Seroepidemiology of Trypanosoma cruzi infection in the semiarid rural zone of the State of Rio Grande do Norte, Brazil

Seroepidemiology of Trypanosoma cruzi infection in the semiarid rural zone of the State of Rio Grande do Norte, Brazil

INTRODUCTION: A seroepidemiological survey was carried out to evaluate Trypanosoma cruzi infection in an endemic area of the State of Rio Grande do Norte, Brazil, involving rural residents. METHODS: Sixteen municipalities were randomly selected, 15 from the west mesoregion and one from the central, with an estimated population of 83,852 individuals. A total of 1,950 blood samples were collected in the west mesoregion and 390 in Caicó. Anti-T. cruzi antibodies were detected using the Chagatest® ELISA HAI-hemagglutination kits and indirect immunofluorescence. As sera presented indeterminate results, TESAcruzi® western blot was performed to confirm reactivity. RESULTS: An estimated seroprevalence of 6.5% was determined for the west mesoregion and 3.3% for Caicó. Seropositivity rises progressively with the age of individuals, up to 40 years in Caicó and up to 50 years in the west mesoregion. Only educational level and knowledge regarding the triatomine were associated with seropositivity. No seroreactive individuals under 18 years of age were identified. CONCLUSIONS: Infection by T. cruzi remains high and is concentrated in municipalities in the central western area of the west mesoregion; however, evidence suggests a decline in vector transmission in this mesoregion and in Caicó. Epidemiological variables appear not to influence seropositivity, with the exception of education and knowledge concerning the triatomine, among seroreactive individuals from the west mesoregion.

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Main Authors: Brito,Carlos Ramon do Nascimento, Sampaio,George Harisson Felinto, Câmara,Antonia Cláudia Jácome da, Nunes,Daniela Ferreira, Azevedo,Paulo Roberto Medeiros de, Chiari,Egler, Galvão,Lúcia Maria da Cunha
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Medicina Tropical - SBMT 2012
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000300013
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spelling oai:scielo:S0037-868220120003000132021-04-07Seroepidemiology of Trypanosoma cruzi infection in the semiarid rural zone of the State of Rio Grande do Norte, BrazilBrito,Carlos Ramon do NascimentoSampaio,George Harisson FelintoCâmara,Antonia Cláudia Jácome daNunes,Daniela FerreiraAzevedo,Paulo Roberto Medeiros deChiari,EglerGalvão,Lúcia Maria da Cunha Trypanosoma cruzi Chagas disease Seroprevalence Epidemiological variables INTRODUCTION: A seroepidemiological survey was carried out to evaluate Trypanosoma cruzi infection in an endemic area of the State of Rio Grande do Norte, Brazil, involving rural residents. METHODS: Sixteen municipalities were randomly selected, 15 from the west mesoregion and one from the central, with an estimated population of 83,852 individuals. A total of 1,950 blood samples were collected in the west mesoregion and 390 in Caicó. Anti-T. cruzi antibodies were detected using the Chagatest® ELISA HAI-hemagglutination kits and indirect immunofluorescence. As sera presented indeterminate results, TESAcruzi® western blot was performed to confirm reactivity. RESULTS: An estimated seroprevalence of 6.5% was determined for the west mesoregion and 3.3% for Caicó. Seropositivity rises progressively with the age of individuals, up to 40 years in Caicó and up to 50 years in the west mesoregion. Only educational level and knowledge regarding the triatomine were associated with seropositivity. No seroreactive individuals under 18 years of age were identified. CONCLUSIONS: Infection by T. cruzi remains high and is concentrated in municipalities in the central western area of the west mesoregion; however, evidence suggests a decline in vector transmission in this mesoregion and in Caicó. Epidemiological variables appear not to influence seropositivity, with the exception of education and knowledge concerning the triatomine, among seroreactive individuals from the west mesoregion.info:eu-repo/semantics/openAccessSociedade Brasileira de Medicina Tropical - SBMTRevista da Sociedade Brasileira de Medicina Tropical v.45 n.3 20122012-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000300013en10.1590/S0037-86822012000300013
institution SCIELO
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country Brasil
countrycode BR
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libraryname SciELO
language English
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author Brito,Carlos Ramon do Nascimento
Sampaio,George Harisson Felinto
Câmara,Antonia Cláudia Jácome da
Nunes,Daniela Ferreira
Azevedo,Paulo Roberto Medeiros de
Chiari,Egler
Galvão,Lúcia Maria da Cunha
spellingShingle Brito,Carlos Ramon do Nascimento
Sampaio,George Harisson Felinto
Câmara,Antonia Cláudia Jácome da
Nunes,Daniela Ferreira
Azevedo,Paulo Roberto Medeiros de
Chiari,Egler
Galvão,Lúcia Maria da Cunha
Seroepidemiology of Trypanosoma cruzi infection in the semiarid rural zone of the State of Rio Grande do Norte, Brazil
author_facet Brito,Carlos Ramon do Nascimento
Sampaio,George Harisson Felinto
Câmara,Antonia Cláudia Jácome da
Nunes,Daniela Ferreira
Azevedo,Paulo Roberto Medeiros de
Chiari,Egler
Galvão,Lúcia Maria da Cunha
author_sort Brito,Carlos Ramon do Nascimento
title Seroepidemiology of Trypanosoma cruzi infection in the semiarid rural zone of the State of Rio Grande do Norte, Brazil
title_short Seroepidemiology of Trypanosoma cruzi infection in the semiarid rural zone of the State of Rio Grande do Norte, Brazil
title_full Seroepidemiology of Trypanosoma cruzi infection in the semiarid rural zone of the State of Rio Grande do Norte, Brazil
title_fullStr Seroepidemiology of Trypanosoma cruzi infection in the semiarid rural zone of the State of Rio Grande do Norte, Brazil
title_full_unstemmed Seroepidemiology of Trypanosoma cruzi infection in the semiarid rural zone of the State of Rio Grande do Norte, Brazil
title_sort seroepidemiology of trypanosoma cruzi infection in the semiarid rural zone of the state of rio grande do norte, brazil
description INTRODUCTION: A seroepidemiological survey was carried out to evaluate Trypanosoma cruzi infection in an endemic area of the State of Rio Grande do Norte, Brazil, involving rural residents. METHODS: Sixteen municipalities were randomly selected, 15 from the west mesoregion and one from the central, with an estimated population of 83,852 individuals. A total of 1,950 blood samples were collected in the west mesoregion and 390 in Caicó. Anti-T. cruzi antibodies were detected using the Chagatest® ELISA HAI-hemagglutination kits and indirect immunofluorescence. As sera presented indeterminate results, TESAcruzi® western blot was performed to confirm reactivity. RESULTS: An estimated seroprevalence of 6.5% was determined for the west mesoregion and 3.3% for Caicó. Seropositivity rises progressively with the age of individuals, up to 40 years in Caicó and up to 50 years in the west mesoregion. Only educational level and knowledge regarding the triatomine were associated with seropositivity. No seroreactive individuals under 18 years of age were identified. CONCLUSIONS: Infection by T. cruzi remains high and is concentrated in municipalities in the central western area of the west mesoregion; however, evidence suggests a decline in vector transmission in this mesoregion and in Caicó. Epidemiological variables appear not to influence seropositivity, with the exception of education and knowledge concerning the triatomine, among seroreactive individuals from the west mesoregion.
publisher Sociedade Brasileira de Medicina Tropical - SBMT
publishDate 2012
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000300013
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