Pleural tuberculosis: experiences from two centers in Brazil

Abstract Objective: This study aimed to describe the clinical and laboratory findings of patients diagnosed with pleural tuberculosis at two hospitals in southern Brazil. Methods: Patients aged < 18 years were evaluated retrospectively. The patients’ medical and epidemiological history, tuberculin skin test results, radiological and pathological findings, and pleural fluid analysis results were retrieved. Results: Ninety-two patients with pleural tuberculosis were identified. The mean age was 10.9 years old. Twenty-one percent were children aged six years or less. The most common symptoms were fever (88%), cough (72%), and chest pain (70%). Unilateral pleural effusion was observed in 96% of the cases. Lymphocyte predominance was found in 90% of the pleural fluid samples. The adenosine deaminase activity of the pleural fluid was greater than 40 U/L in 85% of patients. A diagnosis of community-acquired pneumonia with antibiotic prescriptions was observed in 76% of the study population. Conclusions: Tuberculosis etiology must be considered in unilateral pleural effusion in a child with contact with a case of tuberculosis. Pleural fluid biomarkers contribute to the diagnosis of pleural tuberculosis in children and adolescents.

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Main Authors: Lunelli,Magda, Ferreira,Isabel Cristina Schütz, Sarmento,Muriel Bossle, Chakr,Valentina Coutinho Baldoto Gava, Fischer,Gilberto Bueno
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Pediatria 2022
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572022000600621
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spelling oai:scielo:S0021-755720220006006212022-12-01Pleural tuberculosis: experiences from two centers in BrazilLunelli,MagdaFerreira,Isabel Cristina SchützSarmento,Muriel BossleChakr,Valentina Coutinho Baldoto GavaFischer,Gilberto Bueno Mycobacterium infection Pleural diseases Adenosine deaminase Abstract Objective: This study aimed to describe the clinical and laboratory findings of patients diagnosed with pleural tuberculosis at two hospitals in southern Brazil. Methods: Patients aged < 18 years were evaluated retrospectively. The patients’ medical and epidemiological history, tuberculin skin test results, radiological and pathological findings, and pleural fluid analysis results were retrieved. Results: Ninety-two patients with pleural tuberculosis were identified. The mean age was 10.9 years old. Twenty-one percent were children aged six years or less. The most common symptoms were fever (88%), cough (72%), and chest pain (70%). Unilateral pleural effusion was observed in 96% of the cases. Lymphocyte predominance was found in 90% of the pleural fluid samples. The adenosine deaminase activity of the pleural fluid was greater than 40 U/L in 85% of patients. A diagnosis of community-acquired pneumonia with antibiotic prescriptions was observed in 76% of the study population. Conclusions: Tuberculosis etiology must be considered in unilateral pleural effusion in a child with contact with a case of tuberculosis. Pleural fluid biomarkers contribute to the diagnosis of pleural tuberculosis in children and adolescents.info:eu-repo/semantics/openAccessSociedade Brasileira de PediatriaJornal de Pediatria v.98 n.6 20222022-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572022000600621en10.1016/j.jped.2022.03.006
institution SCIELO
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country Brasil
countrycode BR
component Revista
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databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Lunelli,Magda
Ferreira,Isabel Cristina Schütz
Sarmento,Muriel Bossle
Chakr,Valentina Coutinho Baldoto Gava
Fischer,Gilberto Bueno
spellingShingle Lunelli,Magda
Ferreira,Isabel Cristina Schütz
Sarmento,Muriel Bossle
Chakr,Valentina Coutinho Baldoto Gava
Fischer,Gilberto Bueno
Pleural tuberculosis: experiences from two centers in Brazil
author_facet Lunelli,Magda
Ferreira,Isabel Cristina Schütz
Sarmento,Muriel Bossle
Chakr,Valentina Coutinho Baldoto Gava
Fischer,Gilberto Bueno
author_sort Lunelli,Magda
title Pleural tuberculosis: experiences from two centers in Brazil
title_short Pleural tuberculosis: experiences from two centers in Brazil
title_full Pleural tuberculosis: experiences from two centers in Brazil
title_fullStr Pleural tuberculosis: experiences from two centers in Brazil
title_full_unstemmed Pleural tuberculosis: experiences from two centers in Brazil
title_sort pleural tuberculosis: experiences from two centers in brazil
description Abstract Objective: This study aimed to describe the clinical and laboratory findings of patients diagnosed with pleural tuberculosis at two hospitals in southern Brazil. Methods: Patients aged < 18 years were evaluated retrospectively. The patients’ medical and epidemiological history, tuberculin skin test results, radiological and pathological findings, and pleural fluid analysis results were retrieved. Results: Ninety-two patients with pleural tuberculosis were identified. The mean age was 10.9 years old. Twenty-one percent were children aged six years or less. The most common symptoms were fever (88%), cough (72%), and chest pain (70%). Unilateral pleural effusion was observed in 96% of the cases. Lymphocyte predominance was found in 90% of the pleural fluid samples. The adenosine deaminase activity of the pleural fluid was greater than 40 U/L in 85% of patients. A diagnosis of community-acquired pneumonia with antibiotic prescriptions was observed in 76% of the study population. Conclusions: Tuberculosis etiology must be considered in unilateral pleural effusion in a child with contact with a case of tuberculosis. Pleural fluid biomarkers contribute to the diagnosis of pleural tuberculosis in children and adolescents.
publisher Sociedade Brasileira de Pediatria
publishDate 2022
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572022000600621
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