Chemical composition, toxicity and larvicidal and antifungal activities of Persea americana (avocado) seed extracts
The present study had the aim of testing the hexane and methanol extracts of avocado seeds, in order to determine their toxicity towards Artemia salina, evaluate their larvicidal activity towards Aedes aegypti and investigate their in vitro antifungal potential against strains of Candida spp, Cryptococcus neoformans and Malassezia pachydermatis through the microdilution technique. In toxicity tests on Artemia salina, the hexane and methanol extracts from avocado seeds showed LC50 values of 2.37 and 24.13mg mL-1 respectively. Against Aedes aegypti larvae, the LC50 results obtained were 16.7mg mL-1 for hexane extract and 8.87mg mL-1 for methanol extract from avocado seeds. The extracts tested were also active against all the yeast strains tested in vitro, with differing results such that the minimum inhibitory concentration of the hexane extract ranged from 0.625 to 1.25mg L-¹, from 0.312 to 0.625mg mL-1 and from 0.031 to 0.625mg mL-1, for the strains of Candida spp, Cryptococcus neoformans and Malassezia pachydermatis, respectively. The minimal inhibitory concentration for the methanol extract ranged from 0.125 to 0.625mg mL-1, from 0.08 to 0.156mg mL-1 and from 0.312 to 0.625mg mL-1, for the strains of Candida spp., Cryptococcus neoformans and Malassezia pachydermatis, respectively.
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Sociedade Brasileira de Medicina Tropical - SBMT
2009
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oai:scielo:S0037-868220090002000032009-05-08Chemical composition, toxicity and larvicidal and antifungal activities of Persea americana (avocado) seed extractsLeite,João Jaime GiffoniBrito,Érika Helena SallesCordeiro,Rossana AguiarBrilhante,Raimunda Sâmia NogueiraSidrim,José Júlio CostaBertini,Luciana MedeirosMorais,Selene Maia deRocha,Marcos Fábio Gadelha Avocado seeds Artemia salina Aedes aegypti Yeasts The present study had the aim of testing the hexane and methanol extracts of avocado seeds, in order to determine their toxicity towards Artemia salina, evaluate their larvicidal activity towards Aedes aegypti and investigate their in vitro antifungal potential against strains of Candida spp, Cryptococcus neoformans and Malassezia pachydermatis through the microdilution technique. In toxicity tests on Artemia salina, the hexane and methanol extracts from avocado seeds showed LC50 values of 2.37 and 24.13mg mL-1 respectively. Against Aedes aegypti larvae, the LC50 results obtained were 16.7mg mL-1 for hexane extract and 8.87mg mL-1 for methanol extract from avocado seeds. The extracts tested were also active against all the yeast strains tested in vitro, with differing results such that the minimum inhibitory concentration of the hexane extract ranged from 0.625 to 1.25mg L-¹, from 0.312 to 0.625mg mL-1 and from 0.031 to 0.625mg mL-1, for the strains of Candida spp, Cryptococcus neoformans and Malassezia pachydermatis, respectively. The minimal inhibitory concentration for the methanol extract ranged from 0.125 to 0.625mg mL-1, from 0.08 to 0.156mg mL-1 and from 0.312 to 0.625mg mL-1, for the strains of Candida spp., Cryptococcus neoformans and Malassezia pachydermatis, respectively.info:eu-repo/semantics/openAccessSociedade Brasileira de Medicina Tropical - SBMTRevista da Sociedade Brasileira de Medicina Tropical v.42 n.2 20092009-04-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822009000200003en10.1590/S0037-86822009000200003 |
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Leite,João Jaime Giffoni Brito,Érika Helena Salles Cordeiro,Rossana Aguiar Brilhante,Raimunda Sâmia Nogueira Sidrim,José Júlio Costa Bertini,Luciana Medeiros Morais,Selene Maia de Rocha,Marcos Fábio Gadelha |
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Leite,João Jaime Giffoni Brito,Érika Helena Salles Cordeiro,Rossana Aguiar Brilhante,Raimunda Sâmia Nogueira Sidrim,José Júlio Costa Bertini,Luciana Medeiros Morais,Selene Maia de Rocha,Marcos Fábio Gadelha Chemical composition, toxicity and larvicidal and antifungal activities of Persea americana (avocado) seed extracts |
author_facet |
Leite,João Jaime Giffoni Brito,Érika Helena Salles Cordeiro,Rossana Aguiar Brilhante,Raimunda Sâmia Nogueira Sidrim,José Júlio Costa Bertini,Luciana Medeiros Morais,Selene Maia de Rocha,Marcos Fábio Gadelha |
author_sort |
Leite,João Jaime Giffoni |
title |
Chemical composition, toxicity and larvicidal and antifungal activities of Persea americana (avocado) seed extracts |
title_short |
Chemical composition, toxicity and larvicidal and antifungal activities of Persea americana (avocado) seed extracts |
title_full |
Chemical composition, toxicity and larvicidal and antifungal activities of Persea americana (avocado) seed extracts |
title_fullStr |
Chemical composition, toxicity and larvicidal and antifungal activities of Persea americana (avocado) seed extracts |
title_full_unstemmed |
Chemical composition, toxicity and larvicidal and antifungal activities of Persea americana (avocado) seed extracts |
title_sort |
chemical composition, toxicity and larvicidal and antifungal activities of persea americana (avocado) seed extracts |
description |
The present study had the aim of testing the hexane and methanol extracts of avocado seeds, in order to determine their toxicity towards Artemia salina, evaluate their larvicidal activity towards Aedes aegypti and investigate their in vitro antifungal potential against strains of Candida spp, Cryptococcus neoformans and Malassezia pachydermatis through the microdilution technique. In toxicity tests on Artemia salina, the hexane and methanol extracts from avocado seeds showed LC50 values of 2.37 and 24.13mg mL-1 respectively. Against Aedes aegypti larvae, the LC50 results obtained were 16.7mg mL-1 for hexane extract and 8.87mg mL-1 for methanol extract from avocado seeds. The extracts tested were also active against all the yeast strains tested in vitro, with differing results such that the minimum inhibitory concentration of the hexane extract ranged from 0.625 to 1.25mg L-¹, from 0.312 to 0.625mg mL-1 and from 0.031 to 0.625mg mL-1, for the strains of Candida spp, Cryptococcus neoformans and Malassezia pachydermatis, respectively. The minimal inhibitory concentration for the methanol extract ranged from 0.125 to 0.625mg mL-1, from 0.08 to 0.156mg mL-1 and from 0.312 to 0.625mg mL-1, for the strains of Candida spp., Cryptococcus neoformans and Malassezia pachydermatis, respectively. |
publisher |
Sociedade Brasileira de Medicina Tropical - SBMT |
publishDate |
2009 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822009000200003 |
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