Morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-HAART (Highly Active Antiretroviral Therapy)

Morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-HAART (Highly Active Antiretroviral Therapy)

ABSTRACT Involvement of the digestive system in AIDS pathologies or injuries is frequent. Aiming at comparing the frequency, the importance that these lesions have for death and the survival time in patients using or not using HAART, we studied 322 necropsies classified as follows: Group A - without antiretroviral drugs (185 cases); B - one or two antiretroviral drugs or HAART for less than six months (83 cases); C - HAART for six months or longer (54 cases). In the overall analysis of the digestive system, changes were present in 73.6% of cases. The most frequent was Candida infection (22.7%), followed by cytomegalovirus (19.2%), Histoplasma capsulatum (6.5%), mycobacteria (5.6%), and Toxoplasma gondii (4.3%). T. gondii infection was more frequent in group A compared with group C, and cytomegalovirus (CMV) was more frequent in group A compared with groups B and C (p < 0.05); 2.2% of the deaths were due to gastrointestinal bleeding. Regarding the segments, only in the large intestine, and only cytomegalovirus, were more frequent in group A compared with group C. We conclude that digestive system infections are still frequent, even with the use of HAART. However, the average survival time in group C was more than three times greater than the one in group A and nearly double that of group B, demonstrating the clear benefit of this therapy.

