Effect of artemisinin-piperaquine treatment on the electrocardiogram of malaria patients
Abstract INTRODUCTION: Concern regarding the cardiotoxicity of antimalarials has been renewed because of their potential to cause QT/QTc interval prolongation related to torsade de pointes (TdP). Artemisinin-piperaquine (AP) is considered an effective artemisinin-based combination therapy (ACT) for malaria. METHODS: This study involved a retrospective analysis of clinical data of 93 hospitalized malaria patients who had received AP orally. Electrocardiograms (ECGs) were obtained at specific time points in the original study. RESULTS: Some cases of QT prolongation were observed. However, no TdP was found. CONCLUSIONS: AP may cause QT interval prolongation in some malaria patients but may not lead to TdP.
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Main Authors: | Wu,Wanting, Liang,Yuan, Wu,Guangchao, Su,Yinghang, Zhang,Hongying, Zhang,Zhenyan, Deng,Changsheng, Wang,Qi, Huang,Bo, Tan,Bo, Zhou,Chongjun, Song,Jianping |
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Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira de Medicina Tropical - SBMT
2019
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Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100656 |
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