Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension
Adverse events in utero may predispose to cardiovascular disease in adulthood. In preeclampsia, the diseased placenta releases circulating vasculotoxic factors that cause maternal endothelial dysfunction. These factors may pass the placental barrier, and leave a persistent vascular imprint that may predispose to a pathological response in later life. Endothelial dysfunction plays a major role in the pathogenesis of hypoxic pulmonary hypertension. We hypothesized that offspring of pre-eclampsia may be predisposed to pulmonary hypertension at high altitude. To test this hypothesis, we measured systolic pulmonary-artery pressure (echocardiography) in 11 young (age, 7 1 years, X SE) healthy Bolivian offspring of preeclampsia, and in 13 sex- and age-matched offspring of normal pregnancies in La Paz (3600 m). The major new finding was that systolic pulmonary-artery pressure was roughly 33 percent higher in offspring of preeclamptic mothers than in control subjects (36 2 vs. 27 1 mmHg, P 0.001). This exaggerated hypoxic pulmonary vasoconstriction was not related to more severe hypoxemia or exaggerated polyglobulia. These findings provide the very first evidence that preeclampsia leaves a persistent and potentially fatal imprint in the pulmonary circulation of the offspring, which predisposes them to exaggerated hypoxic pulmonary hypertension in later life.
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High Altitude Medicine & Biology
2005-02-22
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Subjects: | PREECLAMPSIA, HIPERTENSIÓN PULMONAR HIPOXICA, DESCENDIENTE DE PREECLÁMPTICA, |
Online Access: | http://repositorio.umsa.bo/xmlui/handle/123456789/9765 |
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oai:localhost:8080:123456789-97652020-09-21T15:32:20Z Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension Sartori, Claudio Jayet, Pierre-Yves Thalmann, Sebastien Stuber, Thomas Hutter, Damian Salinas Salmón, Carlos E Cucchia, Celine Rodriguez, Armando Riveros, Loyola Spielvogel, Hilde Allemann, Yves Villena, Mercedes Scherrer, Urs PREECLAMPSIA HIPERTENSIÓN PULMONAR HIPOXICA DESCENDIENTE DE PREECLÁMPTICA Adverse events in utero may predispose to cardiovascular disease in adulthood. In preeclampsia, the diseased placenta releases circulating vasculotoxic factors that cause maternal endothelial dysfunction. These factors may pass the placental barrier, and leave a persistent vascular imprint that may predispose to a pathological response in later life. Endothelial dysfunction plays a major role in the pathogenesis of hypoxic pulmonary hypertension. We hypothesized that offspring of pre-eclampsia may be predisposed to pulmonary hypertension at high altitude. To test this hypothesis, we measured systolic pulmonary-artery pressure (echocardiography) in 11 young (age, 7 1 years, X SE) healthy Bolivian offspring of preeclampsia, and in 13 sex- and age-matched offspring of normal pregnancies in La Paz (3600 m). The major new finding was that systolic pulmonary-artery pressure was roughly 33 percent higher in offspring of preeclamptic mothers than in control subjects (36 2 vs. 27 1 mmHg, P 0.001). This exaggerated hypoxic pulmonary vasoconstriction was not related to more severe hypoxemia or exaggerated polyglobulia. These findings provide the very first evidence that preeclampsia leaves a persistent and potentially fatal imprint in the pulmonary circulation of the offspring, which predisposes them to exaggerated hypoxic pulmonary hypertension in later life. 2017-02-24T14:07:51Z 2017-02-24T14:07:51Z 2005-02-22 Article http://repositorio.umsa.bo/xmlui/handle/123456789/9765 en application/pdf High Altitude Medicine & Biology |
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PREECLAMPSIA HIPERTENSIÓN PULMONAR HIPOXICA DESCENDIENTE DE PREECLÁMPTICA PREECLAMPSIA HIPERTENSIÓN PULMONAR HIPOXICA DESCENDIENTE DE PREECLÁMPTICA |
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PREECLAMPSIA HIPERTENSIÓN PULMONAR HIPOXICA DESCENDIENTE DE PREECLÁMPTICA PREECLAMPSIA HIPERTENSIÓN PULMONAR HIPOXICA DESCENDIENTE DE PREECLÁMPTICA Sartori, Claudio Jayet, Pierre-Yves Thalmann, Sebastien Stuber, Thomas Hutter, Damian Salinas Salmón, Carlos E Cucchia, Celine Rodriguez, Armando Riveros, Loyola Spielvogel, Hilde Allemann, Yves Villena, Mercedes Scherrer, Urs Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension |
description |
Adverse events in utero may predispose to cardiovascular disease in adulthood. In preeclampsia, the diseased placenta releases circulating vasculotoxic factors
that cause maternal endothelial dysfunction. These factors may pass the placental barrier, and leave a persistent vascular imprint that may predispose to a pathological response in later life. Endothelial dysfunction
plays a major role in the pathogenesis of hypoxic pulmonary hypertension. We hypothesized that offspring
of pre-eclampsia may be predisposed to pulmonary hypertension at high altitude. To test this hypothesis, we
measured systolic pulmonary-artery pressure (echocardiography) in 11 young (age, 7 1 years, X SE)
healthy Bolivian offspring of preeclampsia, and in 13
sex- and age-matched offspring of normal pregnancies
in La Paz (3600 m). The major new finding was that systolic pulmonary-artery pressure was roughly 33 percent
higher in offspring of preeclamptic mothers than in control subjects (36 2 vs. 27 1 mmHg, P 0.001). This
exaggerated hypoxic pulmonary vasoconstriction was
not related to more severe hypoxemia or exaggerated
polyglobulia. These findings provide the very first evidence that preeclampsia leaves a persistent and potentially fatal imprint in the pulmonary circulation of the
offspring, which predisposes them to exaggerated hypoxic pulmonary hypertension in later life. |
format |
Article |
topic_facet |
PREECLAMPSIA HIPERTENSIÓN PULMONAR HIPOXICA DESCENDIENTE DE PREECLÁMPTICA |
author |
Sartori, Claudio Jayet, Pierre-Yves Thalmann, Sebastien Stuber, Thomas Hutter, Damian Salinas Salmón, Carlos E Cucchia, Celine Rodriguez, Armando Riveros, Loyola Spielvogel, Hilde Allemann, Yves Villena, Mercedes Scherrer, Urs |
author_facet |
Sartori, Claudio Jayet, Pierre-Yves Thalmann, Sebastien Stuber, Thomas Hutter, Damian Salinas Salmón, Carlos E Cucchia, Celine Rodriguez, Armando Riveros, Loyola Spielvogel, Hilde Allemann, Yves Villena, Mercedes Scherrer, Urs |
author_sort |
Sartori, Claudio |
title |
Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension |
title_short |
Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension |
title_full |
Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension |
title_fullStr |
Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension |
title_full_unstemmed |
Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension |
title_sort |
offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension |
publisher |
High Altitude Medicine & Biology |
publishDate |
2005-02-22 |
url |
http://repositorio.umsa.bo/xmlui/handle/123456789/9765 |
work_keys_str_mv |
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