Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension

Adverse events in utero may predispose to cardiovascular disease in adulthood. In preeclampsia, the diseased placenta releases circulating vasculotoxic factors that cause maternal endothelial dysfunction. These factors may pass the placental barrier, and leave a persistent vascular imprint that may predispose to a pathological response in later life. Endothelial dysfunction plays a major role in the pathogenesis of hypoxic pulmonary hypertension. We hypothesized that offspring of pre-eclampsia may be predisposed to pulmonary hypertension at high altitude. To test this hypothesis, we measured systolic pulmonary-artery pressure (echocardiography) in 11 young (age, 7 1 years, X SE) healthy Bolivian offspring of preeclampsia, and in 13 sex- and age-matched offspring of normal pregnancies in La Paz (3600 m). The major new finding was that systolic pulmonary-artery pressure was roughly 33 percent higher in offspring of preeclamptic mothers than in control subjects (36 2 vs. 27 1 mmHg, P 0.001). This exaggerated hypoxic pulmonary vasoconstriction was not related to more severe hypoxemia or exaggerated polyglobulia. These findings provide the very first evidence that preeclampsia leaves a persistent and potentially fatal imprint in the pulmonary circulation of the offspring, which predisposes them to exaggerated hypoxic pulmonary hypertension in later life.

Saved in:
Bibliographic Details
Main Authors: Sartori, Claudio, Jayet, Pierre-Yves, Thalmann, Sebastien, Stuber, Thomas, Hutter, Damian, Salinas Salmón, Carlos E, Cucchia, Celine, Rodriguez, Armando, Riveros, Loyola, Spielvogel, Hilde, Allemann, Yves, Villena, Mercedes, Scherrer, Urs
Format: Article biblioteca
Language:English
Published: High Altitude Medicine & Biology 2005-02-22
Subjects:PREECLAMPSIA, HIPERTENSIÓN PULMONAR HIPOXICA, DESCENDIENTE DE PREECLÁMPTICA,
Online Access:http://repositorio.umsa.bo/xmlui/handle/123456789/9765
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:localhost:8080:123456789-9765
record_format koha
spelling oai:localhost:8080:123456789-97652020-09-21T15:32:20Z Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension Sartori, Claudio Jayet, Pierre-Yves Thalmann, Sebastien Stuber, Thomas Hutter, Damian Salinas Salmón, Carlos E Cucchia, Celine Rodriguez, Armando Riveros, Loyola Spielvogel, Hilde Allemann, Yves Villena, Mercedes Scherrer, Urs PREECLAMPSIA HIPERTENSIÓN PULMONAR HIPOXICA DESCENDIENTE DE PREECLÁMPTICA Adverse events in utero may predispose to cardiovascular disease in adulthood. In preeclampsia, the diseased placenta releases circulating vasculotoxic factors that cause maternal endothelial dysfunction. These factors may pass the placental barrier, and leave a persistent vascular imprint that may predispose to a pathological response in later life. Endothelial dysfunction plays a major role in the pathogenesis of hypoxic pulmonary hypertension. We hypothesized that offspring of pre-eclampsia may be predisposed to pulmonary hypertension at high altitude. To test this hypothesis, we measured systolic pulmonary-artery pressure (echocardiography) in 11 young (age, 7 1 years, X SE) healthy Bolivian offspring of preeclampsia, and in 13 sex- and age-matched offspring of normal pregnancies in La Paz (3600 m). The major new finding was that systolic pulmonary-artery pressure was roughly 33 percent higher in offspring of preeclamptic mothers than in control subjects (36 2 vs. 27 1 mmHg, P 0.001). This exaggerated hypoxic pulmonary vasoconstriction was not related to more severe hypoxemia or exaggerated polyglobulia. These findings provide the very first evidence that preeclampsia leaves a persistent and potentially fatal imprint in the pulmonary circulation of the offspring, which predisposes them to exaggerated hypoxic pulmonary hypertension in later life. 2017-02-24T14:07:51Z 2017-02-24T14:07:51Z 2005-02-22 Article http://repositorio.umsa.bo/xmlui/handle/123456789/9765 en application/pdf High Altitude Medicine & Biology
institution UMSA BO
collection DSpace
country Bolivia
countrycode BO
component Bibliográfico
access En linea
databasecode dig-umsa-bo
tag biblioteca
region America del Sur
libraryname Sistema de Unidades de Información de UMSA
language English
topic PREECLAMPSIA
HIPERTENSIÓN PULMONAR HIPOXICA
