Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV
HIV coinfection modifies the clinical course of leishmaniasis by promoting a Th2 pattern of cytokine production. However, little information is available regarding the lymphocytic response in untreated coinfected patients. This work presents the immunophenotyping of Leishmania-stimulated T cells from a treatment-naÏve HIV+ patient with ML. Leishmania braziliensis antigens induced CD69 expression on CD3+CD4+ and CD3+CD8+ cells. It also increased IL-4 intracellular staining on CD3+CD4+GATA3- population and decreased the percentage of CD3+CD4+IL-17+ cells. This suggests that modulations in the IL-4R/STAT6 pathway and the Th17 population may serve as parasitic evasion mechanisms in HIV/ML. Further studies are required to confirm these results.
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Sociedade Brasileira de Medicina Tropical - SBMT
2011
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| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000400025 |
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oai:scielo:S0037-868220110004000252016-09-30Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIVCastellano,Lúcio RobertoLlaguno,MauricioSilva,Marcos ViníciusMachado,Juliana ReisCorreia,DalmoSilva-Vergara,Mario LeónRodrigues,Virmondes Mucosal leishmaniasis Leishmania braziliensis HIV coinfection HIV coinfection modifies the clinical course of leishmaniasis by promoting a Th2 pattern of cytokine production. However, little information is available regarding the lymphocytic response in untreated coinfected patients. This work presents the immunophenotyping of Leishmania-stimulated T cells from a treatment-naÏve HIV+ patient with ML. Leishmania braziliensis antigens induced CD69 expression on CD3+CD4+ and CD3+CD8+ cells. It also increased IL-4 intracellular staining on CD3+CD4+GATA3- population and decreased the percentage of CD3+CD4+IL-17+ cells. This suggests that modulations in the IL-4R/STAT6 pathway and the Th17 population may serve as parasitic evasion mechanisms in HIV/ML. Further studies are required to confirm these results.info:eu-repo/semantics/openAccessSociedade Brasileira de Medicina Tropical - SBMTRevista da Sociedade Brasileira de Medicina Tropical v.44 n.4 20112011-08-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000400025en10.1590/S0037-86822011000400025 |
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Castellano,Lúcio Roberto Llaguno,Mauricio Silva,Marcos Vinícius Machado,Juliana Reis Correia,Dalmo Silva-Vergara,Mario León Rodrigues,Virmondes |
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Castellano,Lúcio Roberto Llaguno,Mauricio Silva,Marcos Vinícius Machado,Juliana Reis Correia,Dalmo Silva-Vergara,Mario León Rodrigues,Virmondes Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV |
| author_facet |
Castellano,Lúcio Roberto Llaguno,Mauricio Silva,Marcos Vinícius Machado,Juliana Reis Correia,Dalmo Silva-Vergara,Mario León Rodrigues,Virmondes |
| author_sort |
Castellano,Lúcio Roberto |
| title |
Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV |
| title_short |
Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV |
| title_full |
Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV |
| title_fullStr |
Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV |
| title_full_unstemmed |
Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV |
| title_sort |
immunophenotyping of circulating t cells in a mucosal leishmaniasis patient coinfected with hiv |
| description |
HIV coinfection modifies the clinical course of leishmaniasis by promoting a Th2 pattern of cytokine production. However, little information is available regarding the lymphocytic response in untreated coinfected patients. This work presents the immunophenotyping of Leishmania-stimulated T cells from a treatment-naÏve HIV+ patient with ML. Leishmania braziliensis antigens induced CD69 expression on CD3+CD4+ and CD3+CD8+ cells. It also increased IL-4 intracellular staining on CD3+CD4+GATA3- population and decreased the percentage of CD3+CD4+IL-17+ cells. This suggests that modulations in the IL-4R/STAT6 pathway and the Th17 population may serve as parasitic evasion mechanisms in HIV/ML. Further studies are required to confirm these results. |
| publisher |
Sociedade Brasileira de Medicina Tropical - SBMT |
| publishDate |
2011 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000400025 |
| work_keys_str_mv |
AT castellanolucioroberto immunophenotypingofcirculatingtcellsinamucosalleishmaniasispatientcoinfectedwithhiv AT llagunomauricio immunophenotypingofcirculatingtcellsinamucosalleishmaniasispatientcoinfectedwithhiv AT silvamarcosvinicius immunophenotypingofcirculatingtcellsinamucosalleishmaniasispatientcoinfectedwithhiv AT machadojulianareis immunophenotypingofcirculatingtcellsinamucosalleishmaniasispatientcoinfectedwithhiv AT correiadalmo immunophenotypingofcirculatingtcellsinamucosalleishmaniasispatientcoinfectedwithhiv AT silvavergaramarioleon immunophenotypingofcirculatingtcellsinamucosalleishmaniasispatientcoinfectedwithhiv AT rodriguesvirmondes immunophenotypingofcirculatingtcellsinamucosalleishmaniasispatientcoinfectedwithhiv |
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