Emergence of aph(3’)-VI and accumulation of aminoglycoside modifying enzyme genes in KPC-2-possessing Enterobacter aerogenes isolates from infections and colonization in patients from Recife-PE, Brazil
Abstract INTRODUCTION: The objective of this study was to characterize genes of aminoglycoside modifying enzymes (AMEs) in colonizing and infecting isolates of E. aerogenes harboring bla KPC from patients at a public hospital in Recife-PE, Brazil. METHODS: We analyzed 29 E. aerogenes clinical isolates resistant to aminoglycosides. AMEs genes were investigated by PCR and sequencing. RESULTS: Colonizing and infecting isolates mainly presented the genetic profiles aac(3)-IIa/aph(3’)-VI or ant(2”)-IIa/aph(3’)-VI. This is the first report of aph(3’)-VI in E. aerogenes harboring bla KPC in Brazil. CONCLUSIONS: The results highlight the importance in establishing rigorous methods for the surveillance of resistance genes, especially in colonized patients.
Main Authors: | Firmo,Elza Ferreira, Cabral,Adriane Borges, Oliveira,Érica Maria de, Lopes,Ana Catarina Souza |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira de Medicina Tropical - SBMT
2019
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100669 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
KPC-producing Enterobacter aerogenes infection
by: Tuon,Felipe F., et al.
Published: (2015) -
Detection of virulence and β-lactamase encoding genes in Enterobacter aerogenes and Enterobacter cloacae clinical isolates from Brazil
by: Azevedo,Paola Aparecida Alves, et al.
Published: (2018) -
The prevalence of aminoglycoside-modifying enzyme genes (aac (6')-I, aac (6')-II, ant (2")-I, aph (3')-VI) in Pseudomonas aeruginosa
by: Vaziri,Farzam, et al.
Published: (2011) -
KPC and VIM producing Enterobacter cloacae strain from a Hospital in Northeastern Venezuela
by: Martínez,Dianny, et al.
Published: (2015) -
Identification of plasmid IncQ1 and NTEKPC-IId harboring bla KPC-2 in isolates from Klebsiella pneumoniae infections in patients from Recife-PE, Brazil
by: Lima,Giselle Jucá de, et al.
Published: (2020)