Merosin-positive congenital muscular dystrophy: neuroimaging findings
Congenital muscle dystrophy (CMD) is a heterogeneous group of autosomal recessive myopathies. It is known that CMD may affect the central nervous system (CNS). Some authors have shown that merosin-negative CMD patients may have encephalic metabolic disturbances. In order to study metabolic changes within the brain, the authors performed a magnetic resonance spectroscopy (MRS) study in a 1-year-old girl with merosin-positive CMD (MP-CMD). MRS of brain demonstrated that NAA/Cr ratio was decreased (1.52), while Cho/Cr ratio was increased (1.78). These findings suggest that metabolic changes in CNS can also be found in patients with MP-CMD.
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Academia Brasileira de Neurologia - ABNEURO
2007
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oai:scielo:S0004-282X20070001000352007-03-23Merosin-positive congenital muscular dystrophy: neuroimaging findingsMatta,André Palma da CunhaGonsalves,Márcia de Castro Diniz congenital muscle dystrophy merosin magnetic resonance Congenital muscle dystrophy (CMD) is a heterogeneous group of autosomal recessive myopathies. It is known that CMD may affect the central nervous system (CNS). Some authors have shown that merosin-negative CMD patients may have encephalic metabolic disturbances. In order to study metabolic changes within the brain, the authors performed a magnetic resonance spectroscopy (MRS) study in a 1-year-old girl with merosin-positive CMD (MP-CMD). MRS of brain demonstrated that NAA/Cr ratio was decreased (1.52), while Cho/Cr ratio was increased (1.78). These findings suggest that metabolic changes in CNS can also be found in patients with MP-CMD.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.65 n.1 20072007-03-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000100035en10.1590/S0004-282X2007000100035 |
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Matta,André Palma da Cunha Gonsalves,Márcia de Castro Diniz |
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Matta,André Palma da Cunha Gonsalves,Márcia de Castro Diniz Merosin-positive congenital muscular dystrophy: neuroimaging findings |
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Matta,André Palma da Cunha Gonsalves,Márcia de Castro Diniz |
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Matta,André Palma da Cunha |
title |
Merosin-positive congenital muscular dystrophy: neuroimaging findings |
title_short |
Merosin-positive congenital muscular dystrophy: neuroimaging findings |
title_full |
Merosin-positive congenital muscular dystrophy: neuroimaging findings |
title_fullStr |
Merosin-positive congenital muscular dystrophy: neuroimaging findings |
title_full_unstemmed |
Merosin-positive congenital muscular dystrophy: neuroimaging findings |
title_sort |
merosin-positive congenital muscular dystrophy: neuroimaging findings |
description |
Congenital muscle dystrophy (CMD) is a heterogeneous group of autosomal recessive myopathies. It is known that CMD may affect the central nervous system (CNS). Some authors have shown that merosin-negative CMD patients may have encephalic metabolic disturbances. In order to study metabolic changes within the brain, the authors performed a magnetic resonance spectroscopy (MRS) study in a 1-year-old girl with merosin-positive CMD (MP-CMD). MRS of brain demonstrated that NAA/Cr ratio was decreased (1.52), while Cho/Cr ratio was increased (1.78). These findings suggest that metabolic changes in CNS can also be found in patients with MP-CMD. |
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Academia Brasileira de Neurologia - ABNEURO |
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2007 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000100035 |
work_keys_str_mv |
AT mattaandrepalmadacunha merosinpositivecongenitalmusculardystrophyneuroimagingfindings AT gonsalvesmarciadecastrodiniz merosinpositivecongenitalmusculardystrophyneuroimagingfindings |
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1756374363116929024 |