Reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthma
Background: Benzodiazepines have a direct bronchodilatory effect. Methacholine is a non-selective muscarinic receptor agonist causing bronchoconstriction. Aim: To examine the effects of inhaled benzodiazepines, modulating bronchoconstriction induced by methacholine in patients with asthma. Patients and Methods: Twelve patients with well controlled asthma were studied. On the first day, after determining the initial values of pulmonary function, a dose response curve was carried out with progressive doses of methacholine. After the last dose, when at least a 20% drop of the initial forced expiratory volume in the first second (FEV1) was achieved, vital capacity (VC) and FEV1 were measured at 7, 15 and 30 minutes after provocation. On the second day a diazepam aerosol was inhaled by the patients prior to the same protocol with methacholine. Results: In the first day of testing, methacholine inhalation (6 mg/mL) led to a significant drop in FEV1 from 2.98 to 1.69 L. On the second day of study, in the same patients, previous inhalation with diazepam reduced the changes of FEV1 after inhalation of methacholine. This parameter decreased from 2.48 to 2.21 L. Conclusions: Inhalation of benzodiazepines reduce bronchoconstriction after a methacholine challenge in patients with asthma.
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Sociedad Médica de Santiago
2016
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oai:scielo:S0034-988720160004000032016-07-01Reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthmaMiric,MirjanaRistic,SinisaJoksimovic,Bojan NMedenica,SnezanaRacic,MajaRistic,SlavicaJoksimovic,Vedrana RSkipina,Mirjana Benzodiazepines Bronchoconstriction Diazepam Methacholine Chloride Background: Benzodiazepines have a direct bronchodilatory effect. Methacholine is a non-selective muscarinic receptor agonist causing bronchoconstriction. Aim: To examine the effects of inhaled benzodiazepines, modulating bronchoconstriction induced by methacholine in patients with asthma. Patients and Methods: Twelve patients with well controlled asthma were studied. On the first day, after determining the initial values of pulmonary function, a dose response curve was carried out with progressive doses of methacholine. After the last dose, when at least a 20% drop of the initial forced expiratory volume in the first second (FEV1) was achieved, vital capacity (VC) and FEV1 were measured at 7, 15 and 30 minutes after provocation. On the second day a diazepam aerosol was inhaled by the patients prior to the same protocol with methacholine. Results: In the first day of testing, methacholine inhalation (6 mg/mL) led to a significant drop in FEV1 from 2.98 to 1.69 L. On the second day of study, in the same patients, previous inhalation with diazepam reduced the changes of FEV1 after inhalation of methacholine. This parameter decreased from 2.48 to 2.21 L. Conclusions: Inhalation of benzodiazepines reduce bronchoconstriction after a methacholine challenge in patients with asthma.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.144 n.4 20162016-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000400003en10.4067/S0034-98872016000400003 |
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Miric,Mirjana Ristic,Sinisa Joksimovic,Bojan N Medenica,Snezana Racic,Maja Ristic,Slavica Joksimovic,Vedrana R Skipina,Mirjana |
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Miric,Mirjana Ristic,Sinisa Joksimovic,Bojan N Medenica,Snezana Racic,Maja Ristic,Slavica Joksimovic,Vedrana R Skipina,Mirjana Reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthma |
author_facet |
Miric,Mirjana Ristic,Sinisa Joksimovic,Bojan N Medenica,Snezana Racic,Maja Ristic,Slavica Joksimovic,Vedrana R Skipina,Mirjana |
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Miric,Mirjana |
title |
Reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthma |
title_short |
Reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthma |
title_full |
Reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthma |
title_fullStr |
Reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthma |
title_full_unstemmed |
Reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthma |
title_sort |
reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthma |
description |
Background: Benzodiazepines have a direct bronchodilatory effect. Methacholine is a non-selective muscarinic receptor agonist causing bronchoconstriction. Aim: To examine the effects of inhaled benzodiazepines, modulating bronchoconstriction induced by methacholine in patients with asthma. Patients and Methods: Twelve patients with well controlled asthma were studied. On the first day, after determining the initial values of pulmonary function, a dose response curve was carried out with progressive doses of methacholine. After the last dose, when at least a 20% drop of the initial forced expiratory volume in the first second (FEV1) was achieved, vital capacity (VC) and FEV1 were measured at 7, 15 and 30 minutes after provocation. On the second day a diazepam aerosol was inhaled by the patients prior to the same protocol with methacholine. Results: In the first day of testing, methacholine inhalation (6 mg/mL) led to a significant drop in FEV1 from 2.98 to 1.69 L. On the second day of study, in the same patients, previous inhalation with diazepam reduced the changes of FEV1 after inhalation of methacholine. This parameter decreased from 2.48 to 2.21 L. Conclusions: Inhalation of benzodiazepines reduce bronchoconstriction after a methacholine challenge in patients with asthma. |
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Sociedad Médica de Santiago |
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2016 |
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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872016000400003 |
work_keys_str_mv |
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