ESTUDIO ANÁTOMO-HISTOPATOLÓGICO INTESTINAL EN TRATAMIENTO CON METRONIDAZOL EN ENTERITIS AGUDA INDUCIDA POR INDOMETACINA EN RATAS ALBINAS

ESTUDIO ANÁTOMO-HISTOPATOLÓGICO INTESTINAL EN TRATAMIENTO CON METRONIDAZOL EN ENTERITIS AGUDA INDUCIDA POR INDOMETACINA EN RATAS ALBINAS

The anatomo histopathological characteristics of the intestine in rats with acute enteritis induced by injection of one dose of indomethacine and treated with metronizadole were evaluated. Male albino Holtzman rats (n=50) were used. They were 4 months old on average and 250-275 g of body weight. Animals were equally distributed in five groups: Control (Group 1), subcutaneously injected with indomethacine (15 mg/kg) (Group 2), and injected with indomethacine plus 1, 2 or 3 doses of metronizadole (50 mg/kg) (groups 3, 4 and 5, respectively). The first dose of metronizadole was orally administered 50 minutes before the indomethacine and subsequent doses were every 5 hours. The observation of lesions was done 48 hours later. Lesions were located in the mesenteric side of the medium and distal jejune. Macroscopic lesions were characterized by thickness and dilatation of the intestinal wall, loss of the mucosa, hyperemia, and the absence of lineal ulcers longer than 10 cm. No statistical differences were found between groups treated with metronizadole (p>0.05); however, differences between these groups with the indomethacine group (p=0.021) were found. Microscopic lesions were characterized by erosion of the mucosa, presence of fibrin and mienteric plexus degeneration. No differences between the metronizadole treated groups (p>0.05) were found.

