Genética, HLA-B27 y espondilitis anquilosante: 40 años

Genética, HLA-B27 y espondilitis anquilosante: 40 años

Ankylosing spondylitis (AS) is a prototypical inflammatory disease of the locomotor system affecting axial skeleton. It is part of the general group of spondyloarthopathies (SpA). Its strong association with histocompatibility antigen HLA-B27 is known since 1973. However, HLA-B27 contribution to AS genetic risk is approximately 16%. Therefore, other genes are necessarily involved in the pathogenesis of the disease. Genomic development and the possibility of making genome wide screening have contributed enormously to the study of the disease. In this paper, we describe the actual knowledge about AS genetic risk, which has contributed to understand the influence of HLA-B27 on the etiology and pathogenesis of the disease. We also intend to foresee how these findings will result in an improvement of patients’ quality of life.

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Main Authors: Castro-Santos,Patricia, Gutiérrez,Miguel A, Díaz-Peña,Roberto
Format: Digital revista
Language:Spanish / Castilian
Published: Sociedad Médica de Santiago 2014
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000900011
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spelling oai:scielo:S0034-988720140009000112014-12-17Genética, HLA-B27 y espondilitis anquilosante: 40 añosCastro-Santos,PatriciaGutiérrez,Miguel ADíaz-Peña,Roberto Genetic predisposition to disease HLA-B27 antigen Spondylitis, ankylosing Ankylosing spondylitis (AS) is a prototypical inflammatory disease of the locomotor system affecting axial skeleton. It is part of the general group of spondyloarthopathies (SpA). Its strong association with histocompatibility antigen HLA-B27 is known since 1973. However, HLA-B27 contribution to AS genetic risk is approximately 16%. Therefore, other genes are necessarily involved in the pathogenesis of the disease. Genomic development and the possibility of making genome wide screening have contributed enormously to the study of the disease. In this paper, we describe the actual knowledge about AS genetic risk, which has contributed to understand the influence of HLA-B27 on the etiology and pathogenesis of the disease. We also intend to foresee how these findings will result in an improvement of patients’ quality of life.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.142 n.9 20142014-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000900011es10.4067/S0034-98872014000900011
institution SCIELO
collection OJS
country Chile
countrycode CL
component Revista
access En linea
databasecode rev-scielo-cl
tag revista
region America del Sur
libraryname SciELO
language Spanish / Castilian
format Digital
author Castro-Santos,Patricia
Gutiérrez,Miguel A
Díaz-Peña,Roberto
spellingShingle Castro-Santos,Patricia
Gutiérrez,Miguel A
Díaz-Peña,Roberto
Genética, HLA-B27 y espondilitis anquilosante: 40 años
author_facet Castro-Santos,Patricia
Gutiérrez,Miguel A
Díaz-Peña,Roberto
author_sort Castro-Santos,Patricia
title Genética, HLA-B27 y espondilitis anquilosante: 40 años
title_short Genética, HLA-B27 y espondilitis anquilosante: 40 años
title_full Genética, HLA-B27 y espondilitis anquilosante: 40 años
title_fullStr Genética, HLA-B27 y espondilitis anquilosante: 40 años
title_full_unstemmed Genética, HLA-B27 y espondilitis anquilosante: 40 años
title_sort genética, hla-b27 y espondilitis anquilosante: 40 años
description Ankylosing spondylitis (AS) is a prototypical inflammatory disease of the locomotor system affecting axial skeleton. It is part of the general group of spondyloarthopathies (SpA). Its strong association with histocompatibility antigen HLA-B27 is known since 1973. However, HLA-B27 contribution to AS genetic risk is approximately 16%. Therefore, other genes are necessarily involved in the pathogenesis of the disease. Genomic development and the possibility of making genome wide screening have contributed enormously to the study of the disease. In this paper, we describe the actual knowledge about AS genetic risk, which has contributed to understand the influence of HLA-B27 on the etiology and pathogenesis of the disease. We also intend to foresee how these findings will result in an improvement of patients’ quality of life.
publisher Sociedad Médica de Santiago
publishDate 2014
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000900011
work_keys_str_mv AT castrosantospatricia geneticahlab27yespondilitisanquilosante40anos
AT gutierrezmiguela geneticahlab27yespondilitisanquilosante40anos
AT diazpenaroberto geneticahlab27yespondilitisanquilosante40anos
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