Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice

Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice

High molecular weight components from Ascaris suum extract suppress ovalbumin-specific immunity in mice. In IFN-γ-deficient mice, ovalbumin-specific delayed-type hypersensitivity reactions are more strongly downregulated by these suppressive components. Here, the cellularity of the delayed-type hypersensitivity reaction in IFN-γ-deficient mice and the increased downregulation induced by Ascaris suum components were analyzed. IL-12p40-dependent neutrophilic influx was predominant. Suboptimal doses of the suppressive fraction from this nematode completely inhibited the hypersensitivity reaction, thus indicating intensification of the immunosuppression under conditions of intense recruitment of IFN-γ-independent neutrophils.

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Main Authors: Souza,Valdênia Maria Oliveira, Macedo,Mahasti Sahihi
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Medicina Tropical - SBMT 2009
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822009000300021
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spelling oai:scielo:S0037-868220090003000212009-08-10Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient miceSouza,Valdênia Maria OliveiraMacedo,Mahasti Sahihi Ascaris suum Delayed-type hypersensitivity Immunosuppression IFN-γ-deficient mice Neutrophil High molecular weight components from Ascaris suum extract suppress ovalbumin-specific immunity in mice. In IFN-γ-deficient mice, ovalbumin-specific delayed-type hypersensitivity reactions are more strongly downregulated by these suppressive components. Here, the cellularity of the delayed-type hypersensitivity reaction in IFN-γ-deficient mice and the increased downregulation induced by Ascaris suum components were analyzed. IL-12p40-dependent neutrophilic influx was predominant. Suboptimal doses of the suppressive fraction from this nematode completely inhibited the hypersensitivity reaction, thus indicating intensification of the immunosuppression under conditions of intense recruitment of IFN-γ-independent neutrophils.info:eu-repo/semantics/openAccessSociedade Brasileira de Medicina Tropical - SBMTRevista da Sociedade Brasileira de Medicina Tropical v.42 n.3 20092009-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822009000300021en10.1590/S0037-86822009000300021
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Souza,Valdênia Maria Oliveira
Macedo,Mahasti Sahihi
spellingShingle Souza,Valdênia Maria Oliveira
Macedo,Mahasti Sahihi
Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice
author_facet Souza,Valdênia Maria Oliveira
Macedo,Mahasti Sahihi
author_sort Souza,Valdênia Maria Oliveira
title Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice
title_short Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice
title_full Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice
title_fullStr Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice
title_full_unstemmed Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice
title_sort boosting the suppressive effects of ascaris suum components in ifn-γ-deficient mice
description High molecular weight components from Ascaris suum extract suppress ovalbumin-specific immunity in mice. In IFN-γ-deficient mice, ovalbumin-specific delayed-type hypersensitivity reactions are more strongly downregulated by these suppressive components. Here, the cellularity of the delayed-type hypersensitivity reaction in IFN-γ-deficient mice and the increased downregulation induced by Ascaris suum components were analyzed. IL-12p40-dependent neutrophilic influx was predominant. Suboptimal doses of the suppressive fraction from this nematode completely inhibited the hypersensitivity reaction, thus indicating intensification of the immunosuppression under conditions of intense recruitment of IFN-γ-independent neutrophils.
publisher Sociedade Brasileira de Medicina Tropical - SBMT
publishDate 2009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822009000300021
work_keys_str_mv AT souzavaldeniamariaoliveira boostingthesuppressiveeffectsofascarissuumcomponentsinifngdeficientmice
AT macedomahastisahihi boostingthesuppressiveeffectsofascarissuumcomponentsinifngdeficientmice
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