Cardiac Damage from Chronic Use of Chloroquine: A Case Report and Review of the Literature
Chloroquine has been widely used in rheumatological treatment, but potential severe side effects require careful follow-up. Cardiac damage is not a common consequence, but its clinical relevance has not yet been described. We report the case of a 58-year-old woman with rheumatoid arthritis, in whom chronic chloroquine use resulted in major irreversible cardiac damage. She presented with syncopal episodes due to complete atrioventricular block confirmed by electrophysiological study whose changes were concluded to be irreversible and a permanent pacemaker was indicated. Endomyocardial biopsy was also performed to search for histopathological and ultrastructural cardiac damage. We also reviewed the 22 cases of chloroquine-induced cardiopathy described to date as well as its pathophysiology.
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedade Brasileira de Cardiologia - SBC
2002
|
| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2002001000009 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
oai:scielo:S0066-782X2002001000009 |
|---|---|
| record_format |
ojs |
| spelling |
oai:scielo:S0066-782X20020010000092002-08-01Cardiac Damage from Chronic Use of Chloroquine: A Case Report and Review of the LiteratureTeixeira,Ricardo AlkmimMartinelli Filho,MartinoBenvenuti,Luiz AlbertoCosta,RobertoPedrosa,Anísio A.Nishióka,Silvana A. D.Chloroquine has been widely used in rheumatological treatment, but potential severe side effects require careful follow-up. Cardiac damage is not a common consequence, but its clinical relevance has not yet been described. We report the case of a 58-year-old woman with rheumatoid arthritis, in whom chronic chloroquine use resulted in major irreversible cardiac damage. She presented with syncopal episodes due to complete atrioventricular block confirmed by electrophysiological study whose changes were concluded to be irreversible and a permanent pacemaker was indicated. Endomyocardial biopsy was also performed to search for histopathological and ultrastructural cardiac damage. We also reviewed the 22 cases of chloroquine-induced cardiopathy described to date as well as its pathophysiology.info:eu-repo/semantics/openAccessSociedade Brasileira de Cardiologia - SBCArquivos Brasileiros de Cardiologia v.79 n.1 20022002-07-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2002001000009en10.1590/S0066-782X2002001000009 |
| institution |
SCIELO |
| collection |
OJS |
| country |
Brasil |
| countrycode |
BR |
| component |
Revista |
| access |
En linea |
| databasecode |
rev-scielo-br |
| tag |
revista |
| region |
America del Sur |
| libraryname |
SciELO |
| language |
English |
| format |
Digital |
| author |
Teixeira,Ricardo Alkmim Martinelli Filho,Martino Benvenuti,Luiz Alberto Costa,Roberto Pedrosa,Anísio A. Nishióka,Silvana A. D. |
| spellingShingle |
Teixeira,Ricardo Alkmim Martinelli Filho,Martino Benvenuti,Luiz Alberto Costa,Roberto Pedrosa,Anísio A. Nishióka,Silvana A. D. Cardiac Damage from Chronic Use of Chloroquine: A Case Report and Review of the Literature |
| author_facet |
Teixeira,Ricardo Alkmim Martinelli Filho,Martino Benvenuti,Luiz Alberto Costa,Roberto Pedrosa,Anísio A. Nishióka,Silvana A. D. |
| author_sort |
Teixeira,Ricardo Alkmim |
| title |
Cardiac Damage from Chronic Use of Chloroquine: A Case Report and Review of the Literature |
| title_short |
Cardiac Damage from Chronic Use of Chloroquine: A Case Report and Review of the Literature |
| title_full |
Cardiac Damage from Chronic Use of Chloroquine: A Case Report and Review of the Literature |
| title_fullStr |
Cardiac Damage from Chronic Use of Chloroquine: A Case Report and Review of the Literature |
| title_full_unstemmed |
Cardiac Damage from Chronic Use of Chloroquine: A Case Report and Review of the Literature |
| title_sort |
cardiac damage from chronic use of chloroquine: a case report and review of the literature |
| description |
Chloroquine has been widely used in rheumatological treatment, but potential severe side effects require careful follow-up. Cardiac damage is not a common consequence, but its clinical relevance has not yet been described. We report the case of a 58-year-old woman with rheumatoid arthritis, in whom chronic chloroquine use resulted in major irreversible cardiac damage. She presented with syncopal episodes due to complete atrioventricular block confirmed by electrophysiological study whose changes were concluded to be irreversible and a permanent pacemaker was indicated. Endomyocardial biopsy was also performed to search for histopathological and ultrastructural cardiac damage. We also reviewed the 22 cases of chloroquine-induced cardiopathy described to date as well as its pathophysiology. |
| publisher |
Sociedade Brasileira de Cardiologia - SBC |
| publishDate |
2002 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2002001000009 |
| work_keys_str_mv |
AT teixeiraricardoalkmim cardiacdamagefromchronicuseofchloroquineacasereportandreviewoftheliterature AT martinellifilhomartino cardiacdamagefromchronicuseofchloroquineacasereportandreviewoftheliterature AT benvenutiluizalberto cardiacdamagefromchronicuseofchloroquineacasereportandreviewoftheliterature AT costaroberto cardiacdamagefromchronicuseofchloroquineacasereportandreviewoftheliterature AT pedrosaanisioa cardiacdamagefromchronicuseofchloroquineacasereportandreviewoftheliterature AT nishiokasilvanaad cardiacdamagefromchronicuseofchloroquineacasereportandreviewoftheliterature |
| _version_ |
1756381463784194048 |