Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases

Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases

Abstract: Objective: To analyze the current knowledge of pathogen-insect interactions amenable for the design of molecular-based control strategies of vector-borne diseases. Materials and methods: We examined malaria, dengue, and Chagas disease pathogens and insect molecules that participate in interactions during their vectors infection. Results: Pathogen molecules that participate in the insect intestine invasion and induced vector immune molecules are presented, and their inclusion in transmission blocking vaccines (TBV) and in genetically modify insect (GMI) vectors or symbiotic bacteria are discussed. Conclusion: Disruption of processes by blocking vector-pathogen interactions provides several candidates for molecular control strategies, but TBV and GMI efficacies are still limited and other secondary effects of GMI (improving transmission of other pathogens, affectation of other organisms) should be discarded.

Saved in:
Bibliographic Details
Main Authors: Zumaya-Estrada,Federico Alonso, Rodríguez,María Carmen, Rodríguez,Mario Henry
Format: Digital revista
Language:English
Published: Instituto Nacional de Salud Pública 2018
Online Access:http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0036-36342018000100012
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:scielo:S0036-36342018000100012
record_format ojs
spelling oai:scielo:S0036-363420180001000122018-05-24Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseasesZumaya-Estrada,Federico AlonsoRodríguez,María CarmenRodríguez,Mario Henry immunity arthropods vector control transmission Abstract: Objective: To analyze the current knowledge of pathogen-insect interactions amenable for the design of molecular-based control strategies of vector-borne diseases. Materials and methods: We examined malaria, dengue, and Chagas disease pathogens and insect molecules that participate in interactions during their vectors infection. Results: Pathogen molecules that participate in the insect intestine invasion and induced vector immune molecules are presented, and their inclusion in transmission blocking vaccines (TBV) and in genetically modify insect (GMI) vectors or symbiotic bacteria are discussed. Conclusion: Disruption of processes by blocking vector-pathogen interactions provides several candidates for molecular control strategies, but TBV and GMI efficacies are still limited and other secondary effects of GMI (improving transmission of other pathogens, affectation of other organisms) should be discarded.info:eu-repo/semantics/openAccessInstituto Nacional de Salud PúblicaSalud Pública de México v.60 n.1 20182018-02-01info:eu-repo/semantics/articletext/htmlhttp://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0036-36342018000100012en10.21149/8140
institution SCIELO
collection OJS
country México
countrycode MX
component Revista
access En linea
databasecode rev-scielo-mx
tag revista
region America del Norte
libraryname SciELO
language English
format Digital
author Zumaya-Estrada,Federico Alonso
Rodríguez,María Carmen
Rodríguez,Mario Henry
spellingShingle Zumaya-Estrada,Federico Alonso
Rodríguez,María Carmen
Rodríguez,Mario Henry
Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases
author_facet Zumaya-Estrada,Federico Alonso
Rodríguez,María Carmen
Rodríguez,Mario Henry
author_sort Zumaya-Estrada,Federico Alonso
title Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases
title_short Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases
title_full Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases
title_fullStr Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases
title_full_unstemmed Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases
title_sort pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases
description Abstract: Objective: To analyze the current knowledge of pathogen-insect interactions amenable for the design of molecular-based control strategies of vector-borne diseases. Materials and methods: We examined malaria, dengue, and Chagas disease pathogens and insect molecules that participate in interactions during their vectors infection. Results: Pathogen molecules that participate in the insect intestine invasion and induced vector immune molecules are presented, and their inclusion in transmission blocking vaccines (TBV) and in genetically modify insect (GMI) vectors or symbiotic bacteria are discussed. Conclusion: Disruption of processes by blocking vector-pathogen interactions provides several candidates for molecular control strategies, but TBV and GMI efficacies are still limited and other secondary effects of GMI (improving transmission of other pathogens, affectation of other organisms) should be discarded.
publisher Instituto Nacional de Salud Pública
publishDate 2018
url http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0036-36342018000100012
work_keys_str_mv AT zumayaestradafedericoalonso pathogeninsectinteractioncandidatemoleculesfortransmissionblockingcontrolstrategiesofvectorbornediseases
AT rodriguezmariacarmen pathogeninsectinteractioncandidatemoleculesfortransmissionblockingcontrolstrategiesofvectorbornediseases
AT rodriguezmariohenry pathogeninsectinteractioncandidatemoleculesfortransmissionblockingcontrolstrategiesofvectorbornediseases
_version_ 1756220369275977728

Similar Items