tags:	Add Tag No Tags, Be the first to tag this record!