Primary neural leprosy: systematic review

Primary neural leprosy: systematic review

The authors proposed a systematic review on the current concepts of primary neural leprosy by consulting the following online databases: MEDLINE, Lilacs/SciELO, and Embase. Selected studies were classified based on the degree of recommendation and levels of scientific evidence according to the “Oxford Centre for Evidence-based Medicine”. The following aspects were reviewed: cutaneous clinical and laboratorial investigations, i.e. skin clinical exam, smears, and biopsy, and Mitsuda's reaction; neurological investigation (anamnesis, electromyography and nerve biopsy); serological investigation and molecular testing, i.e. serological testing for the detection of the phenolic glycolipid 1 (PGL-I) and the polymerase chain reaction (PCR); and treatment (classification criteria for the definition of specific treatment, steroid treatment, and cure criteria).

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Bibliographic Details
Main Authors: Garbino,Jose Antonio, Marques Jr,Wilson, Barreto,Jaison Antonio, Heise,Carlos Otto, Rodrigues,Marcia Maria Jardim, Antunes,Sergio L., Soares,Cleverson Teixeira, Floriano,Marcos Cesar, Nery,Jose Augusto, Trindade,Maria Angela Bianconcini, Carvalho,Noemia Barbosa, Andrada,Nathalia Carvalho de, Barreira,Amilton Antunes, Virmond,Marcos da Cunha Lopes
Format: Digital revista
Language:English
Published: Academia Brasileira de Neurologia - ABNEURO 2013
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000600397
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Summary:The authors proposed a systematic review on the current concepts of primary neural leprosy by consulting the following online databases: MEDLINE, Lilacs/SciELO, and Embase. Selected studies were classified based on the degree of recommendation and levels of scientific evidence according to the “Oxford Centre for Evidence-based Medicine”. The following aspects were reviewed: cutaneous clinical and laboratorial investigations, i.e. skin clinical exam, smears, and biopsy, and Mitsuda's reaction; neurological investigation (anamnesis, electromyography and nerve biopsy); serological investigation and molecular testing, i.e. serological testing for the detection of the phenolic glycolipid 1 (PGL-I) and the polymerase chain reaction (PCR); and treatment (classification criteria for the definition of specific treatment, steroid treatment, and cure criteria).

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