Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk
Cutaneous rash is one of the commonest adverse events associated with lamotrigine. We assessed whether the risk is increased in patients receiving concomitant valproate therapy in a population of 103 adult patients with intractable epilepsy, who had lamotrigine added to their treatment. Of the 33 patients taking valproate, 10 (30%) developed a rash, whilst of the 70 not taking valproate, only 6 (8%) developed a rash. This suggests a significantly higher risk of cutaneous rash when starting lamotrigine in patients already taking valproate (p<0.02).
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Academia Brasileira de Neurologia - ABNEURO
1996
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oai:scielo:S0004-282X19960001000082010-12-07Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased riskLi,L. M.Russo,M.O'Donoghue,M. F.Duncan,J. S.Sander,J. W. A. S. allergic skin rash antiepileptic drugs lamotrigine valproate Cutaneous rash is one of the commonest adverse events associated with lamotrigine. We assessed whether the risk is increased in patients receiving concomitant valproate therapy in a population of 103 adult patients with intractable epilepsy, who had lamotrigine added to their treatment. Of the 33 patients taking valproate, 10 (30%) developed a rash, whilst of the 70 not taking valproate, only 6 (8%) developed a rash. This suggests a significantly higher risk of cutaneous rash when starting lamotrigine in patients already taking valproate (p<0.02).info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.54 n.1 19961996-03-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1996000100008en10.1590/S0004-282X1996000100008 |
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revista |
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| author |
Li,L. M. Russo,M. O'Donoghue,M. F. Duncan,J. S. Sander,J. W. A. S. |
| spellingShingle |
Li,L. M. Russo,M. O'Donoghue,M. F. Duncan,J. S. Sander,J. W. A. S. Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk |
| author_facet |
Li,L. M. Russo,M. O'Donoghue,M. F. Duncan,J. S. Sander,J. W. A. S. |
| author_sort |
Li,L. M. |
| title |
Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk |
| title_short |
Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk |
| title_full |
Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk |
| title_fullStr |
Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk |
| title_full_unstemmed |
Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk |
| title_sort |
allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk |
| description |
Cutaneous rash is one of the commonest adverse events associated with lamotrigine. We assessed whether the risk is increased in patients receiving concomitant valproate therapy in a population of 103 adult patients with intractable epilepsy, who had lamotrigine added to their treatment. Of the 33 patients taking valproate, 10 (30%) developed a rash, whilst of the 70 not taking valproate, only 6 (8%) developed a rash. This suggests a significantly higher risk of cutaneous rash when starting lamotrigine in patients already taking valproate (p<0.02). |
| publisher |
Academia Brasileira de Neurologia - ABNEURO |
| publishDate |
1996 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1996000100008 |
| work_keys_str_mv |
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| _version_ |
1756374043374649344 |