Saline extract from Malpighia emarginata DC leaves showed higher polyphenol presence, antioxidant and antifungal activity and promoted cell proliferation in mice splenocytes.

Saline extract from Malpighia emarginata DC leaves showed higher polyphenol presence, antioxidant and antifungal activity and promoted cell proliferation in mice splenocytes.

Abstract: Currently, the research of new natural compounds with biological potential demonstrates great ethnopharmacological importance. In this study, we evaluated the biological properties promoted by saline extract from Malpighia emarginata DC leaves, whose objective is to evaluate the antioxidant, antimicrobial and cytotoxicity potential. Phytochemical characterization was performed by UPLC-MS chromatography to identify the chemical compounds. For the antioxidant potential, DPPH, ATT and FRAP methods were used. The antibacterial and antifungal tests were performed evaluating the MIC50, MIC90, CMB and CMF parameters. Moreover, antibiofilm action was evaluated. Cytotoxicity and proliferation were performed using splenocytes from Balb/c mice and were evaluated by cytometry. We found a list of phenolic compounds among other bioactive compounds in the M. emarginata saline extract. In addition, higher antioxidant profile and antifungal activity against different strains of Candida spp. was promoted by the saline extract. Splenocytes showed greater cell viability (more than 90%) and showed higher proliferate index in 24 and 48 hours of incubation with the extract. Saline extract from Malpighia emarginata DC has potential action like antioxidant and antifungal agent without promote animal cell damage.

