SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study

ABSTRACT This prospective cohort study aims to analyze the surveillance of COVID-19 at a single hematopoietic stem cell transplantation (HSCT) center in Brazil, in 29 patients undergoing allogeneic HSCT and 57 healthcare workers (nurses and dentists), through viral shedding of SARS-CoV-2 in saliva and plasma and seroprevalence of anti-SARS-CoV-2 IgG. In addition, we report two cases with prolonged persistent detection of SARS-CoV-2 without seroconversion. The sample collection was performed seven times for patients and five times for healthcare workers. Only two patients tested positive for SARS-CoV-2 in their saliva and plasma samples (6.9%) without seroconversion. All healthcare workers were asymptomatic and none tested positive. Two patients (6.9%) and four nurses (8%) had positive serology. No dentists had positive viral detection or positive serology. Our results reflect a low prevalence of positive RT-PCR and seroprevalence of SARS-CoV-2 in patients and healthcare workers at a single HSCT center. Results have also corroborated how the rigorous protocols adopted in transplant centers were even more strengthened in this pandemic scenario.

Bibliographic Details

Main Authors:	Mobile,Rafael Zancan, Warnawin,Stephanie von Stein Cubas, Kojo,Teresinha Keiko, Rodrigues,Jéssica Alline Pereira, Cavilha,Adriana Mendes de Quadros, Zerbinati,Rodrigo Melim, Adamoski,Douglas, Oliveira,Jaqueline Carvalho de, Conzentino,Marcelo Santos, Huergo,Luciano Fernandes, Gradia,Daniela Fiori, Braz-Silva,Paulo Henrique, Schussel,Juliana Lucena
Format:	Digital revista
Language:	English
Published:	Instituto de Medicina Tropical de São Paulo 2022
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652022000100221
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