The unusual association of Graves' disease, chronic spontaneous urticaria, and premature ovarian failure: report of a case and HLA haplotype characterization
Chronic spontaneous urticaria (CSU), defined as the occurrence of spontaneous wheals for more than six weeks, has been associated with autoimmune diseases. Herein, we report the unusual association of CSU, Graves' disease, and premature ovarian failure. Human leukocyte antigen (HLA) studies were performed. A 36-year-old woman presented symptoms and signs of hyperthyroidism for three months. In the same period, the patient complained of widespread urticarial wheals, intensely itchy, and poorly responsive to therapy with antihistaminic agents. Hyperthyroidism was confirmed biochemically, and treatment with methimazole was started. As hyperthyroidism improved, a marked improvement in her urticaria was also observed. However, the patient continued to complain of amenorrhea. Endocrine evaluation, at the age 38, was consistent with premature ovarian failure. This is the first report of coexistence of GD, CSU, and POF. The genetic background of such unusual association is a specific combination of HLA.
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Sociedade Brasileira de Endocrinologia e Metabologia
2013
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oai:scielo:S0004-273020130009000132014-03-27The unusual association of Graves' disease, chronic spontaneous urticaria, and premature ovarian failure: report of a case and HLA haplotype characterizationRuggeri,Rosaria MaddalenaVita,GiuseppeD'Angelo,Anna GraziaQuattrocchi,PaolinaCerto,RosariaBenvenga,SalvatoreCannavò,SalvatoreGangemi,SebastianoChronic spontaneous urticaria (CSU), defined as the occurrence of spontaneous wheals for more than six weeks, has been associated with autoimmune diseases. Herein, we report the unusual association of CSU, Graves' disease, and premature ovarian failure. Human leukocyte antigen (HLA) studies were performed. A 36-year-old woman presented symptoms and signs of hyperthyroidism for three months. In the same period, the patient complained of widespread urticarial wheals, intensely itchy, and poorly responsive to therapy with antihistaminic agents. Hyperthyroidism was confirmed biochemically, and treatment with methimazole was started. As hyperthyroidism improved, a marked improvement in her urticaria was also observed. However, the patient continued to complain of amenorrhea. Endocrine evaluation, at the age 38, was consistent with premature ovarian failure. This is the first report of coexistence of GD, CSU, and POF. The genetic background of such unusual association is a specific combination of HLA.info:eu-repo/semantics/openAccessSociedade Brasileira de Endocrinologia e MetabologiaArquivos Brasileiros de Endocrinologia & Metabologia v.57 n.9 20132013-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302013000900013en10.1590/S0004-27302013000900013 |
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Ruggeri,Rosaria Maddalena Vita,Giuseppe D'Angelo,Anna Grazia Quattrocchi,Paolina Certo,Rosaria Benvenga,Salvatore Cannavò,Salvatore Gangemi,Sebastiano |
spellingShingle |
Ruggeri,Rosaria Maddalena Vita,Giuseppe D'Angelo,Anna Grazia Quattrocchi,Paolina Certo,Rosaria Benvenga,Salvatore Cannavò,Salvatore Gangemi,Sebastiano The unusual association of Graves' disease, chronic spontaneous urticaria, and premature ovarian failure: report of a case and HLA haplotype characterization |
author_facet |
Ruggeri,Rosaria Maddalena Vita,Giuseppe D'Angelo,Anna Grazia Quattrocchi,Paolina Certo,Rosaria Benvenga,Salvatore Cannavò,Salvatore Gangemi,Sebastiano |
author_sort |
Ruggeri,Rosaria Maddalena |
title |
The unusual association of Graves' disease, chronic spontaneous urticaria, and premature ovarian failure: report of a case and HLA haplotype characterization |
title_short |
The unusual association of Graves' disease, chronic spontaneous urticaria, and premature ovarian failure: report of a case and HLA haplotype characterization |
title_full |
The unusual association of Graves' disease, chronic spontaneous urticaria, and premature ovarian failure: report of a case and HLA haplotype characterization |
title_fullStr |
The unusual association of Graves' disease, chronic spontaneous urticaria, and premature ovarian failure: report of a case and HLA haplotype characterization |
title_full_unstemmed |
The unusual association of Graves' disease, chronic spontaneous urticaria, and premature ovarian failure: report of a case and HLA haplotype characterization |
title_sort |
unusual association of graves' disease, chronic spontaneous urticaria, and premature ovarian failure: report of a case and hla haplotype characterization |
description |
Chronic spontaneous urticaria (CSU), defined as the occurrence of spontaneous wheals for more than six weeks, has been associated with autoimmune diseases. Herein, we report the unusual association of CSU, Graves' disease, and premature ovarian failure. Human leukocyte antigen (HLA) studies were performed. A 36-year-old woman presented symptoms and signs of hyperthyroidism for three months. In the same period, the patient complained of widespread urticarial wheals, intensely itchy, and poorly responsive to therapy with antihistaminic agents. Hyperthyroidism was confirmed biochemically, and treatment with methimazole was started. As hyperthyroidism improved, a marked improvement in her urticaria was also observed. However, the patient continued to complain of amenorrhea. Endocrine evaluation, at the age 38, was consistent with premature ovarian failure. This is the first report of coexistence of GD, CSU, and POF. The genetic background of such unusual association is a specific combination of HLA. |
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Sociedade Brasileira de Endocrinologia e Metabologia |
publishDate |
2013 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302013000900013 |
work_keys_str_mv |
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