Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases
Abstract: Objective: To analyze the current knowledge of pathogen-insect interactions amenable for the design of molecular-based control strategies of vector-borne diseases. Materials and methods: We examined malaria, dengue, and Chagas disease pathogens and insect molecules that participate in interactions during their vectors infection. Results: Pathogen molecules that participate in the insect intestine invasion and induced vector immune molecules are presented, and their inclusion in transmission blocking vaccines (TBV) and in genetically modify insect (GMI) vectors or symbiotic bacteria are discussed. Conclusion: Disruption of processes by blocking vector-pathogen interactions provides several candidates for molecular control strategies, but TBV and GMI efficacies are still limited and other secondary effects of GMI (improving transmission of other pathogens, affectation of other organisms) should be discarded.
Main Authors: | , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Instituto Nacional de Salud Pública
2018
|
Online Access: | http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0036-36342018000100012 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S0036-36342018000100012 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S0036-363420180001000122018-05-24Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseasesZumaya-Estrada,Federico AlonsoRodríguez,María CarmenRodríguez,Mario Henry immunity arthropods vector control transmission Abstract: Objective: To analyze the current knowledge of pathogen-insect interactions amenable for the design of molecular-based control strategies of vector-borne diseases. Materials and methods: We examined malaria, dengue, and Chagas disease pathogens and insect molecules that participate in interactions during their vectors infection. Results: Pathogen molecules that participate in the insect intestine invasion and induced vector immune molecules are presented, and their inclusion in transmission blocking vaccines (TBV) and in genetically modify insect (GMI) vectors or symbiotic bacteria are discussed. Conclusion: Disruption of processes by blocking vector-pathogen interactions provides several candidates for molecular control strategies, but TBV and GMI efficacies are still limited and other secondary effects of GMI (improving transmission of other pathogens, affectation of other organisms) should be discarded.info:eu-repo/semantics/openAccessInstituto Nacional de Salud PúblicaSalud Pública de México v.60 n.1 20182018-02-01info:eu-repo/semantics/articletext/htmlhttp://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0036-36342018000100012en10.21149/8140 |
institution |
SCIELO |
collection |
OJS |
country |
México |
countrycode |
MX |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-mx |
tag |
revista |
region |
America del Norte |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Zumaya-Estrada,Federico Alonso Rodríguez,María Carmen Rodríguez,Mario Henry |
spellingShingle |
Zumaya-Estrada,Federico Alonso Rodríguez,María Carmen Rodríguez,Mario Henry Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases |
author_facet |
Zumaya-Estrada,Federico Alonso Rodríguez,María Carmen Rodríguez,Mario Henry |
author_sort |
Zumaya-Estrada,Federico Alonso |
title |
Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases |
title_short |
Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases |
title_full |
Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases |
title_fullStr |
Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases |
title_full_unstemmed |
Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases |
title_sort |
pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases |
description |
Abstract: Objective: To analyze the current knowledge of pathogen-insect interactions amenable for the design of molecular-based control strategies of vector-borne diseases. Materials and methods: We examined malaria, dengue, and Chagas disease pathogens and insect molecules that participate in interactions during their vectors infection. Results: Pathogen molecules that participate in the insect intestine invasion and induced vector immune molecules are presented, and their inclusion in transmission blocking vaccines (TBV) and in genetically modify insect (GMI) vectors or symbiotic bacteria are discussed. Conclusion: Disruption of processes by blocking vector-pathogen interactions provides several candidates for molecular control strategies, but TBV and GMI efficacies are still limited and other secondary effects of GMI (improving transmission of other pathogens, affectation of other organisms) should be discarded. |
publisher |
Instituto Nacional de Salud Pública |
publishDate |
2018 |
url |
http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0036-36342018000100012 |
work_keys_str_mv |
AT zumayaestradafedericoalonso pathogeninsectinteractioncandidatemoleculesfortransmissionblockingcontrolstrategiesofvectorbornediseases AT rodriguezmariacarmen pathogeninsectinteractioncandidatemoleculesfortransmissionblockingcontrolstrategiesofvectorbornediseases AT rodriguezmariohenry pathogeninsectinteractioncandidatemoleculesfortransmissionblockingcontrolstrategiesofvectorbornediseases |
_version_ |
1756220369275977728 |