A brief report on some health aspects of rats fed with crescent levels of recombinant chagasin, a potential plant defense protein
Chagasin may be considered a potential plant-incorporated protectant (PIP) protein due to its deleterious effects on insect pests. However, extensive safety studies with PIP's are necessary before introducing them into the target plant. Thus, a short-term feeding trial in rats with high doses of r-chagasin was conducted to provide evidences about its safety. Three test diets containing casein + r-chagasin (0.25, 0.5 and 1% of total protein) were offered to rats (10 days). The test diets did not show adverse effects upon the development, organ weight, hematological parameters and serum protein profiles of rats, providing preliminary information on the safety of r-chagasin.
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Academia Brasileira de Ciências
2012
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oai:scielo:S0001-376520120001000192012-05-22A brief report on some health aspects of rats fed with crescent levels of recombinant chagasin, a potential plant defense proteinOliveira Neto,Osmundo B.Farias,Davi F.Vasconcelos,Ilka M.Paes,Norma S.Monteiro,Ana C. S.Silva,Maria C. M. daGuimarães,Luciane M.Carvalho,Ana F.U.Grossi-de-Sá,Maria F. chagasin recombinant protein hazard potential short-term rat feeding trial Chagasin may be considered a potential plant-incorporated protectant (PIP) protein due to its deleterious effects on insect pests. However, extensive safety studies with PIP's are necessary before introducing them into the target plant. Thus, a short-term feeding trial in rats with high doses of r-chagasin was conducted to provide evidences about its safety. Three test diets containing casein + r-chagasin (0.25, 0.5 and 1% of total protein) were offered to rats (10 days). The test diets did not show adverse effects upon the development, organ weight, hematological parameters and serum protein profiles of rats, providing preliminary information on the safety of r-chagasin.info:eu-repo/semantics/openAccessAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências v.84 n.1 20122012-03-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000100019en10.1590/S0001-37652012005000005 |
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Oliveira Neto,Osmundo B. Farias,Davi F. Vasconcelos,Ilka M. Paes,Norma S. Monteiro,Ana C. S. Silva,Maria C. M. da Guimarães,Luciane M. Carvalho,Ana F.U. Grossi-de-Sá,Maria F. |
spellingShingle |
Oliveira Neto,Osmundo B. Farias,Davi F. Vasconcelos,Ilka M. Paes,Norma S. Monteiro,Ana C. S. Silva,Maria C. M. da Guimarães,Luciane M. Carvalho,Ana F.U. Grossi-de-Sá,Maria F. A brief report on some health aspects of rats fed with crescent levels of recombinant chagasin, a potential plant defense protein |
author_facet |
Oliveira Neto,Osmundo B. Farias,Davi F. Vasconcelos,Ilka M. Paes,Norma S. Monteiro,Ana C. S. Silva,Maria C. M. da Guimarães,Luciane M. Carvalho,Ana F.U. Grossi-de-Sá,Maria F. |
author_sort |
Oliveira Neto,Osmundo B. |
title |
A brief report on some health aspects of rats fed with crescent levels of recombinant chagasin, a potential plant defense protein |
title_short |
A brief report on some health aspects of rats fed with crescent levels of recombinant chagasin, a potential plant defense protein |
title_full |
A brief report on some health aspects of rats fed with crescent levels of recombinant chagasin, a potential plant defense protein |
title_fullStr |
A brief report on some health aspects of rats fed with crescent levels of recombinant chagasin, a potential plant defense protein |
title_full_unstemmed |
A brief report on some health aspects of rats fed with crescent levels of recombinant chagasin, a potential plant defense protein |
title_sort |
brief report on some health aspects of rats fed with crescent levels of recombinant chagasin, a potential plant defense protein |
description |
Chagasin may be considered a potential plant-incorporated protectant (PIP) protein due to its deleterious effects on insect pests. However, extensive safety studies with PIP's are necessary before introducing them into the target plant. Thus, a short-term feeding trial in rats with high doses of r-chagasin was conducted to provide evidences about its safety. Three test diets containing casein + r-chagasin (0.25, 0.5 and 1% of total protein) were offered to rats (10 days). The test diets did not show adverse effects upon the development, organ weight, hematological parameters and serum protein profiles of rats, providing preliminary information on the safety of r-chagasin. |
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Academia Brasileira de Ciências |
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2012 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000100019 |
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