Tissue reaction and anti-biofilm action of new biomaterial composed of latex from Hancornia speciosa Gomes and silver nanoparticles
Abstract In this work, the natural latex extracted from Harconia speciosa was incorporated with silver nanoparticles (AgNP) to compose a functional biomaterial associating the intrinsic angiogenic activity of the latex and the antimicrobial activity of AgNP. Tissue reaction after subcutaneous implantation in dorsum of rats of membranes without AgNP and with 0.05%, 0.4% AgNP was compared at 3, 7 and 25 days. No statistically significant difference in the tissue response of the different biomaterials was observed, indicating that AgNP did not interfere with the inflammatory reaction (p > 0.05) or with the angiogenic activity of latex. Biomembranes were also tested against bacterial biofilm formation by Staphylococcus aureus and the antimicrobial activity of the new biomaterial can be found with bacteria crenation (0.05% AgNP) and no biofilm deposition (0.4% AgNP). Therefore, this biomaterial has interesting properties for the tissue repair process and may be feasible for future applications as dressing.
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2020
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oai:scielo:S0001-376520200007009092020-11-12Tissue reaction and anti-biofilm action of new biomaterial composed of latex from Hancornia speciosa Gomes and silver nanoparticlesBONETE,JÉSSICA M.SILVA,GUILHERME D.GUIDELLI,ÉDER J.GONÇALVES,PABLO J.ALMEIDA,LUCIANE M.BAFFA,OSWALDOKINOSHITA,ANGELA antimicrobial activity biomembrane biocompatibility inflammation silver nanoparticle wound dressings Abstract In this work, the natural latex extracted from Harconia speciosa was incorporated with silver nanoparticles (AgNP) to compose a functional biomaterial associating the intrinsic angiogenic activity of the latex and the antimicrobial activity of AgNP. Tissue reaction after subcutaneous implantation in dorsum of rats of membranes without AgNP and with 0.05%, 0.4% AgNP was compared at 3, 7 and 25 days. No statistically significant difference in the tissue response of the different biomaterials was observed, indicating that AgNP did not interfere with the inflammatory reaction (p > 0.05) or with the angiogenic activity of latex. Biomembranes were also tested against bacterial biofilm formation by Staphylococcus aureus and the antimicrobial activity of the new biomaterial can be found with bacteria crenation (0.05% AgNP) and no biofilm deposition (0.4% AgNP). Therefore, this biomaterial has interesting properties for the tissue repair process and may be feasible for future applications as dressing.info:eu-repo/semantics/openAccessAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências v.92 n.4 20202020-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000700909en10.1590/0001-3765202020191584 |
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BONETE,JÉSSICA M. SILVA,GUILHERME D. GUIDELLI,ÉDER J. GONÇALVES,PABLO J. ALMEIDA,LUCIANE M. BAFFA,OSWALDO KINOSHITA,ANGELA |
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BONETE,JÉSSICA M. SILVA,GUILHERME D. GUIDELLI,ÉDER J. GONÇALVES,PABLO J. ALMEIDA,LUCIANE M. BAFFA,OSWALDO KINOSHITA,ANGELA Tissue reaction and anti-biofilm action of new biomaterial composed of latex from Hancornia speciosa Gomes and silver nanoparticles |
author_facet |
BONETE,JÉSSICA M. SILVA,GUILHERME D. GUIDELLI,ÉDER J. GONÇALVES,PABLO J. ALMEIDA,LUCIANE M. BAFFA,OSWALDO KINOSHITA,ANGELA |
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BONETE,JÉSSICA M. |
title |
Tissue reaction and anti-biofilm action of new biomaterial composed of latex from Hancornia speciosa Gomes and silver nanoparticles |
title_short |
Tissue reaction and anti-biofilm action of new biomaterial composed of latex from Hancornia speciosa Gomes and silver nanoparticles |
title_full |
Tissue reaction and anti-biofilm action of new biomaterial composed of latex from Hancornia speciosa Gomes and silver nanoparticles |
title_fullStr |
Tissue reaction and anti-biofilm action of new biomaterial composed of latex from Hancornia speciosa Gomes and silver nanoparticles |
title_full_unstemmed |
Tissue reaction and anti-biofilm action of new biomaterial composed of latex from Hancornia speciosa Gomes and silver nanoparticles |
title_sort |
tissue reaction and anti-biofilm action of new biomaterial composed of latex from hancornia speciosa gomes and silver nanoparticles |
description |
Abstract In this work, the natural latex extracted from Harconia speciosa was incorporated with silver nanoparticles (AgNP) to compose a functional biomaterial associating the intrinsic angiogenic activity of the latex and the antimicrobial activity of AgNP. Tissue reaction after subcutaneous implantation in dorsum of rats of membranes without AgNP and with 0.05%, 0.4% AgNP was compared at 3, 7 and 25 days. No statistically significant difference in the tissue response of the different biomaterials was observed, indicating that AgNP did not interfere with the inflammatory reaction (p > 0.05) or with the angiogenic activity of latex. Biomembranes were also tested against bacterial biofilm formation by Staphylococcus aureus and the antimicrobial activity of the new biomaterial can be found with bacteria crenation (0.05% AgNP) and no biofilm deposition (0.4% AgNP). Therefore, this biomaterial has interesting properties for the tissue repair process and may be feasible for future applications as dressing. |
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Academia Brasileira de Ciências |
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2020 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000700909 |
work_keys_str_mv |
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