Saved in:
Bibliographic Details
Main Authors: Guimarães,Lucinda Calheiros, Silva,Ana Cristina Araújo Lemos da, Micheletti,Adilha Misson Rua, Moura,Everton Nunes Melo, Silva-Vergara,Mario Léon, Tostes Júnior,Sebastião, Adad,Sheila Jorge
Format: Digital revista
Language:English
Published: Instituto de Medicina Tropical de São Paulo 2017
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652017005000201
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:scielo:S0036-46652017005000201
record_format ojs
spelling oai:scielo:S0036-466520170050002012017-04-07Morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-HAART (Highly Active Antiretroviral Therapy)Guimarães,Lucinda CalheirosSilva,Ana Cristina Araújo Lemos daMicheletti,Adilha Misson RuaMoura,Everton Nunes MeloSilva-Vergara,Mario LéonTostes Júnior,SebastiãoAdad,Sheila Jorge Autopsy Necropsy AIDS Digestive system HAART ABSTRACT Involvement of the digestive system in AIDS pathologies or injuries is frequent. Aiming at comparing the frequency, the importance that these lesions have for death and the survival time in patients using or not using HAART, we studied 322 necropsies classified as follows: Group A - without antiretroviral drugs (185 cases); B - one or two antiretroviral drugs or HAART for less than six months (83 cases); C - HAART for six months or longer (54 cases). In the overall analysis of the digestive system, changes were present in 73.6% of cases. The most frequent was Candida infection (22.7%), followed by cytomegalovirus (19.2%), Histoplasma capsulatum (6.5%), mycobacteria (5.6%), and Toxoplasma gondii (4.3%). T. gondii infection was more frequent in group A compared with group C, and cytomegalovirus (CMV) was more frequent in group A compared with groups B and C (p < 0.05); 2.2% of the deaths were due to gastrointestinal bleeding. Regarding the segments, only in the large intestine, and only cytomegalovirus, were more frequent in group A compared with group C. We conclude that digestive system infections are still frequent, even with the use of HAART. However, the average survival time in group C was more than three times greater than the one in group A and nearly double that of group B, demonstrating the clear benefit of this therapy.info:eu-repo/semantics/openAccessInstituto de Medicina Tropical de São PauloRevista do Instituto de Medicina Tropical de São Paulo v.59 20172017-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652017005000201en10.1590/s1678-9946201759003
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Guimarães,Lucinda Calheiros
Silva,Ana Cristina Araújo Lemos da
Micheletti,Adilha Misson Rua
Moura,Everton Nunes Melo
Silva-Vergara,Mario Léon
Tostes Júnior,Sebastião
Adad,Sheila Jorge
spellingShingle Guimarães,Lucinda Calheiros
Silva,Ana Cristina Araújo Lemos da
Micheletti,Adilha Misson Rua
Moura,Everton Nunes Melo
Silva-Vergara,Mario Léon
Tostes Júnior,Sebastião
Adad,Sheila Jorge
Morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-HAART (Highly Active Antiretroviral Therapy)
author_facet Guimarães,Lucinda Calheiros
Silva,Ana Cristina Araújo Lemos da
Micheletti,Adilha Misson Rua
Moura,Everton Nunes Melo
Silva-Vergara,Mario Léon
Tostes Júnior,Sebastião
Adad,Sheila Jorge
author_sort Guimarães,Lucinda Calheiros
title Morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-HAART (Highly Active Antiretroviral Therapy)
title_short Morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-HAART (Highly Active Antiretroviral Therapy)
title_full Morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-HAART (Highly Active Antiretroviral Therapy)
title_fullStr Morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-HAART (Highly Active Antiretroviral Therapy)
title_full_unstemmed Morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-HAART (Highly Active Antiretroviral Therapy)
title_sort morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-haart (highly active antiretroviral therapy)
description ABSTRACT Involvement of the digestive system in AIDS pathologies or injuries is frequent. Aiming at comparing the frequency, the importance that these lesions have for death and the survival time in patients using or not using HAART, we studied 322 necropsies classified as follows: Group A - without antiretroviral drugs (185 cases); B - one or two antiretroviral drugs or HAART for less than six months (83 cases); C - HAART for six months or longer (54 cases). In the overall analysis of the digestive system, changes were present in 73.6% of cases. The most frequent was Candida infection (22.7%), followed by cytomegalovirus (19.2%), Histoplasma capsulatum (6.5%), mycobacteria (5.6%), and Toxoplasma gondii (4.3%). T. gondii infection was more frequent in group A compared with group C, and cytomegalovirus (CMV) was more frequent in group A compared with groups B and C (p < 0.05); 2.2% of the deaths were due to gastrointestinal bleeding. Regarding the segments, only in the large intestine, and only cytomegalovirus, were more frequent in group A compared with group C. We conclude that digestive system infections are still frequent, even with the use of HAART. However, the average survival time in group C was more than three times greater than the one in group A and nearly double that of group B, demonstrating the clear benefit of this therapy.
publisher Instituto de Medicina Tropical de São Paulo
publishDate 2017
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652017005000201
work_keys_str_mv AT guimaraeslucindacalheiros morphologicalchangesinthedigestivesystemof322necropsiesofpatientswithacquiredimmunedeficiencysyndromecomparisonoffindingspreandposthaarthighlyactiveantiretroviraltherapy
AT silvaanacristinaaraujolemosda morphologicalchangesinthedigestivesystemof322necropsiesofpatientswithacquiredimmunedeficiencysyndromecomparisonoffindingspreandposthaarthighlyactiveantiretroviraltherapy
AT michelettiadilhamissonrua morphologicalchangesinthedigestivesystemof322necropsiesofpatientswithacquiredimmunedeficiencysyndromecomparisonoffindingspreandposthaarthighlyactiveantiretroviraltherapy
AT mouraevertonnunesmelo morphologicalchangesinthedigestivesystemof322necropsiesofpatientswithacquiredimmunedeficiencysyndromecomparisonoffindingspreandposthaarthighlyactiveantiretroviraltherapy
AT silvavergaramarioleon morphologicalchangesinthedigestivesystemof322necropsiesofpatientswithacquiredimmunedeficiencysyndromecomparisonoffindingspreandposthaarthighlyactiveantiretroviraltherapy
AT tostesjuniorsebastiao morphologicalchangesinthedigestivesystemof322necropsiesofpatientswithacquiredimmunedeficiencysyndromecomparisonoffindingspreandposthaarthighlyactiveantiretroviraltherapy
AT adadsheilajorge morphologicalchangesinthedigestivesystemof322necropsiesofpatientswithacquiredimmunedeficiencysyndromecomparisonoffindingspreandposthaarthighlyactiveantiretroviraltherapy
_version_ 1756379922068144128

Similar Items