Boron neutron capture therapy in cancer: past, present and future
Undifferentiated thyroid cancer (UTC) is a very aggressive tumor with no effective treatment, since it lacks iodine uptake and does not respond to radio or chemotherapy. The prognosis of these patients is bad, due to the rapid growth of the tumor and the early development of metastasis. Boron neutron capture therapy (BNCT) is based on the selective uptake of certain boron non-radioactive compounds by a tumor, and the subsequent irradiation of the area with an appropriate neutron beam. 10B is then activated to 11B, which will immediately decay releasing alpha particles and 7Li, of high linear energy transfer (LET) and limited reach. Clinical trials are being performed in patients with glioblastoma multiforme and melanoma. We have explored its possible application to UTC. Our results demonstrated that a cell line of human UTC has a selective uptake of borophenylalanine (BPA) both in vitro and after transplantation to nude mice. Treatment of mice by BNCT led to a complete control of growth and cure of 100% of the animals. Moreover dogs with spontaneous UTC also have a selective uptake of BPA. At the present we are studying the biodistribution of BPA in patients with UTC before its application in humans.
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Sociedade Brasileira de Endocrinologia e Metabologia
2007
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oai:scielo:S0004-273020070005000242007-09-14Boron neutron capture therapy in cancer: past, present and futurePisarev,Mario A.Dagrosa,Maria AlejandraJuvenal,Guilermo J. Thyroid Cancer Treatment Boron Neutrons Undifferentiated thyroid cancer (UTC) is a very aggressive tumor with no effective treatment, since it lacks iodine uptake and does not respond to radio or chemotherapy. The prognosis of these patients is bad, due to the rapid growth of the tumor and the early development of metastasis. Boron neutron capture therapy (BNCT) is based on the selective uptake of certain boron non-radioactive compounds by a tumor, and the subsequent irradiation of the area with an appropriate neutron beam. 10B is then activated to 11B, which will immediately decay releasing alpha particles and 7Li, of high linear energy transfer (LET) and limited reach. Clinical trials are being performed in patients with glioblastoma multiforme and melanoma. We have explored its possible application to UTC. Our results demonstrated that a cell line of human UTC has a selective uptake of borophenylalanine (BPA) both in vitro and after transplantation to nude mice. Treatment of mice by BNCT led to a complete control of growth and cure of 100% of the animals. Moreover dogs with spontaneous UTC also have a selective uptake of BPA. At the present we are studying the biodistribution of BPA in patients with UTC before its application in humans.info:eu-repo/semantics/openAccessSociedade Brasileira de Endocrinologia e MetabologiaArquivos Brasileiros de Endocrinologia & Metabologia v.51 n.5 20072007-07-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302007000500024en10.1590/S0004-27302007000500024 |
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Pisarev,Mario A. Dagrosa,Maria Alejandra Juvenal,Guilermo J. |
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Pisarev,Mario A. Dagrosa,Maria Alejandra Juvenal,Guilermo J. Boron neutron capture therapy in cancer: past, present and future |
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Pisarev,Mario A. Dagrosa,Maria Alejandra Juvenal,Guilermo J. |
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Pisarev,Mario A. |
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Boron neutron capture therapy in cancer: past, present and future |
title_short |
Boron neutron capture therapy in cancer: past, present and future |
title_full |
Boron neutron capture therapy in cancer: past, present and future |
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Boron neutron capture therapy in cancer: past, present and future |
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Boron neutron capture therapy in cancer: past, present and future |
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boron neutron capture therapy in cancer: past, present and future |
description |
Undifferentiated thyroid cancer (UTC) is a very aggressive tumor with no effective treatment, since it lacks iodine uptake and does not respond to radio or chemotherapy. The prognosis of these patients is bad, due to the rapid growth of the tumor and the early development of metastasis. Boron neutron capture therapy (BNCT) is based on the selective uptake of certain boron non-radioactive compounds by a tumor, and the subsequent irradiation of the area with an appropriate neutron beam. 10B is then activated to 11B, which will immediately decay releasing alpha particles and 7Li, of high linear energy transfer (LET) and limited reach. Clinical trials are being performed in patients with glioblastoma multiforme and melanoma. We have explored its possible application to UTC. Our results demonstrated that a cell line of human UTC has a selective uptake of borophenylalanine (BPA) both in vitro and after transplantation to nude mice. Treatment of mice by BNCT led to a complete control of growth and cure of 100% of the animals. Moreover dogs with spontaneous UTC also have a selective uptake of BPA. At the present we are studying the biodistribution of BPA in patients with UTC before its application in humans. |
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Sociedade Brasileira de Endocrinologia e Metabologia |
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2007 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302007000500024 |
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AT pisarevmarioa boronneutroncapturetherapyincancerpastpresentandfuture AT dagrosamariaalejandra boronneutroncapturetherapyincancerpastpresentandfuture AT juvenalguilermoj boronneutroncapturetherapyincancerpastpresentandfuture |
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