A potent inflammatory response is triggered in asymptomatic blood donors with recent SARS-CoV-2 infection

ABSTRACT Background: The inflammatory response plays a significant role in the outcome of coronavirus disease (COVID-19). Methods: We investigated plasma cytokine and chemokine concentrations in non-infected (NI), asymptomatic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-infected blood donors (AS), and patients with severe COVID-19 (SC). Results: The SC group showed significantly higher levels of interleukin 6 (IL-6), IL-10, and CCL5 than the AS and NI groups. The SC and AS groups had considerably greater CXCL9 and CXCL10 concentrations than the NI group. Only NI and infected people showed separate clusters in the principal component analysis. Conclusions: SC, as well as AS was characterized by an inflammatory profile.

Bibliographic Details

Main Authors:	Martins,Marina Lobato, Silva-Malta,Maria Clara Fernandes da, Araújo,Argus Leão, Gonçalves,Fabíola Araújo, Botelho,Maiara de Lourdes, Oliveira,Isabelle Rocha de, Boy,Luciana de Souza Madeira Ferreira, Moreira,Hélinse Medeiros, Barbosa-Stancioli,Edel Figueiredo, Ribeiro,Maísa Aparecida, Chaves,Daniel Gonçalves
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Medicina Tropical - SBMT 2022
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822022000100626
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