Inmunosenescencia: pruebas cutáneas de hipersensibilidad retardada en adultos mayores chilenos autovalentes

Background: Delayed cutaneous hypersensitivity tests are a globally accepted test to assess cellular immunity in vivo. The quality and quantity of the response to these type of tests, varies in different populations. Aim: To study delayed cutaneous hypersensitivity in a group of healthy Chilean elders. Material and methods: Forty two elders (32 male), aged 60 to 76 years old were studied. Multitest-CMI® was applied in the left forearm. This test allows the subcutaneous administration of seven antigens and a glycerin control. Results were compared with those of a group of young adults studied by the authors. Results: Among males there was a mean of 2.7 ± 1.4 positive responses compared with women, that had 1.7 ± 1 positive responses (p= 0.016). The sum of response diameters was 4.2 ± 1.5 and 3.6 ± 1.9 mm in men and women respectively (p = NS). Compared to young adults, elderly women had a lower response to tetanus and diphtheria toxoids and men had a lower response to diphtheria and Proteus mirabilis. Conclusions: Elderly people have a less intense response to delayed cutaneous hypersensitivity tests than young adults. This response must be assessed in each population to account for regional variability. (Rev Méd Chile 2000; 128: 379-86).

Bibliographic Details

Main Authors:	Blackburn T,Eileen, Mur R,Paola, Jofré A,Boris, Coll C,Claudia, Jurlow M,Elizabeth
Format:	Digital revista
Language:	Spanish / Castilian
Published:	Sociedad Médica de Santiago 2000
Online Access:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000400003
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