Histological and histochemical changes of the skeletal muscle in human chronic Chagas' disease

Histological and histochemical changes of the skeletal muscle in human chronic Chagas' disease

Gastrocnemius muscle biopsies were performed in 7 subjects with chronic Chagas' disease. On clinical and laboratory grounds the selected patients were judged to be healthy, being the only abnormality found the presence of positive serum tests for Chagas' disease. Fibre type grouping of either type I or type II was observed in 5 of the 7 patients. Furthermore, in 2 of the 5 patients showing muscle fibre groupings, angular fibres reacting with NADH and non-specific sterase were also found. These observations strongly suggest denervation associated with reinervation. This picture often can be observed in the skeletal muscle of patients with well compensated denervatory conditions who do not show clinical evidences of denervation.

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Main Authors: Taratuto,Analia, Pagano,M. A., Fumo,Teresa, Sanz,Olga P., Sica,R. E. P.
Format: Digital revista
Language:English
Published: Academia Brasileira de Neurologia - ABNEURO 1978
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1978000400006
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spelling oai:scielo:S0004-282X19780004000062012-08-27Histological and histochemical changes of the skeletal muscle in human chronic Chagas' diseaseTaratuto,AnaliaPagano,M. A.Fumo,TeresaSanz,Olga P.Sica,R. E. P.Gastrocnemius muscle biopsies were performed in 7 subjects with chronic Chagas' disease. On clinical and laboratory grounds the selected patients were judged to be healthy, being the only abnormality found the presence of positive serum tests for Chagas' disease. Fibre type grouping of either type I or type II was observed in 5 of the 7 patients. Furthermore, in 2 of the 5 patients showing muscle fibre groupings, angular fibres reacting with NADH and non-specific sterase were also found. These observations strongly suggest denervation associated with reinervation. This picture often can be observed in the skeletal muscle of patients with well compensated denervatory conditions who do not show clinical evidences of denervation.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.36 n.4 19781978-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1978000400006en10.1590/S0004-282X1978000400006
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country Brasil
countrycode BR
component Revista
access En linea
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region America del Sur
libraryname SciELO
language English
format Digital
author Taratuto,Analia
Pagano,M. A.
Fumo,Teresa
Sanz,Olga P.
Sica,R. E. P.
spellingShingle Taratuto,Analia
Pagano,M. A.
Fumo,Teresa
Sanz,Olga P.
Sica,R. E. P.
Histological and histochemical changes of the skeletal muscle in human chronic Chagas' disease
author_facet Taratuto,Analia
Pagano,M. A.
Fumo,Teresa
Sanz,Olga P.
Sica,R. E. P.
author_sort Taratuto,Analia
title Histological and histochemical changes of the skeletal muscle in human chronic Chagas' disease
title_short Histological and histochemical changes of the skeletal muscle in human chronic Chagas' disease
title_full Histological and histochemical changes of the skeletal muscle in human chronic Chagas' disease
title_fullStr Histological and histochemical changes of the skeletal muscle in human chronic Chagas' disease
title_full_unstemmed Histological and histochemical changes of the skeletal muscle in human chronic Chagas' disease
title_sort histological and histochemical changes of the skeletal muscle in human chronic chagas' disease
description Gastrocnemius muscle biopsies were performed in 7 subjects with chronic Chagas' disease. On clinical and laboratory grounds the selected patients were judged to be healthy, being the only abnormality found the presence of positive serum tests for Chagas' disease. Fibre type grouping of either type I or type II was observed in 5 of the 7 patients. Furthermore, in 2 of the 5 patients showing muscle fibre groupings, angular fibres reacting with NADH and non-specific sterase were also found. These observations strongly suggest denervation associated with reinervation. This picture often can be observed in the skeletal muscle of patients with well compensated denervatory conditions who do not show clinical evidences of denervation.
publisher Academia Brasileira de Neurologia - ABNEURO
publishDate 1978
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1978000400006
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