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Main Authors: Moscol A., Beatriz, Chavera C., Alfonso, Angulo H, Pedro
Format: Digital revista
Language:spa
Published: Universidad Nacional Mayor de San Marcos, Facultad de Medicina Veterinaria 2005
Online Access:https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/1525
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spelling oai:ojs.csi.unmsm:article-15252020-03-12T21:23:20Z ESTUDIO ANÁTOMO-HISTOPATOLÓGICO INTESTINAL EN TRATAMIENTO CON METRONIDAZOL EN ENTERITIS AGUDA INDUCIDA POR INDOMETACINA EN RATAS ALBINAS ESTUDIO ANÁTOMO-HISTOPATOLÓGICO INTESTINAL EN EL TRATAMIENTO CON METRONIDAZOL EN ENTERITIS AGUDA INDUCIDA POR INDOMETACINA EN RATAS ALBINAS Moscol A., Beatriz Chavera C., Alfonso Angulo H, Pedro Metronizadol indometacina inflamación rata. metronizadole indomethacine inflammation rat The anatomo histopathological characteristics of the intestine in rats with acute enteritis induced by injection of one dose of indomethacine and treated with metronizadole were evaluated. Male albino Holtzman rats (n=50) were used. They were 4 months old on average and 250-275 g of body weight. Animals were equally distributed in five groups: Control (Group 1), subcutaneously injected with indomethacine (15 mg/kg) (Group 2), and injected with indomethacine plus 1, 2 or 3 doses of metronizadole (50 mg/kg) (groups 3, 4 and 5, respectively). The first dose of metronizadole was orally administered 50 minutes before the indomethacine and subsequent doses were every 5 hours. The observation of lesions was done 48 hours later. Lesions were located in the mesenteric side of the medium and distal jejune. Macroscopic lesions were characterized by thickness and dilatation of the intestinal wall, loss of the mucosa, hyperemia, and the absence of lineal ulcers longer than 10 cm. No statistical differences were found between groups treated with metronizadole (p>0.05); however, differences between these groups with the indomethacine group (p=0.021) were found. Microscopic lesions were characterized by erosion of the mucosa, presence of fibrin and mienteric plexus degeneration. No differences between the metronizadole treated groups (p>0.05) were found. Se evaluaron las características anatómicas e histopatológicas del intestino de ratas con enteritis aguda inducida con una dosis de indometacina y tratadas con metronidazol. Se usaron 50 ratas albinas machos de la raza Holtzman, de 4 meses de edad promedio y de 250-275 g de peso vivo. Los animales se distribuyeron por igual en 5 grupos. El Lote 1 fue el lote control, el Lote 2 recibió únicamente la indometacina (15 mg/kg p.v. por vía sucutánea), y los lotes 3, 4 y 5 recibieron la indometacina, además de una, dos y tres dosis de metronizadol (50 mg/kg p.v. por vía oral), respectivamente. La primera dosis de metronizadol se administró 50 minutos previos a la indometacina, y las demás dosis con intervalos de 5 horas. La observación de las lesiones se realizó a las 48 horas. Todas las lesiones fueron halladas en el lado mesentérico del yeyuno medio y distal. Las lesiones macroscópicas se caracterizaron por engrosamiento y dilatación de la pared intestinal, pérdida de la mucosa e hiperemia, sin presencia de úlceras lineales mayores de 10 cm. No se encontraron diferencias en las lesiones macroscópicas entre los grupos tratados con metronizadol (p>0.05) , pero hubo diferencia entre estos con el grupo de indometacina sola (p=0.021). Las lesiones microscópicas se caracterizaron por erosión de mucosa , presencia de fibrina y degeneración del plexo mioénterico. No se encontró diferencia estadística entre los grupos tratados con metronizadol( p>0.05). Universidad Nacional Mayor de San Marcos, Facultad de Medicina Veterinaria 2005-07-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article application/pdf https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/1525 10.15381/rivep.v16i1.1525 Revista de Investigaciones Veterinarias del Perú; Vol. 16 No. 1 (2005); 24-33 Revista de Investigaciones Veterinarias del Perú; Vol. 16 Núm. 1 (2005); 24-33 1682-3419 1609-9117 spa https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/1525/1306 Derechos de autor 2005 Beatriz Moscol A., Alfonso Chavera C., Pedro Angulo H https://creativecommons.org/licenses/by-nc-sa/4.0
institution UNMSM
collection OJS
country Perú
countrycode PE
component Revista
access En linea
databasecode rev-rivep
tag revista
region America del Sur
libraryname Biblioteca de la Facultad de Medicina Veterinaria
language spa
format Digital
author Moscol A., Beatriz
Chavera C., Alfonso
Angulo H, Pedro
spellingShingle Moscol A., Beatriz
Chavera C., Alfonso
Angulo H, Pedro
ESTUDIO ANÁTOMO-HISTOPATOLÓGICO INTESTINAL EN TRATAMIENTO CON METRONIDAZOL EN ENTERITIS AGUDA INDUCIDA POR INDOMETACINA EN RATAS ALBINAS
author_facet Moscol A., Beatriz
Chavera C., Alfonso
Angulo H, Pedro
author_sort Moscol A., Beatriz
title ESTUDIO ANÁTOMO-HISTOPATOLÓGICO INTESTINAL EN TRATAMIENTO CON METRONIDAZOL EN ENTERITIS AGUDA INDUCIDA POR INDOMETACINA EN RATAS ALBINAS
title_short ESTUDIO ANÁTOMO-HISTOPATOLÓGICO INTESTINAL EN TRATAMIENTO CON METRONIDAZOL EN ENTERITIS AGUDA INDUCIDA POR INDOMETACINA EN RATAS ALBINAS
title_full ESTUDIO ANÁTOMO-HISTOPATOLÓGICO INTESTINAL EN TRATAMIENTO CON METRONIDAZOL EN ENTERITIS AGUDA INDUCIDA POR INDOMETACINA EN RATAS ALBINAS
title_fullStr ESTUDIO ANÁTOMO-HISTOPATOLÓGICO INTESTINAL EN TRATAMIENTO CON METRONIDAZOL EN ENTERITIS AGUDA INDUCIDA POR INDOMETACINA EN RATAS ALBINAS
title_full_unstemmed ESTUDIO ANÁTOMO-HISTOPATOLÓGICO INTESTINAL EN TRATAMIENTO CON METRONIDAZOL EN ENTERITIS AGUDA INDUCIDA POR INDOMETACINA EN RATAS ALBINAS
title_sort estudio anátomo-histopatológico intestinal en tratamiento con metronidazol en enteritis aguda inducida por indometacina en ratas albinas
description The anatomo histopathological characteristics of the intestine in rats with acute enteritis induced by injection of one dose of indomethacine and treated with metronizadole were evaluated. Male albino Holtzman rats (n=50) were used. They were 4 months old on average and 250-275 g of body weight. Animals were equally distributed in five groups: Control (Group 1), subcutaneously injected with indomethacine (15 mg/kg) (Group 2), and injected with indomethacine plus 1, 2 or 3 doses of metronizadole (50 mg/kg) (groups 3, 4 and 5, respectively). The first dose of metronizadole was orally administered 50 minutes before the indomethacine and subsequent doses were every 5 hours. The observation of lesions was done 48 hours later. Lesions were located in the mesenteric side of the medium and distal jejune. Macroscopic lesions were characterized by thickness and dilatation of the intestinal wall, loss of the mucosa, hyperemia, and the absence of lineal ulcers longer than 10 cm. No statistical differences were found between groups treated with metronizadole (p>0.05); however, differences between these groups with the indomethacine group (p=0.021) were found. Microscopic lesions were characterized by erosion of the mucosa, presence of fibrin and mienteric plexus degeneration. No differences between the metronizadole treated groups (p>0.05) were found.
publisher Universidad Nacional Mayor de San Marcos, Facultad de Medicina Veterinaria
publishDate 2005
url https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/1525
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