The rs3857059 variant of the SNCA gene is associated with Parkinson’s disease in Mexican Mestizos
ABSTRACT Among the candidate genes for Parkinson’s disease (PD), SNCA has replicated association in different populations. Besides other known mutations in the SNCA gene, the rs3857059 variant has also been linked to various neurodegenerative disorders. Therefore, the aim of the present study was to search for association of this variant and sporadic PD in Mexican Mestizo patients. A case-control study was performed including 241 individuals, 106 patients, and 135 healthy controls. Genotyping was performed using real-time PCR. The rs3857059 variant demonstrated an association with PD in Mexican Mestizos (OR = 2.40, CI, 1.1 to 5.1, p = 0.02) under the recessive model. In addition, a gender effect was found for the GG genotype in females (OR = 1.31, CI, 1.01 to 1.7, p = 0.037). This is the first study to confirm an association of the rs3857059 variant with PD and also to show a gender effect. Our data contribute to the elucidation of the link between rs3857059 and susceptibility to PD observed in the Mexican Mestizo population.
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Academia Brasileira de Neurologia - ABNEURO
2016
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oai:scielo:S0004-282X20160006004452017-01-11The rs3857059 variant of the SNCA gene is associated with Parkinson’s disease in Mexican MestizosGarcía,S.Chavira-Hernández,G.Gallegos-Arreola,M.P.Dávila-Maldonado,L.García Martínez,F.Montes Almanza,L.A.Palma-Flores,C.Mondragón-Terán,P.Alcaraz Estrada,S.L.López-Hernández,L. B. Parkinson disease genes SNCA genetics ABSTRACT Among the candidate genes for Parkinson’s disease (PD), SNCA has replicated association in different populations. Besides other known mutations in the SNCA gene, the rs3857059 variant has also been linked to various neurodegenerative disorders. Therefore, the aim of the present study was to search for association of this variant and sporadic PD in Mexican Mestizo patients. A case-control study was performed including 241 individuals, 106 patients, and 135 healthy controls. Genotyping was performed using real-time PCR. The rs3857059 variant demonstrated an association with PD in Mexican Mestizos (OR = 2.40, CI, 1.1 to 5.1, p = 0.02) under the recessive model. In addition, a gender effect was found for the GG genotype in females (OR = 1.31, CI, 1.01 to 1.7, p = 0.037). This is the first study to confirm an association of the rs3857059 variant with PD and also to show a gender effect. Our data contribute to the elucidation of the link between rs3857059 and susceptibility to PD observed in the Mexican Mestizo population.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.74 n.6 20162016-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000600445en10.1590/0004-282x20160061 |
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García,S. Chavira-Hernández,G. Gallegos-Arreola,M.P. Dávila-Maldonado,L. García Martínez,F. Montes Almanza,L.A. Palma-Flores,C. Mondragón-Terán,P. Alcaraz Estrada,S.L. López-Hernández,L. B. |
spellingShingle |
García,S. Chavira-Hernández,G. Gallegos-Arreola,M.P. Dávila-Maldonado,L. García Martínez,F. Montes Almanza,L.A. Palma-Flores,C. Mondragón-Terán,P. Alcaraz Estrada,S.L. López-Hernández,L. B. The rs3857059 variant of the SNCA gene is associated with Parkinson’s disease in Mexican Mestizos |
author_facet |
García,S. Chavira-Hernández,G. Gallegos-Arreola,M.P. Dávila-Maldonado,L. García Martínez,F. Montes Almanza,L.A. Palma-Flores,C. Mondragón-Terán,P. Alcaraz Estrada,S.L. López-Hernández,L. B. |
author_sort |
García,S. |
title |
The rs3857059 variant of the SNCA gene is associated with Parkinson’s disease in Mexican Mestizos |
title_short |
The rs3857059 variant of the SNCA gene is associated with Parkinson’s disease in Mexican Mestizos |
title_full |
The rs3857059 variant of the SNCA gene is associated with Parkinson’s disease in Mexican Mestizos |
title_fullStr |
The rs3857059 variant of the SNCA gene is associated with Parkinson’s disease in Mexican Mestizos |
title_full_unstemmed |
The rs3857059 variant of the SNCA gene is associated with Parkinson’s disease in Mexican Mestizos |
title_sort |
rs3857059 variant of the snca gene is associated with parkinson’s disease in mexican mestizos |
description |
ABSTRACT Among the candidate genes for Parkinson’s disease (PD), SNCA has replicated association in different populations. Besides other known mutations in the SNCA gene, the rs3857059 variant has also been linked to various neurodegenerative disorders. Therefore, the aim of the present study was to search for association of this variant and sporadic PD in Mexican Mestizo patients. A case-control study was performed including 241 individuals, 106 patients, and 135 healthy controls. Genotyping was performed using real-time PCR. The rs3857059 variant demonstrated an association with PD in Mexican Mestizos (OR = 2.40, CI, 1.1 to 5.1, p = 0.02) under the recessive model. In addition, a gender effect was found for the GG genotype in females (OR = 1.31, CI, 1.01 to 1.7, p = 0.037). This is the first study to confirm an association of the rs3857059 variant with PD and also to show a gender effect. Our data contribute to the elucidation of the link between rs3857059 and susceptibility to PD observed in the Mexican Mestizo population. |
publisher |
Academia Brasileira de Neurologia - ABNEURO |
publishDate |
2016 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000600445 |
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