DESCENDIENTE DE PREECLÁMPTICA
PREECLAMPSIA
HIPERTENSIÓN PULMONAR HIPOXICA
DESCENDIENTE DE PREECLÁMPTICA
spellingShingle PREECLAMPSIA
HIPERTENSIÓN PULMONAR HIPOXICA
DESCENDIENTE DE PREECLÁMPTICA
PREECLAMPSIA
HIPERTENSIÓN PULMONAR HIPOXICA
DESCENDIENTE DE PREECLÁMPTICA
Sartori, Claudio
Jayet, Pierre-Yves
Thalmann, Sebastien
Stuber, Thomas
Hutter, Damian
Salinas Salmón, Carlos E
Cucchia, Celine
Rodriguez, Armando
Riveros, Loyola
Spielvogel, Hilde
Allemann, Yves
Villena, Mercedes
Scherrer, Urs
Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension
description Adverse events in utero may predispose to cardiovascular disease in adulthood. In preeclampsia, the diseased placenta releases circulating vasculotoxic factors that cause maternal endothelial dysfunction. These factors may pass the placental barrier, and leave a persistent vascular imprint that may predispose to a pathological response in later life. Endothelial dysfunction plays a major role in the pathogenesis of hypoxic pulmonary hypertension. We hypothesized that offspring of pre-eclampsia may be predisposed to pulmonary hypertension at high altitude. To test this hypothesis, we measured systolic pulmonary-artery pressure (echocardiography) in 11 young (age, 7 1 years, X SE) healthy Bolivian offspring of preeclampsia, and in 13 sex- and age-matched offspring of normal pregnancies in La Paz (3600 m). The major new finding was that systolic pulmonary-artery pressure was roughly 33 percent higher in offspring of preeclamptic mothers than in control subjects (36 2 vs. 27 1 mmHg, P 0.001). This exaggerated hypoxic pulmonary vasoconstriction was not related to more severe hypoxemia or exaggerated polyglobulia. These findings provide the very first evidence that preeclampsia leaves a persistent and potentially fatal imprint in the pulmonary circulation of the offspring, which predisposes them to exaggerated hypoxic pulmonary hypertension in later life.
format Article
topic_facet PREECLAMPSIA
HIPERTENSIÓN PULMONAR HIPOXICA
DESCENDIENTE DE PREECLÁMPTICA
author Sartori, Claudio
Jayet, Pierre-Yves
Thalmann, Sebastien
Stuber, Thomas
Hutter, Damian
Salinas Salmón, Carlos E
Cucchia, Celine
Rodriguez, Armando
Riveros, Loyola
Spielvogel, Hilde
Allemann, Yves
Villena, Mercedes
Scherrer, Urs
author_facet Sartori, Claudio
Jayet, Pierre-Yves
Thalmann, Sebastien
Stuber, Thomas
Hutter, Damian
Salinas Salmón, Carlos E
Cucchia, Celine
Rodriguez, Armando
Riveros, Loyola
Spielvogel, Hilde
Allemann, Yves
Villena, Mercedes
Scherrer, Urs
author_sort Sartori, Claudio
title Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension
title_short Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension
title_full Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension
title_fullStr Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension
title_full_unstemmed Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension
title_sort offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension
publisher High Altitude Medicine & Biology
publishDate 2005-02-22
url http://repositorio.umsa.bo/xmlui/handle/123456789/9765
work_keys_str_mv AT sartoriclaudio offspringofpreeclampticmothersarepredisposedtohypoxicpulmonaryhypertension
AT jayetpierreyves offspringofpreeclampticmothersarepredisposedtohypoxicpulmonaryhypertension
AT thalmannsebastien offspringofpreeclampticmothersarepredisposedtohypoxicpulmonaryhypertension
AT stuberthomas offspringofpreeclampticmothersarepredisposedtohypoxicpulmonaryhypertension
AT hutterdamian offspringofpreeclampticmothersarepredisposedtohypoxicpulmonaryhypertension
AT salinassalmoncarlose offspringofpreeclampticmothersarepredisposedtohypoxicpulmonaryhypertension
AT cucchiaceline offspringofpreeclampticmothersarepredisposedtohypoxicpulmonaryhypertension
AT rodriguezarmando offspringofpreeclampticmothersarepredisposedtohypoxicpulmonaryhypertension
AT riverosloyola offspringofpreeclampticmothersarepredisposedtohypoxicpulmonaryhypertension
AT spielvogelhilde offspringofpreeclampticmothersarepredisposedtohypoxicpulmonaryhypertension
AT allemannyves offspringofpreeclampticmothersarepredisposedtohypoxicpulmonaryhypertension
AT villenamercedes offspringofpreeclampticmothersarepredisposedtohypoxicpulmonaryhypertension
AT scherrerurs offspringofpreeclampticmothersarepredisposedtohypoxicpulmonaryhypertension
_version_ 1766395255413800960