Confirming the presence of HTLV-1 infection and the absence of HTLV-2 in blood donors from Arequipa, Peru
Epidemiological studies conducted in Peru disclosed HTLV-1 to be prevalent in different ethnic groups, and found HTLV-2 in some Amazonian Indians and in men who have sex with men. No data concerning HTLV-1/2 infection in blood donors from Arequipa, a highlands region in southern Peru, is available. We searched for the presence of HTLV-1 and HTLV-2 antibodies in 2,732 serum samples obtained from blood donors from this geographic area. HTLV-1/2-specific antibodies were detected using an enzyme-linked immunosorbent assay (ELISA) and were confirmed by Western blot (WB). Reactive sera had their blood bags discarded from donation, and the demographic characteristics of the donors were analyzed. Thirty-five sera (1.2%) were HTLV seroreactive by ELISA, and 25 were confirmed HTLV-1-positive by WB. One serum disclosed HTLV-positivity, and the remaining nine serum samples showed indeterminate results by WB; three of which had an HTLV-1 indeterminate Gag profile. The median age of HTLV-positive individuals was 34.6 years; 27 were male and eight were female. All individuals were from southern Peru: 27 from Arequipa, five from Puno, and three from Cuzco. HTLV co-positivity with hepatitis B (five sera) and syphilis (one serum) were detected. Previous transfusion and tattooing were observed in two and one individuals, respectively. No serum was positive for HTLV/HIV co-infection. This study confirmed, for the first time, HTLV-1 infection and the absence of HTLV-2 infection in blood donors from Arequipa, Peru and suggests vertical transmission as the major route of HTLV-1 transmission and acquisition in this geographic region.
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Instituto de Medicina Tropical de São Paulo
2009
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oai:scielo:S0036-466520090001000052009-02-12Confirming the presence of HTLV-1 infection and the absence of HTLV-2 in blood donors from Arequipa, PeruQuispe,Nadia Carmela SantosFeria,Edwin BengoaSantos-Fortuna,Elizabeth de losCaterino-de-Araujo,Adele Human T cell lymphotropic virus 1 (HTLV-1) HTLV-2 Serology Blood donors Peru Epidemiological studies conducted in Peru disclosed HTLV-1 to be prevalent in different ethnic groups, and found HTLV-2 in some Amazonian Indians and in men who have sex with men. No data concerning HTLV-1/2 infection in blood donors from Arequipa, a highlands region in southern Peru, is available. We searched for the presence of HTLV-1 and HTLV-2 antibodies in 2,732 serum samples obtained from blood donors from this geographic area. HTLV-1/2-specific antibodies were detected using an enzyme-linked immunosorbent assay (ELISA) and were confirmed by Western blot (WB). Reactive sera had their blood bags discarded from donation, and the demographic characteristics of the donors were analyzed. Thirty-five sera (1.2%) were HTLV seroreactive by ELISA, and 25 were confirmed HTLV-1-positive by WB. One serum disclosed HTLV-positivity, and the remaining nine serum samples showed indeterminate results by WB; three of which had an HTLV-1 indeterminate Gag profile. The median age of HTLV-positive individuals was 34.6 years; 27 were male and eight were female. All individuals were from southern Peru: 27 from Arequipa, five from Puno, and three from Cuzco. HTLV co-positivity with hepatitis B (five sera) and syphilis (one serum) were detected. Previous transfusion and tattooing were observed in two and one individuals, respectively. No serum was positive for HTLV/HIV co-infection. This study confirmed, for the first time, HTLV-1 infection and the absence of HTLV-2 infection in blood donors from Arequipa, Peru and suggests vertical transmission as the major route of HTLV-1 transmission and acquisition in this geographic region.info:eu-repo/semantics/openAccessInstituto de Medicina Tropical de São PauloRevista do Instituto de Medicina Tropical de São Paulo v.51 n.1 20092009-02-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652009000100005en10.1590/S0036-46652009000100005 |
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| author |
Quispe,Nadia Carmela Santos Feria,Edwin Bengoa Santos-Fortuna,Elizabeth de los Caterino-de-Araujo,Adele |
| spellingShingle |
Quispe,Nadia Carmela Santos Feria,Edwin Bengoa Santos-Fortuna,Elizabeth de los Caterino-de-Araujo,Adele Confirming the presence of HTLV-1 infection and the absence of HTLV-2 in blood donors from Arequipa, Peru |
| author_facet |
Quispe,Nadia Carmela Santos Feria,Edwin Bengoa Santos-Fortuna,Elizabeth de los Caterino-de-Araujo,Adele |
| author_sort |
Quispe,Nadia Carmela Santos |
| title |
Confirming the presence of HTLV-1 infection and the absence of HTLV-2 in blood donors from Arequipa, Peru |
| title_short |
Confirming the presence of HTLV-1 infection and the absence of HTLV-2 in blood donors from Arequipa, Peru |
| title_full |
Confirming the presence of HTLV-1 infection and the absence of HTLV-2 in blood donors from Arequipa, Peru |
| title_fullStr |
Confirming the presence of HTLV-1 infection and the absence of HTLV-2 in blood donors from Arequipa, Peru |
| title_full_unstemmed |
Confirming the presence of HTLV-1 infection and the absence of HTLV-2 in blood donors from Arequipa, Peru |
| title_sort |
confirming the presence of htlv-1 infection and the absence of htlv-2 in blood donors from arequipa, peru |
| description |
Epidemiological studies conducted in Peru disclosed HTLV-1 to be prevalent in different ethnic groups, and found HTLV-2 in some Amazonian Indians and in men who have sex with men. No data concerning HTLV-1/2 infection in blood donors from Arequipa, a highlands region in southern Peru, is available. We searched for the presence of HTLV-1 and HTLV-2 antibodies in 2,732 serum samples obtained from blood donors from this geographic area. HTLV-1/2-specific antibodies were detected using an enzyme-linked immunosorbent assay (ELISA) and were confirmed by Western blot (WB). Reactive sera had their blood bags discarded from donation, and the demographic characteristics of the donors were analyzed. Thirty-five sera (1.2%) were HTLV seroreactive by ELISA, and 25 were confirmed HTLV-1-positive by WB. One serum disclosed HTLV-positivity, and the remaining nine serum samples showed indeterminate results by WB; three of which had an HTLV-1 indeterminate Gag profile. The median age of HTLV-positive individuals was 34.6 years; 27 were male and eight were female. All individuals were from southern Peru: 27 from Arequipa, five from Puno, and three from Cuzco. HTLV co-positivity with hepatitis B (five sera) and syphilis (one serum) were detected. Previous transfusion and tattooing were observed in two and one individuals, respectively. No serum was positive for HTLV/HIV co-infection. This study confirmed, for the first time, HTLV-1 infection and the absence of HTLV-2 infection in blood donors from Arequipa, Peru and suggests vertical transmission as the major route of HTLV-1 transmission and acquisition in this geographic region. |
| publisher |
Instituto de Medicina Tropical de São Paulo |
| publishDate |
2009 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652009000100005 |
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