Comparison of safety and efficacy of convalescent plasma with fresh frozen plasma in severe covid-19 patients
Abstract background: Role of Convalescent plasma (COPLA) to treat severe COVID-19 is under investigation. We compared efficacy and safety of COPLA with fresh frozen plasma (FFP) in severe COVID-19 patients. Methods: One group received COPLA with standard medical care (n = 14), and another group received random donor FFP, as control with standard medical care (n = 15) in severe COVID-19 disease. Results: The proportion of patients free of ventilation at day seven were 78.5% in COPLA group, and 93.3 % in control group were not significant (p= 0.258). However, improved respiratory rate, O2 saturation, SOFA score, and Ct value were observed in the COPLA group. No serious adverse events were noticed by plasma transfusion in both groups.
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Academia Brasileira de Ciências
2022
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oai:scielo:S0001-376520220006007012022-10-13Comparison of safety and efficacy of convalescent plasma with fresh frozen plasma in severe covid-19 patientsBAJPAI,MEENUMAHESHWARI,ASHISHKUMAR,SURESHCHHABRA,KARANKALE,PRATIBHANARAYANAN,ASHADGUPTA,AMITAGUPTA,EKTATREHANPATI,NIRUPAMAAGARWAL,RESHUGUPTA,KAMINIBHARDWAJ,ANKITISLAM,MOJAHIDULSINGH,RAVINDERYADAV,PUSHPAKUMAR,GURESHSARIN,SHIV K. COVID-19 convalescent plasma donor plasmapheresis ARDS immunoglobulins antibodies Abstract background: Role of Convalescent plasma (COPLA) to treat severe COVID-19 is under investigation. We compared efficacy and safety of COPLA with fresh frozen plasma (FFP) in severe COVID-19 patients. Methods: One group received COPLA with standard medical care (n = 14), and another group received random donor FFP, as control with standard medical care (n = 15) in severe COVID-19 disease. Results: The proportion of patients free of ventilation at day seven were 78.5% in COPLA group, and 93.3 % in control group were not significant (p= 0.258). However, improved respiratory rate, O2 saturation, SOFA score, and Ct value were observed in the COPLA group. No serious adverse events were noticed by plasma transfusion in both groups.info:eu-repo/semantics/openAccessAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências v.94 n.4 20222022-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000600701en10.1590/0001-3765202220210202 |
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BAJPAI,MEENU MAHESHWARI,ASHISH KUMAR,SURESH CHHABRA,KARAN KALE,PRATIBHA NARAYANAN,ASHAD GUPTA,AMITA GUPTA,EKTA TREHANPATI,NIRUPAMA AGARWAL,RESHU GUPTA,KAMINI BHARDWAJ,ANKIT ISLAM,MOJAHIDUL SINGH,RAVINDER YADAV,PUSHPA KUMAR,GURESH SARIN,SHIV K. |
| spellingShingle |
BAJPAI,MEENU MAHESHWARI,ASHISH KUMAR,SURESH CHHABRA,KARAN KALE,PRATIBHA NARAYANAN,ASHAD GUPTA,AMITA GUPTA,EKTA TREHANPATI,NIRUPAMA AGARWAL,RESHU GUPTA,KAMINI BHARDWAJ,ANKIT ISLAM,MOJAHIDUL SINGH,RAVINDER YADAV,PUSHPA KUMAR,GURESH SARIN,SHIV K. Comparison of safety and efficacy of convalescent plasma with fresh frozen plasma in severe covid-19 patients |
| author_facet |
BAJPAI,MEENU MAHESHWARI,ASHISH KUMAR,SURESH CHHABRA,KARAN KALE,PRATIBHA NARAYANAN,ASHAD GUPTA,AMITA GUPTA,EKTA TREHANPATI,NIRUPAMA AGARWAL,RESHU GUPTA,KAMINI BHARDWAJ,ANKIT ISLAM,MOJAHIDUL SINGH,RAVINDER YADAV,PUSHPA KUMAR,GURESH SARIN,SHIV K. |
| author_sort |
BAJPAI,MEENU |
| title |
Comparison of safety and efficacy of convalescent plasma with fresh frozen plasma in severe covid-19 patients |
| title_short |
Comparison of safety and efficacy of convalescent plasma with fresh frozen plasma in severe covid-19 patients |
| title_full |
Comparison of safety and efficacy of convalescent plasma with fresh frozen plasma in severe covid-19 patients |
| title_fullStr |
Comparison of safety and efficacy of convalescent plasma with fresh frozen plasma in severe covid-19 patients |
| title_full_unstemmed |
Comparison of safety and efficacy of convalescent plasma with fresh frozen plasma in severe covid-19 patients |
| title_sort |
comparison of safety and efficacy of convalescent plasma with fresh frozen plasma in severe covid-19 patients |
| description |
Abstract background: Role of Convalescent plasma (COPLA) to treat severe COVID-19 is under investigation. We compared efficacy and safety of COPLA with fresh frozen plasma (FFP) in severe COVID-19 patients. Methods: One group received COPLA with standard medical care (n = 14), and another group received random donor FFP, as control with standard medical care (n = 15) in severe COVID-19 disease. Results: The proportion of patients free of ventilation at day seven were 78.5% in COPLA group, and 93.3 % in control group were not significant (p= 0.258). However, improved respiratory rate, O2 saturation, SOFA score, and Ct value were observed in the COPLA group. No serious adverse events were noticed by plasma transfusion in both groups. |
| publisher |
Academia Brasileira de Ciências |
| publishDate |
2022 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000600701 |
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