Percent of oxygen saturation of arterial hemoglobin among Bolivian aymara at 3,900-4000 m
ABSTRACT. A range of variation in percent of oxygen saturation of arterial hemoglobin (SaO2) among healthy individuals at a given high altitude indicates differences in physiological hypoxemia despite uniform ambient hypoxic stress. In populations native to the Tibetan plateau, a significant portion of the variance is attributable to additive genetic factors, and there is a major gene influencing SaO2. To determine whether there is genetic variance in other high-altitude populations, we designed a study to test the hypothesis that additive genetic factors contribute to phenotypic variation in SaO2 among Aymara natives of the Andean plateau, a population geographically distant from the Tibetan plateau and with a long, separate history of high-altitude residence. The average SaO2 of 381 Aymara at 3,900–4,000 m was 92 6 0.15% (SEM) with a range of 84–99%. The average was 2.6% higher than the average SaO2 of a sample of Tibetans at 3,800–4,065 m measured with the same techniques. Quantitative genetic analyses of the Aymara sample detected no significant variance attributable to genetic factors. The presence of genetic variance in SaO2 in the Tibetan sample and its absence in the Aymara sample indicate there is potential for natural selection on this trait in the Tibetan but not the Aymara population. Am J Phys Anthropol 108:41–51, 1999.
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American Journal of Physical Anthroplogy
1999
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| Subjects: | HIPOXIA, TIBETANO, ANDINO, HEREDABILIDAD, GENÉTICA CUANTITATIVA, |
| Online Access: | http://repositorio.umsa.bo/xmlui/handle/123456789/9792 |
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oai:localhost:8080:123456789-97922020-09-19T20:58:19Z Percent of oxygen saturation of arterial hemoglobin among Bolivian aymara at 3,900-4000 m Beall, Cynthia M Almasy, Laura A Blangero, John Williams-Blangero, Sarah Brittenham, Gary M Strohl, Kingman P Decker, Michael J Vargas, Enrique Villena, Mercedes Soria, Rudy Alarcón, Ana María Gonzales, Cristina HIPOXIA TIBETANO ANDINO HEREDABILIDAD GENÉTICA CUANTITATIVA ABSTRACT. A range of variation in percent of oxygen saturation of arterial hemoglobin (SaO2) among healthy individuals at a given high altitude indicates differences in physiological hypoxemia despite uniform ambient hypoxic stress. In populations native to the Tibetan plateau, a significant portion of the variance is attributable to additive genetic factors, and there is a major gene influencing SaO2. To determine whether there is genetic variance in other high-altitude populations, we designed a study to test the hypothesis that additive genetic factors contribute to phenotypic variation in SaO2 among Aymara natives of the Andean plateau, a population geographically distant from the Tibetan plateau and with a long, separate history of high-altitude residence. The average SaO2 of 381 Aymara at 3,900–4,000 m was 92 6 0.15% (SEM) with a range of 84–99%. The average was 2.6% higher than the average SaO2 of a sample of Tibetans at 3,800–4,065 m measured with the same techniques. Quantitative genetic analyses of the Aymara sample detected no significant variance attributable to genetic factors. The presence of genetic variance in SaO2 in the Tibetan sample and its absence in the Aymara sample indicate there is potential for natural selection on this trait in the Tibetan but not the Aymara population. Am J Phys Anthropol 108:41–51, 1999. 2017-03-10T13:29:59Z 2017-03-10T13:29:59Z 1999 Animation http://repositorio.umsa.bo/xmlui/handle/123456789/9792 en application/pdf American Journal of Physical Anthroplogy |
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biblioteca |
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| language |
English |
| topic |
HIPOXIA TIBETANO ANDINO HEREDABILIDAD GENÉTICA CUANTITATIVA HIPOXIA TIBETANO ANDINO HEREDABILIDAD GENÉTICA CUANTITATIVA |
| spellingShingle |
HIPOXIA TIBETANO ANDINO HEREDABILIDAD GENÉTICA CUANTITATIVA HIPOXIA TIBETANO ANDINO HEREDABILIDAD GENÉTICA CUANTITATIVA Beall, Cynthia M Almasy, Laura A Blangero, John Williams-Blangero, Sarah Brittenham, Gary M Strohl, Kingman P Decker, Michael J Vargas, Enrique Villena, Mercedes Soria, Rudy Alarcón, Ana María Gonzales, Cristina Percent of oxygen saturation of arterial hemoglobin among Bolivian aymara at 3,900-4000 m |
| description |
ABSTRACT.
A range of variation in percent of oxygen saturation of
arterial hemoglobin (SaO2) among healthy individuals at a given high
altitude indicates differences in physiological hypoxemia despite uniform
ambient hypoxic stress. In populations native to the Tibetan plateau, a
significant portion of the variance is attributable to additive genetic factors,
and there is a major gene influencing SaO2. To determine whether there is
genetic variance in other high-altitude populations, we designed a study to
test the hypothesis that additive genetic factors contribute to phenotypic
variation in SaO2 among Aymara natives of the Andean plateau, a population
geographically distant from the Tibetan plateau and with a long, separate
history of high-altitude residence. The average SaO2 of 381 Aymara at
3,900–4,000 m was 92 6 0.15% (SEM) with a range of 84–99%. The average
was 2.6% higher than the average SaO2 of a sample of Tibetans at 3,800–4,065
m measured with the same techniques. Quantitative genetic analyses of the
Aymara sample detected no significant variance attributable to genetic
factors. The presence of genetic variance in SaO2 in the Tibetan sample and its
absence in the Aymara sample indicate there is potential for natural selection
on this trait in the Tibetan but not the Aymara population. Am J Phys
Anthropol 108:41–51, 1999. |
| format |
Animation |
| topic_facet |
HIPOXIA TIBETANO ANDINO HEREDABILIDAD GENÉTICA CUANTITATIVA |
| author |
Beall, Cynthia M Almasy, Laura A Blangero, John Williams-Blangero, Sarah Brittenham, Gary M Strohl, Kingman P Decker, Michael J Vargas, Enrique Villena, Mercedes Soria, Rudy Alarcón, Ana María Gonzales, Cristina |
| author_facet |
Beall, Cynthia M Almasy, Laura A Blangero, John Williams-Blangero, Sarah Brittenham, Gary M Strohl, Kingman P Decker, Michael J Vargas, Enrique Villena, Mercedes Soria, Rudy Alarcón, Ana María Gonzales, Cristina |
| author_sort |
Beall, Cynthia M |
| title |
Percent of oxygen saturation of arterial hemoglobin among Bolivian aymara at 3,900-4000 m |
| title_short |
Percent of oxygen saturation of arterial hemoglobin among Bolivian aymara at 3,900-4000 m |
| title_full |
Percent of oxygen saturation of arterial hemoglobin among Bolivian aymara at 3,900-4000 m |
| title_fullStr |
Percent of oxygen saturation of arterial hemoglobin among Bolivian aymara at 3,900-4000 m |
| title_full_unstemmed |
Percent of oxygen saturation of arterial hemoglobin among Bolivian aymara at 3,900-4000 m |
| title_sort |
percent of oxygen saturation of arterial hemoglobin among bolivian aymara at 3,900-4000 m |
| publisher |
American Journal of Physical Anthroplogy |
| publishDate |
1999 |
| url |
http://repositorio.umsa.bo/xmlui/handle/123456789/9792 |
| work_keys_str_mv |
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| _version_ |
1766394710134358016 |