Prevalence of antinuclear autoantibodies in the serum of normal blood dornors
OBJECTIVE:To examine the presence of serum antinuclear autoantibodies in a healthy population. METHODS: Serum of 500 normal blood donors between 18 and 60 years of age were tested for the presence of autoantibodies. Antinuclear antibodies were detected by indirect immunofluorescence technique using HEp-2 epithelial cells as the substrate. The presence of dnaN was detected by indirect immunofluorescence technique using Critidia lucillae as the substrate. Anti-SSA (RO), anti-SSB (LA), anti-Sm, and anti-RNP were determined by double radial immunodiffusion. RESULTS: In the evaluation of the presence of serum antibodies, antinuclear antibodies were detected in 22.6% of the sera. The presence of other antibodies was not significant. The majority of the titers were 1:40. CONCLUSION: The presence of autoantibodies is not necessarily pathologic and has to be related to the age group, gender, and clinical condition of the patient.
Main Authors: | Fernandez,Solange Assuncion Villagra, Lobo,Alice Zoghbi Coelho, Oliveira,Zilda Najjar Prado de, Fukumori,Ligia Maria Ichimura, Périgo,Alexandre Marques, Rivitti,Evandro A. |
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Format: | Digital revista |
Language: | English |
Published: |
Faculdade de Medicina / Universidade de São Paulo - FM/USP
2003
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Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812003000600005 |
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