Genes related to maintenance of autophagy and successful aging
ABSTRACT Considering aging as a phenomenon in which there is a decline in essential processes for cell survival, we investigated the autophagic and proteasome pathways in three different groups: young, older and oldest old male adults. The expression profile of autophagic pathway-related genes was carried out in peripheral blood, and the proteasome quantification was performed in plasma. No significant changes were found in plasma proteasome concentrations or in correlations between proteasome concentrations and ages. However, some autophagy- and/or apoptosis-related genes were differentially expressed. In addition, the network and enrichment analysis showed an interaction between four of the five differentially expressed genes and an association of these genes with the transcriptional process. Considering that the oldest old individuals maintained both the expression of genes linked to the autophagic machinery, and the proteasome levels, when compared with the older group, we concluded that these factors could be considered crucial for successful aging.
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Academia Brasileira de Neurologia - ABNEURO
2018
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oai:scielo:S0004-282X20180012008312019-01-18Genes related to maintenance of autophagy and successful agingChaves,Carolina FiorotoMazzotti,Diego RoblesCendoroglo,Maysa SeabraRamos,Luiz RobertoTufik,SergioSilva,Vanessa Cavalcante daD'Almeida,Vânia Autophagy longevity gene expression gene networks proteasome endopeptidase complex ABSTRACT Considering aging as a phenomenon in which there is a decline in essential processes for cell survival, we investigated the autophagic and proteasome pathways in three different groups: young, older and oldest old male adults. The expression profile of autophagic pathway-related genes was carried out in peripheral blood, and the proteasome quantification was performed in plasma. No significant changes were found in plasma proteasome concentrations or in correlations between proteasome concentrations and ages. However, some autophagy- and/or apoptosis-related genes were differentially expressed. In addition, the network and enrichment analysis showed an interaction between four of the five differentially expressed genes and an association of these genes with the transcriptional process. Considering that the oldest old individuals maintained both the expression of genes linked to the autophagic machinery, and the proteasome levels, when compared with the older group, we concluded that these factors could be considered crucial for successful aging.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.76 n.12 20182018-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018001200831en10.1590/0004-282x20180142 |
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Chaves,Carolina Fioroto Mazzotti,Diego Robles Cendoroglo,Maysa Seabra Ramos,Luiz Roberto Tufik,Sergio Silva,Vanessa Cavalcante da D'Almeida,Vânia |
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Chaves,Carolina Fioroto Mazzotti,Diego Robles Cendoroglo,Maysa Seabra Ramos,Luiz Roberto Tufik,Sergio Silva,Vanessa Cavalcante da D'Almeida,Vânia Genes related to maintenance of autophagy and successful aging |
author_facet |
Chaves,Carolina Fioroto Mazzotti,Diego Robles Cendoroglo,Maysa Seabra Ramos,Luiz Roberto Tufik,Sergio Silva,Vanessa Cavalcante da D'Almeida,Vânia |
author_sort |
Chaves,Carolina Fioroto |
title |
Genes related to maintenance of autophagy and successful aging |
title_short |
Genes related to maintenance of autophagy and successful aging |
title_full |
Genes related to maintenance of autophagy and successful aging |
title_fullStr |
Genes related to maintenance of autophagy and successful aging |
title_full_unstemmed |
Genes related to maintenance of autophagy and successful aging |
title_sort |
genes related to maintenance of autophagy and successful aging |
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ABSTRACT Considering aging as a phenomenon in which there is a decline in essential processes for cell survival, we investigated the autophagic and proteasome pathways in three different groups: young, older and oldest old male adults. The expression profile of autophagic pathway-related genes was carried out in peripheral blood, and the proteasome quantification was performed in plasma. No significant changes were found in plasma proteasome concentrations or in correlations between proteasome concentrations and ages. However, some autophagy- and/or apoptosis-related genes were differentially expressed. In addition, the network and enrichment analysis showed an interaction between four of the five differentially expressed genes and an association of these genes with the transcriptional process. Considering that the oldest old individuals maintained both the expression of genes linked to the autophagic machinery, and the proteasome levels, when compared with the older group, we concluded that these factors could be considered crucial for successful aging. |
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Academia Brasileira de Neurologia - ABNEURO |
publishDate |
2018 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018001200831 |
work_keys_str_mv |
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1756374762458710016 |