Merosin-positive congenital muscular dystrophy: neuroimaging findings

Merosin-positive congenital muscular dystrophy: neuroimaging findings

Congenital muscle dystrophy (CMD) is a heterogeneous group of autosomal recessive myopathies. It is known that CMD may affect the central nervous system (CNS). Some authors have shown that merosin-negative CMD patients may have encephalic metabolic disturbances. In order to study metabolic changes within the brain, the authors performed a magnetic resonance spectroscopy (MRS) study in a 1-year-old girl with merosin-positive CMD (MP-CMD). MRS of brain demonstrated that NAA/Cr ratio was decreased (1.52), while Cho/Cr ratio was increased (1.78). These findings suggest that metabolic changes in CNS can also be found in patients with MP-CMD.

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Main Authors: Matta,André Palma da Cunha, Gonsalves,Márcia de Castro Diniz
Format: Digital revista
Language:English
Published: Academia Brasileira de Neurologia - ABNEURO 2007
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000100035
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spelling oai:scielo:S0004-282X20070001000352007-03-23Merosin-positive congenital muscular dystrophy: neuroimaging findingsMatta,André Palma da CunhaGonsalves,Márcia de Castro Diniz congenital muscle dystrophy merosin magnetic resonance Congenital muscle dystrophy (CMD) is a heterogeneous group of autosomal recessive myopathies. It is known that CMD may affect the central nervous system (CNS). Some authors have shown that merosin-negative CMD patients may have encephalic metabolic disturbances. In order to study metabolic changes within the brain, the authors performed a magnetic resonance spectroscopy (MRS) study in a 1-year-old girl with merosin-positive CMD (MP-CMD). MRS of brain demonstrated that NAA/Cr ratio was decreased (1.52), while Cho/Cr ratio was increased (1.78). These findings suggest that metabolic changes in CNS can also be found in patients with MP-CMD.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.65 n.1 20072007-03-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000100035en10.1590/S0004-282X2007000100035
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Matta,André Palma da Cunha
Gonsalves,Márcia de Castro Diniz
spellingShingle Matta,André Palma da Cunha
Gonsalves,Márcia de Castro Diniz
Merosin-positive congenital muscular dystrophy: neuroimaging findings
author_facet Matta,André Palma da Cunha
Gonsalves,Márcia de Castro Diniz
author_sort Matta,André Palma da Cunha
title Merosin-positive congenital muscular dystrophy: neuroimaging findings
title_short Merosin-positive congenital muscular dystrophy: neuroimaging findings
title_full Merosin-positive congenital muscular dystrophy: neuroimaging findings
title_fullStr Merosin-positive congenital muscular dystrophy: neuroimaging findings
title_full_unstemmed Merosin-positive congenital muscular dystrophy: neuroimaging findings
title_sort merosin-positive congenital muscular dystrophy: neuroimaging findings
description Congenital muscle dystrophy (CMD) is a heterogeneous group of autosomal recessive myopathies. It is known that CMD may affect the central nervous system (CNS). Some authors have shown that merosin-negative CMD patients may have encephalic metabolic disturbances. In order to study metabolic changes within the brain, the authors performed a magnetic resonance spectroscopy (MRS) study in a 1-year-old girl with merosin-positive CMD (MP-CMD). MRS of brain demonstrated that NAA/Cr ratio was decreased (1.52), while Cho/Cr ratio was increased (1.78). These findings suggest that metabolic changes in CNS can also be found in patients with MP-CMD.
publisher Academia Brasileira de Neurologia - ABNEURO
publishDate 2007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000100035
work_keys_str_mv AT mattaandrepalmadacunha merosinpositivecongenitalmusculardystrophyneuroimagingfindings
AT gonsalvesmarciadecastrodiniz merosinpositivecongenitalmusculardystrophyneuroimagingfindings
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