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Main Authors: BARROS,BÁRBARA R.S., BARBOZA,BRUNO RAFAEL, RAMOS,BÁRBARA A., MOURA,MAIARA C. DE, COELHO,LUANA C.B.B., NAPOLEÃO,THIAGO HENRIQUE, CORREIA,MARIA TEREZA S., PAIVA,PATRÍCIA MARIA G., CRUZ FILHO,IRANILDO JOSÉ DA, SILVA,TÚLIO DIEGO DA, LIMA,CLÁUDIA S.A., MELO,CRISTIANE M.L. DE
Format: Digital revista
Language:English
Published: Academia Brasileira de Ciências 2019
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100627
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spelling oai:scielo:S0001-376520190001006272019-04-16Saline extract from Malpighia emarginata DC leaves showed higher polyphenol presence, antioxidant and antifungal activity and promoted cell proliferation in mice splenocytes.BARROS,BÁRBARA R.S.BARBOZA,BRUNO RAFAELRAMOS,BÁRBARA A.MOURA,MAIARA C. DECOELHO,LUANA C.B.B.NAPOLEÃO,THIAGO HENRIQUECORREIA,MARIA TEREZA S.PAIVA,PATRÍCIA MARIA G.CRUZ FILHO,IRANILDO JOSÉ DASILVA,TÚLIO DIEGO DALIMA,CLÁUDIA S.A.MELO,CRISTIANE M.L. DE bioactive compounds cytotoxicity Malpighia emarginata DC phytochemical Abstract: Currently, the research of new natural compounds with biological potential demonstrates great ethnopharmacological importance. In this study, we evaluated the biological properties promoted by saline extract from Malpighia emarginata DC leaves, whose objective is to evaluate the antioxidant, antimicrobial and cytotoxicity potential. Phytochemical characterization was performed by UPLC-MS chromatography to identify the chemical compounds. For the antioxidant potential, DPPH, ATT and FRAP methods were used. The antibacterial and antifungal tests were performed evaluating the MIC50, MIC90, CMB and CMF parameters. Moreover, antibiofilm action was evaluated. Cytotoxicity and proliferation were performed using splenocytes from Balb/c mice and were evaluated by cytometry. We found a list of phenolic compounds among other bioactive compounds in the M. emarginata saline extract. In addition, higher antioxidant profile and antifungal activity against different strains of Candida spp. was promoted by the saline extract. Splenocytes showed greater cell viability (more than 90%) and showed higher proliferate index in 24 and 48 hours of incubation with the extract. Saline extract from Malpighia emarginata DC has potential action like antioxidant and antifungal agent without promote animal cell damage.info:eu-repo/semantics/openAccessAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências v.91 n.1 20192019-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100627en10.1590/0001-3765201920180358
institution SCIELO
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country Brasil
countrycode BR
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libraryname SciELO
language English
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author BARROS,BÁRBARA R.S.
BARBOZA,BRUNO RAFAEL
RAMOS,BÁRBARA A.
MOURA,MAIARA C. DE
COELHO,LUANA C.B.B.
NAPOLEÃO,THIAGO HENRIQUE
CORREIA,MARIA TEREZA S.
PAIVA,PATRÍCIA MARIA G.
CRUZ FILHO,IRANILDO JOSÉ DA
SILVA,TÚLIO DIEGO DA
LIMA,CLÁUDIA S.A.
MELO,CRISTIANE M.L. DE
spellingShingle BARROS,BÁRBARA R.S.
BARBOZA,BRUNO RAFAEL
RAMOS,BÁRBARA A.
MOURA,MAIARA C. DE
COELHO,LUANA C.B.B.
NAPOLEÃO,THIAGO HENRIQUE
CORREIA,MARIA TEREZA S.
PAIVA,PATRÍCIA MARIA G.
CRUZ FILHO,IRANILDO JOSÉ DA
SILVA,TÚLIO DIEGO DA
LIMA,CLÁUDIA S.A.
MELO,CRISTIANE M.L. DE
Saline extract from Malpighia emarginata DC leaves showed higher polyphenol presence, antioxidant and antifungal activity and promoted cell proliferation in mice splenocytes.
author_facet BARROS,BÁRBARA R.S.
BARBOZA,BRUNO RAFAEL
RAMOS,BÁRBARA A.
MOURA,MAIARA C. DE
COELHO,LUANA C.B.B.
NAPOLEÃO,THIAGO HENRIQUE
CORREIA,MARIA TEREZA S.
PAIVA,PATRÍCIA MARIA G.
CRUZ FILHO,IRANILDO JOSÉ DA
SILVA,TÚLIO DIEGO DA
LIMA,CLÁUDIA S.A.
MELO,CRISTIANE M.L. DE
author_sort BARROS,BÁRBARA R.S.
title Saline extract from Malpighia emarginata DC leaves showed higher polyphenol presence, antioxidant and antifungal activity and promoted cell proliferation in mice splenocytes.
title_short Saline extract from Malpighia emarginata DC leaves showed higher polyphenol presence, antioxidant and antifungal activity and promoted cell proliferation in mice splenocytes.
title_full Saline extract from Malpighia emarginata DC leaves showed higher polyphenol presence, antioxidant and antifungal activity and promoted cell proliferation in mice splenocytes.
title_fullStr Saline extract from Malpighia emarginata DC leaves showed higher polyphenol presence, antioxidant and antifungal activity and promoted cell proliferation in mice splenocytes.
title_full_unstemmed Saline extract from Malpighia emarginata DC leaves showed higher polyphenol presence, antioxidant and antifungal activity and promoted cell proliferation in mice splenocytes.
title_sort saline extract from malpighia emarginata dc leaves showed higher polyphenol presence, antioxidant and antifungal activity and promoted cell proliferation in mice splenocytes.
description Abstract: Currently, the research of new natural compounds with biological potential demonstrates great ethnopharmacological importance. In this study, we evaluated the biological properties promoted by saline extract from Malpighia emarginata DC leaves, whose objective is to evaluate the antioxidant, antimicrobial and cytotoxicity potential. Phytochemical characterization was performed by UPLC-MS chromatography to identify the chemical compounds. For the antioxidant potential, DPPH, ATT and FRAP methods were used. The antibacterial and antifungal tests were performed evaluating the MIC50, MIC90, CMB and CMF parameters. Moreover, antibiofilm action was evaluated. Cytotoxicity and proliferation were performed using splenocytes from Balb/c mice and were evaluated by cytometry. We found a list of phenolic compounds among other bioactive compounds in the M. emarginata saline extract. In addition, higher antioxidant profile and antifungal activity against different strains of Candida spp. was promoted by the saline extract. Splenocytes showed greater cell viability (more than 90%) and showed higher proliferate index in 24 and 48 hours of incubation with the extract. Saline extract from Malpighia emarginata DC has potential action like antioxidant and antifungal agent without promote animal cell damage.
publisher Academia Brasileira de Ciências
publishDate 2019
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100627
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