The brazilian version of the Quality of Life Assessment of Growth Hormone Deficiency in Adults (QoL-AGHDA): Four-stage translation and validation

OBJECTIVE: This study reports on the Brazilian Portuguese adaptation of the QoL-AGHDA (Quality of Life Assessment of Growth Hormone Deficiency in Adults) for use in adult growth hormone deficient (GHD) patients. MATERIALS AND METHODS: The translation process adopted the dual panel methodology. The questionnaire was tested through field-test interviews (16 GHD patients). In the final stage, data from 120 GHD patients (81 included in a test-retest analysis) were analyzed for internal consistency, test-retest reliability, convergent validity and validity among known groups. RESULTS: The translation panels were successful and the draft version was amended to improve the wording as a result of the field-test interviews. Cronbach's alpha was 0.90 and test-retest reliability 0.88. QoL-AGHDA scores had the expected pattern of association with NHP scale scores and QoL-AGHDA was able to differentiate significantly between patients based on patient-reported general health (p < 0.01) and QoL (p < 0.01). CONCLUSIONS: The adaptation of the QoL-AGHDA for a Brazilian population was successful and the adapted questionnaire was shown to be reliable and valid.

Bibliographic Details

Main Authors:	Ribeiro-Oliveira Jr,Antônio, Mol,Suélem Simão, Twiss,James, Alencar,Guilherme Asmar, Miranda,Paulo Augusto Carvalho, Naves,Luciana A., Azevedo,Monalisa F., Basílio,Flávia M. A., Boguszewski,César Luiz, Nogueira,Kátia C., Vilar,Lúcio, Koltowska-Haggstrom,Maria, McKenna,Steve P.
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Endocrinologia e Metabologia 2010
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000900010
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