Impact of subclinical hypothyroidism treatment in systolic and diastolic cardiac function
OBJECTIVE: To evaluate the effects of levothyroxine (L-T4) replacement in echocardiographic parameters of middle-aged women with subclinical hypothyroidism (SH). SUBJECTS AND METHODS: This was a randomized, double-blind, placebo-controlled study. Echocardiographic evaluation was carried out at baseline and one year after restoration of euthyroidism. Thirty-three women with SH were assigned to one of two groups (L-T4 or placebo). RESULTS: The two groups had similar basal characteristics. There was a significant deterioration of left ventricular Tei index after one year of placebo use, which differed from the effect of L-T4 replacement (+0.086 ± 0.092 vs. -0.014 ± 0.012; p = 0.047). There was also a slight reduction in cardiac output and cardiac index with placebo use, which was not different from L-T4 effect. CONCLUSION: Results suggest a positive impact of L-T4 replacement in cardiac function of middle-aged women with SH.
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Sociedade Brasileira de Endocrinologia e Metabologia
2011
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oai:scielo:S0004-273020110007000052011-11-28Impact of subclinical hypothyroidism treatment in systolic and diastolic cardiac functionMartins,Ricardo MendesFonseca,Regina Helena AlvesDuarte,Marta Maria TuranoReuters,Vaneska SpinelliFerreira,Márcia MartinsAlmeida,CloyraBuescu,AlexandruTeixeira,Patrícia de Fátima dos SantosVaisman,Mario Hypothyroidism thyroxine echocardiography Doppler cardiovascular disease OBJECTIVE: To evaluate the effects of levothyroxine (L-T4) replacement in echocardiographic parameters of middle-aged women with subclinical hypothyroidism (SH). SUBJECTS AND METHODS: This was a randomized, double-blind, placebo-controlled study. Echocardiographic evaluation was carried out at baseline and one year after restoration of euthyroidism. Thirty-three women with SH were assigned to one of two groups (L-T4 or placebo). RESULTS: The two groups had similar basal characteristics. There was a significant deterioration of left ventricular Tei index after one year of placebo use, which differed from the effect of L-T4 replacement (+0.086 ± 0.092 vs. -0.014 ± 0.012; p = 0.047). There was also a slight reduction in cardiac output and cardiac index with placebo use, which was not different from L-T4 effect. CONCLUSION: Results suggest a positive impact of L-T4 replacement in cardiac function of middle-aged women with SH.info:eu-repo/semantics/openAccessSociedade Brasileira de Endocrinologia e MetabologiaArquivos Brasileiros de Endocrinologia & Metabologia v.55 n.7 20112011-10-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000700005en10.1590/S0004-27302011000700005 |
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Martins,Ricardo Mendes Fonseca,Regina Helena Alves Duarte,Marta Maria Turano Reuters,Vaneska Spinelli Ferreira,Márcia Martins Almeida,Cloyra Buescu,Alexandru Teixeira,Patrícia de Fátima dos Santos Vaisman,Mario |
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Martins,Ricardo Mendes Fonseca,Regina Helena Alves Duarte,Marta Maria Turano Reuters,Vaneska Spinelli Ferreira,Márcia Martins Almeida,Cloyra Buescu,Alexandru Teixeira,Patrícia de Fátima dos Santos Vaisman,Mario Impact of subclinical hypothyroidism treatment in systolic and diastolic cardiac function |
author_facet |
Martins,Ricardo Mendes Fonseca,Regina Helena Alves Duarte,Marta Maria Turano Reuters,Vaneska Spinelli Ferreira,Márcia Martins Almeida,Cloyra Buescu,Alexandru Teixeira,Patrícia de Fátima dos Santos Vaisman,Mario |
author_sort |
Martins,Ricardo Mendes |
title |
Impact of subclinical hypothyroidism treatment in systolic and diastolic cardiac function |
title_short |
Impact of subclinical hypothyroidism treatment in systolic and diastolic cardiac function |
title_full |
Impact of subclinical hypothyroidism treatment in systolic and diastolic cardiac function |
title_fullStr |
Impact of subclinical hypothyroidism treatment in systolic and diastolic cardiac function |
title_full_unstemmed |
Impact of subclinical hypothyroidism treatment in systolic and diastolic cardiac function |
title_sort |
impact of subclinical hypothyroidism treatment in systolic and diastolic cardiac function |
description |
OBJECTIVE: To evaluate the effects of levothyroxine (L-T4) replacement in echocardiographic parameters of middle-aged women with subclinical hypothyroidism (SH). SUBJECTS AND METHODS: This was a randomized, double-blind, placebo-controlled study. Echocardiographic evaluation was carried out at baseline and one year after restoration of euthyroidism. Thirty-three women with SH were assigned to one of two groups (L-T4 or placebo). RESULTS: The two groups had similar basal characteristics. There was a significant deterioration of left ventricular Tei index after one year of placebo use, which differed from the effect of L-T4 replacement (+0.086 ± 0.092 vs. -0.014 ± 0.012; p = 0.047). There was also a slight reduction in cardiac output and cardiac index with placebo use, which was not different from L-T4 effect. CONCLUSION: Results suggest a positive impact of L-T4 replacement in cardiac function of middle-aged women with SH. |
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Sociedade Brasileira de Endocrinologia e Metabologia |
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2011 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000700005 |
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