A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats

A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats

Abstract: The aim of this study was investigate the effects of a low-protein, high-carbohydrate (LPHC) diet introduced to rats soon after weaning. The animals were distributed in the following groups: LPHC45: fed an LPHC diet (6%-protein, 74%-carbohydrate) for 45 days; C45: fed a control (C) diet (17%-protein, 63%-carbohydrate) for 45 days; R (Reverse): fed with LPHC for 15 days followed by C diet for 30 days. The LPHC45 group showed alterations in the energetic balance with an increase in brown adipose tissue, and in glucose tolerance, and lower final body weight, muscle mass and total protein in blood when compared with C45 group. The HOMA-IR index was similar between LPHC45 and C45 groups, but this parameter was lower in LPHC45 compared with R groups. Serum adiponectin was higher in LPHC45 group than C45 and R groups. The R group presented higher fed insulin than C45 and LPHC45 and higher T4 compared with C45 group. Total cholesterol in R group was higher when compared with LPHC45 group. Thus, the data show that the change of the diet LPHC for a balanced diet led to different metabolic evolution and suggest that the different response can be due to different levels of adiponectin.

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Main Authors: CEOLIN,PATRÍCIA, FRANÇA,SUÉLEM A. DE, FROELICH,MENDALLI, SANTOS,MAÍSA P. DOS, PEREIRA,MAYARA P., QUEIROZ,THAÍS S., SILVA,FLÁVIA H.S. DA, LISBOA,PATRÍCIA C., ANDRADE,CLAUDIA M.B., BAVIERA,AMANDA M., KAWASHITA,NAIR H.
Format: Digital revista
Language:English
Published: Academia Brasileira de Ciências 2019
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300714
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spelling oai:scielo:S0001-376520190003007142019-06-27A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in ratsCEOLIN,PATRÍCIAFRANÇA,SUÉLEM A. DEFROELICH,MENDALLISANTOS,MAÍSA P. DOSPEREIRA,MAYARA P.QUEIROZ,THAÍS S.SILVA,FLÁVIA H.S. DALISBOA,PATRÍCIA C.ANDRADE,CLAUDIA M.B.BAVIERA,AMANDA M.KAWASHITA,NAIR H. low-protein high-carbohydrate diet post-weaning period HOMA-IR adiponectin Abstract: The aim of this study was investigate the effects of a low-protein, high-carbohydrate (LPHC) diet introduced to rats soon after weaning. The animals were distributed in the following groups: LPHC45: fed an LPHC diet (6%-protein, 74%-carbohydrate) for 45 days; C45: fed a control (C) diet (17%-protein, 63%-carbohydrate) for 45 days; R (Reverse): fed with LPHC for 15 days followed by C diet for 30 days. The LPHC45 group showed alterations in the energetic balance with an increase in brown adipose tissue, and in glucose tolerance, and lower final body weight, muscle mass and total protein in blood when compared with C45 group. The HOMA-IR index was similar between LPHC45 and C45 groups, but this parameter was lower in LPHC45 compared with R groups. Serum adiponectin was higher in LPHC45 group than C45 and R groups. The R group presented higher fed insulin than C45 and LPHC45 and higher T4 compared with C45 group. Total cholesterol in R group was higher when compared with LPHC45 group. Thus, the data show that the change of the diet LPHC for a balanced diet led to different metabolic evolution and suggest that the different response can be due to different levels of adiponectin.info:eu-repo/semantics/openAccessAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências v.91 n.2 20192019-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300714en10.1590/0001-3765201920180452
institution SCIELO
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language English
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author CEOLIN,PATRÍCIA
FRANÇA,SUÉLEM A. DE
FROELICH,MENDALLI
SANTOS,MAÍSA P. DOS
PEREIRA,MAYARA P.
QUEIROZ,THAÍS S.
SILVA,FLÁVIA H.S. DA
LISBOA,PATRÍCIA C.
ANDRADE,CLAUDIA M.B.
BAVIERA,AMANDA M.
KAWASHITA,NAIR H.
spellingShingle CEOLIN,PATRÍCIA
FRANÇA,SUÉLEM A. DE
FROELICH,MENDALLI
SANTOS,MAÍSA P. DOS
PEREIRA,MAYARA P.
QUEIROZ,THAÍS S.
SILVA,FLÁVIA H.S. DA
LISBOA,PATRÍCIA C.
ANDRADE,CLAUDIA M.B.
BAVIERA,AMANDA M.
KAWASHITA,NAIR H.
A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats
author_facet CEOLIN,PATRÍCIA
FRANÇA,SUÉLEM A. DE
FROELICH,MENDALLI
SANTOS,MAÍSA P. DOS
PEREIRA,MAYARA P.
QUEIROZ,THAÍS S.
SILVA,FLÁVIA H.S. DA
LISBOA,PATRÍCIA C.
ANDRADE,CLAUDIA M.B.
BAVIERA,AMANDA M.
KAWASHITA,NAIR H.
author_sort CEOLIN,PATRÍCIA
title A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats
title_short A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats
title_full A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats
title_fullStr A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats
title_full_unstemmed A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats
title_sort low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats
description Abstract: The aim of this study was investigate the effects of a low-protein, high-carbohydrate (LPHC) diet introduced to rats soon after weaning. The animals were distributed in the following groups: LPHC45: fed an LPHC diet (6%-protein, 74%-carbohydrate) for 45 days; C45: fed a control (C) diet (17%-protein, 63%-carbohydrate) for 45 days; R (Reverse): fed with LPHC for 15 days followed by C diet for 30 days. The LPHC45 group showed alterations in the energetic balance with an increase in brown adipose tissue, and in glucose tolerance, and lower final body weight, muscle mass and total protein in blood when compared with C45 group. The HOMA-IR index was similar between LPHC45 and C45 groups, but this parameter was lower in LPHC45 compared with R groups. Serum adiponectin was higher in LPHC45 group than C45 and R groups. The R group presented higher fed insulin than C45 and LPHC45 and higher T4 compared with C45 group. Total cholesterol in R group was higher when compared with LPHC45 group. Thus, the data show that the change of the diet LPHC for a balanced diet led to different metabolic evolution and suggest that the different response can be due to different levels of adiponectin.
publisher Academia Brasileira de Ciências
publishDate 2019
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300714
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