Psychiatric disorders in patients with systemic lupus erythematosus

Background The frequency of psychiatric disorders associated with systemic lupus erythematosus (SLE) is variable. Objective To identify the psychiatric disorders of patients with SLE. Methods The Mini International Neuropsychiatric Interview Plus was used in 131 women for the diagnosis of psychiatric disorders related with age, time and activity of the disease (SLEDAI-2K). Eighty women with SLE and 60 healthy women were genotyped by polymerase chain reaction. In 113 patients, the SF-36 was evaluated. Results Major depressive episode (37.4%), Agorafobia (45.0%) and generalized anxiety disorder (34.4%) were the most common findings. Activity of the SLE was significantly associated with the presence of humor disorders, disorders of anxiety and suicide risk (p<0.05). Humor disorders, anxiety disorders and suicide risk presented greater tendency to the G/G genotype. The domains of SF-36 for physical function, vitality and mental health had significant results for all the disorders (p<0.05). Conclusions The activity of the SLE represented risk for the presence of humor and anxiety disorders. This study has presented evidences of the association between polymorphism in the promoter – 174 G/C of the gene IL-6. All SF-36 domains were shown to be related with psychiatric disorders.

Bibliographic Details

Main Author:	Asano,Nadja Maria Jorge
Format:	Digital revista
Language:	English
Published:	Academia Brasileira de Neurologia - ABNEURO 2013
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000300200
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