The poor insane Ophelia: reconsidering Ophelia syndrome
ABSTRACT The association between memory loss and Hodgkin's lymphoma has been given the eponym of Ophelia syndrome, in memory of Shakespeare's character in The Tragedy of Hamlet, Prince of Denmark. Nevertheless, there are differences between the disease and the character. Objective: To review the origins and uses of the eponym through an original article by pathologist Ian Carr, its relation to the character Ophelia, and the related autoantibodies. Methods: Historical narrative review. Results: Besides an eloquent description in the original article, Carr presaged the presence of autoantibodies, before they had been thoroughly researched. Since then, five different autoantibodies (mGluR5, Hu, NMDAR, SOX, PCA2) have been associated with Hodgkin's disease. It is interesting to note the divergent outcomes of Shakespeare's character and the patient in the original description by Carr, the latter recovering to lead a normal life, and the former deceased. Conclusions: Although there is little relationship between the fictional character and the syndrome, both imply the unintentional trigger of self-harm (suicide in one case, autoimmunity in the other), thus remaining associated.
Main Authors: | , , , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Academia Brasileira de Neurologia - ABNEURO
2019
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019001100828 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S0004-282X2019001100828 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S0004-282X20190011008282019-12-12The poor insane Ophelia: reconsidering Ophelia syndromeSoto-Rincón,Carlos A.Castillo-Torres,Sergio A.Cantú-García,Diego A.Estrada-Bellmann,IngridChávez-Luévanos,BeatrizMarfil,Alejandro Limbic encephalitis Hodgkin disease ABSTRACT The association between memory loss and Hodgkin's lymphoma has been given the eponym of Ophelia syndrome, in memory of Shakespeare's character in The Tragedy of Hamlet, Prince of Denmark. Nevertheless, there are differences between the disease and the character. Objective: To review the origins and uses of the eponym through an original article by pathologist Ian Carr, its relation to the character Ophelia, and the related autoantibodies. Methods: Historical narrative review. Results: Besides an eloquent description in the original article, Carr presaged the presence of autoantibodies, before they had been thoroughly researched. Since then, five different autoantibodies (mGluR5, Hu, NMDAR, SOX, PCA2) have been associated with Hodgkin's disease. It is interesting to note the divergent outcomes of Shakespeare's character and the patient in the original description by Carr, the latter recovering to lead a normal life, and the former deceased. Conclusions: Although there is little relationship between the fictional character and the syndrome, both imply the unintentional trigger of self-harm (suicide in one case, autoimmunity in the other), thus remaining associated.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.77 n.11 20192019-11-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019001100828en10.1590/0004-282x20190105 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Soto-Rincón,Carlos A. Castillo-Torres,Sergio A. Cantú-García,Diego A. Estrada-Bellmann,Ingrid Chávez-Luévanos,Beatriz Marfil,Alejandro |
spellingShingle |
Soto-Rincón,Carlos A. Castillo-Torres,Sergio A. Cantú-García,Diego A. Estrada-Bellmann,Ingrid Chávez-Luévanos,Beatriz Marfil,Alejandro The poor insane Ophelia: reconsidering Ophelia syndrome |
author_facet |
Soto-Rincón,Carlos A. Castillo-Torres,Sergio A. Cantú-García,Diego A. Estrada-Bellmann,Ingrid Chávez-Luévanos,Beatriz Marfil,Alejandro |
author_sort |
Soto-Rincón,Carlos A. |
title |
The poor insane Ophelia: reconsidering Ophelia syndrome |
title_short |
The poor insane Ophelia: reconsidering Ophelia syndrome |
title_full |
The poor insane Ophelia: reconsidering Ophelia syndrome |
title_fullStr |
The poor insane Ophelia: reconsidering Ophelia syndrome |
title_full_unstemmed |
The poor insane Ophelia: reconsidering Ophelia syndrome |
title_sort |
poor insane ophelia: reconsidering ophelia syndrome |
description |
ABSTRACT The association between memory loss and Hodgkin's lymphoma has been given the eponym of Ophelia syndrome, in memory of Shakespeare's character in The Tragedy of Hamlet, Prince of Denmark. Nevertheless, there are differences between the disease and the character. Objective: To review the origins and uses of the eponym through an original article by pathologist Ian Carr, its relation to the character Ophelia, and the related autoantibodies. Methods: Historical narrative review. Results: Besides an eloquent description in the original article, Carr presaged the presence of autoantibodies, before they had been thoroughly researched. Since then, five different autoantibodies (mGluR5, Hu, NMDAR, SOX, PCA2) have been associated with Hodgkin's disease. It is interesting to note the divergent outcomes of Shakespeare's character and the patient in the original description by Carr, the latter recovering to lead a normal life, and the former deceased. Conclusions: Although there is little relationship between the fictional character and the syndrome, both imply the unintentional trigger of self-harm (suicide in one case, autoimmunity in the other), thus remaining associated. |
publisher |
Academia Brasileira de Neurologia - ABNEURO |
publishDate |
2019 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019001100828 |
work_keys_str_mv |
AT sotorinconcarlosa thepoorinsaneopheliareconsideringopheliasyndrome AT castillotorressergioa thepoorinsaneopheliareconsideringopheliasyndrome AT cantugarciadiegoa thepoorinsaneopheliareconsideringopheliasyndrome AT estradabellmanningrid thepoorinsaneopheliareconsideringopheliasyndrome AT chavezluevanosbeatriz thepoorinsaneopheliareconsideringopheliasyndrome AT marfilalejandro thepoorinsaneopheliareconsideringopheliasyndrome AT sotorinconcarlosa poorinsaneopheliareconsideringopheliasyndrome AT castillotorressergioa poorinsaneopheliareconsideringopheliasyndrome AT cantugarciadiegoa poorinsaneopheliareconsideringopheliasyndrome AT estradabellmanningrid poorinsaneopheliareconsideringopheliasyndrome AT chavezluevanosbeatriz poorinsaneopheliareconsideringopheliasyndrome AT marfilalejandro poorinsaneopheliareconsideringopheliasyndrome |
_version_ |
1756374784855244800 |