Prevalence of hepatitis C virus infection and HCV genotypes among hemophiliacs in the State of Bahia, Northeastern Brazil: analysis of serological and virological parameters
The objective of the present study was to analyze HCV serological and virological parameters from hemophiliacs in the State of Bahia. Anti-HCV was investigated by ELISA in a cohort of 268 hemophiliacs A/B who were followed-up in a reference unit for hemotherapy in the State of Bahia. HCV viremia and genotypes were also determined from a subset of 66 anti-HCV seropositive hemophiliacs. Seroprevalence among hemophiliacs was 42.2% (95% CI 36.5-48.1) and was significantly higher (p<0.05) according to age >10 years, presence of factor VIII/IX inhibitory antibodies and other infection markers. None of the hemophiliacs less than 5 years of age were anti-HCV seropositive. Viremia was detectable in 77.3% (51/66). HCV genotype 1 (74%) was the most prevalent followed by genotype 3 (22%) and genotype 2 (4%). Our results indicate that HCV prevalence is still high among hemophiliacs, although HCV transmission was not observed in young hemophiliacs.
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Sociedade Brasileira de Medicina Tropical - SBMT
2005
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oai:scielo:S0037-868220050006000102006-01-04Prevalence of hepatitis C virus infection and HCV genotypes among hemophiliacs in the State of Bahia, Northeastern Brazil: analysis of serological and virological parametersSilva,Luciano KalabricSilva,Maria Betânia Souza daLopes,Gisele BarretoRodart,Itatiana FerreiraCosta,Fernando QuadrosSantana,Nelma P.Paraná,RaymundoSantana,AurelinoReis,Mitermayer Galvão dos Hepatitis C virus Hemophilia Prevalence Genotype Bahia The objective of the present study was to analyze HCV serological and virological parameters from hemophiliacs in the State of Bahia. Anti-HCV was investigated by ELISA in a cohort of 268 hemophiliacs A/B who were followed-up in a reference unit for hemotherapy in the State of Bahia. HCV viremia and genotypes were also determined from a subset of 66 anti-HCV seropositive hemophiliacs. Seroprevalence among hemophiliacs was 42.2% (95% CI 36.5-48.1) and was significantly higher (p<0.05) according to age >10 years, presence of factor VIII/IX inhibitory antibodies and other infection markers. None of the hemophiliacs less than 5 years of age were anti-HCV seropositive. Viremia was detectable in 77.3% (51/66). HCV genotype 1 (74%) was the most prevalent followed by genotype 3 (22%) and genotype 2 (4%). Our results indicate that HCV prevalence is still high among hemophiliacs, although HCV transmission was not observed in young hemophiliacs.info:eu-repo/semantics/openAccessSociedade Brasileira de Medicina Tropical - SBMTRevista da Sociedade Brasileira de Medicina Tropical v.38 n.6 20052005-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822005000600010en10.1590/S0037-86822005000600010 |
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Silva,Luciano Kalabric Silva,Maria Betânia Souza da Lopes,Gisele Barreto Rodart,Itatiana Ferreira Costa,Fernando Quadros Santana,Nelma P. Paraná,Raymundo Santana,Aurelino Reis,Mitermayer Galvão dos |
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Silva,Luciano Kalabric Silva,Maria Betânia Souza da Lopes,Gisele Barreto Rodart,Itatiana Ferreira Costa,Fernando Quadros Santana,Nelma P. Paraná,Raymundo Santana,Aurelino Reis,Mitermayer Galvão dos Prevalence of hepatitis C virus infection and HCV genotypes among hemophiliacs in the State of Bahia, Northeastern Brazil: analysis of serological and virological parameters |
author_facet |
Silva,Luciano Kalabric Silva,Maria Betânia Souza da Lopes,Gisele Barreto Rodart,Itatiana Ferreira Costa,Fernando Quadros Santana,Nelma P. Paraná,Raymundo Santana,Aurelino Reis,Mitermayer Galvão dos |
author_sort |
Silva,Luciano Kalabric |
title |
Prevalence of hepatitis C virus infection and HCV genotypes among hemophiliacs in the State of Bahia, Northeastern Brazil: analysis of serological and virological parameters |
title_short |
Prevalence of hepatitis C virus infection and HCV genotypes among hemophiliacs in the State of Bahia, Northeastern Brazil: analysis of serological and virological parameters |
title_full |
Prevalence of hepatitis C virus infection and HCV genotypes among hemophiliacs in the State of Bahia, Northeastern Brazil: analysis of serological and virological parameters |
title_fullStr |
Prevalence of hepatitis C virus infection and HCV genotypes among hemophiliacs in the State of Bahia, Northeastern Brazil: analysis of serological and virological parameters |
title_full_unstemmed |
Prevalence of hepatitis C virus infection and HCV genotypes among hemophiliacs in the State of Bahia, Northeastern Brazil: analysis of serological and virological parameters |
title_sort |
prevalence of hepatitis c virus infection and hcv genotypes among hemophiliacs in the state of bahia, northeastern brazil: analysis of serological and virological parameters |
description |
The objective of the present study was to analyze HCV serological and virological parameters from hemophiliacs in the State of Bahia. Anti-HCV was investigated by ELISA in a cohort of 268 hemophiliacs A/B who were followed-up in a reference unit for hemotherapy in the State of Bahia. HCV viremia and genotypes were also determined from a subset of 66 anti-HCV seropositive hemophiliacs. Seroprevalence among hemophiliacs was 42.2% (95% CI 36.5-48.1) and was significantly higher (p<0.05) according to age >10 years, presence of factor VIII/IX inhibitory antibodies and other infection markers. None of the hemophiliacs less than 5 years of age were anti-HCV seropositive. Viremia was detectable in 77.3% (51/66). HCV genotype 1 (74%) was the most prevalent followed by genotype 3 (22%) and genotype 2 (4%). Our results indicate that HCV prevalence is still high among hemophiliacs, although HCV transmission was not observed in young hemophiliacs. |
publisher |
Sociedade Brasileira de Medicina Tropical - SBMT |
publishDate |
2005 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822005000600010 |
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