Histopathology of cutaneous and mucosal lesions in human paracoccidioidomycosis
Biopsies from cutaneous and mucosal lesions from 40 patients with active paracoccidioidomycosis, were studied histopathologically. All cases exhibited chronic granulomatous inflammation and 38 also presented suppuration; this picture corresponded to the mixed mycotic granuloma (MMG). Pseudoepitheliomatous hyperplasia and the transepidermic (or epithelial) elimination of the parasite, were observed in all cases. In paracoccidioidomycosis elimination takes place through formation of progressive edema, accompained by exocytosis. The edema gives rise to spongiosis, microvesicles and microabscesses which not only contain the fungus but also, various cellular elements. Cells in charge of the phagocytic process were essentialy Langhans giant cells; PMN's, epithelioid and foreign body giant cells were poor phagocytes. An additional finding was the presence of fibrosis in most biopsies.
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Instituto de Medicina Tropical de São Paulo
1987
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oai:scielo:S0036-466519870002000052011-02-17Histopathology of cutaneous and mucosal lesions in human paracoccidioidomycosisUribe,FabioZuluaga,Angela I.León,WalterRestrepo,Angela Paracoccidioidomycosis Histopathology Mixed mycotic granuloma Transepithelial elimination of parasites Biopsies from cutaneous and mucosal lesions from 40 patients with active paracoccidioidomycosis, were studied histopathologically. All cases exhibited chronic granulomatous inflammation and 38 also presented suppuration; this picture corresponded to the mixed mycotic granuloma (MMG). Pseudoepitheliomatous hyperplasia and the transepidermic (or epithelial) elimination of the parasite, were observed in all cases. In paracoccidioidomycosis elimination takes place through formation of progressive edema, accompained by exocytosis. The edema gives rise to spongiosis, microvesicles and microabscesses which not only contain the fungus but also, various cellular elements. Cells in charge of the phagocytic process were essentialy Langhans giant cells; PMN's, epithelioid and foreign body giant cells were poor phagocytes. An additional finding was the presence of fibrosis in most biopsies.info:eu-repo/semantics/openAccessInstituto de Medicina Tropical de São PauloRevista do Instituto de Medicina Tropical de São Paulo v.29 n.2 19871987-04-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651987000200005en10.1590/S0036-46651987000200005 |
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Uribe,Fabio Zuluaga,Angela I. León,Walter Restrepo,Angela |
| spellingShingle |
Uribe,Fabio Zuluaga,Angela I. León,Walter Restrepo,Angela Histopathology of cutaneous and mucosal lesions in human paracoccidioidomycosis |
| author_facet |
Uribe,Fabio Zuluaga,Angela I. León,Walter Restrepo,Angela |
| author_sort |
Uribe,Fabio |
| title |
Histopathology of cutaneous and mucosal lesions in human paracoccidioidomycosis |
| title_short |
Histopathology of cutaneous and mucosal lesions in human paracoccidioidomycosis |
| title_full |
Histopathology of cutaneous and mucosal lesions in human paracoccidioidomycosis |
| title_fullStr |
Histopathology of cutaneous and mucosal lesions in human paracoccidioidomycosis |
| title_full_unstemmed |
Histopathology of cutaneous and mucosal lesions in human paracoccidioidomycosis |
| title_sort |
histopathology of cutaneous and mucosal lesions in human paracoccidioidomycosis |
| description |
Biopsies from cutaneous and mucosal lesions from 40 patients with active paracoccidioidomycosis, were studied histopathologically. All cases exhibited chronic granulomatous inflammation and 38 also presented suppuration; this picture corresponded to the mixed mycotic granuloma (MMG). Pseudoepitheliomatous hyperplasia and the transepidermic (or epithelial) elimination of the parasite, were observed in all cases. In paracoccidioidomycosis elimination takes place through formation of progressive edema, accompained by exocytosis. The edema gives rise to spongiosis, microvesicles and microabscesses which not only contain the fungus but also, various cellular elements. Cells in charge of the phagocytic process were essentialy Langhans giant cells; PMN's, epithelioid and foreign body giant cells were poor phagocytes. An additional finding was the presence of fibrosis in most biopsies. |
| publisher |
Instituto de Medicina Tropical de São Paulo |
| publishDate |
1987 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651987000200005 |
| work_keys_str_mv |
AT uribefabio histopathologyofcutaneousandmucosallesionsinhumanparacoccidioidomycosis AT zuluagaangelai histopathologyofcutaneousandmucosallesionsinhumanparacoccidioidomycosis AT leonwalter histopathologyofcutaneousandmucosallesionsinhumanparacoccidioidomycosis AT restrepoangela histopathologyofcutaneousandmucosallesionsinhumanparacoccidioidomycosis |
| _version_ |
1756379546471366656 |