Life-long consequences of postnatal normoxia exposure in rats raised at high altitude
Abstract. We tested the hypothesis that exposure of high-altitude (HA) rats to a period of postnatal normoxia has long-term consequences on the ventilatory and hematological acclimatization in adults. Male and female HA rats (3,600 m, PO2 100 Torr; La Paz, Bolivia) were exposed to normal room air [HA control (HACont)] or enriched oxygen (32% O2; PO2 160 Torr) from 1 day before to 15 days after birth [HA postnatal normoxia (HApNorm)]. Hematocrit and hemoglobin values were assessed at 2, 12, and 32 wk of age. Cardiac and lung morphology were assessed at 12 wk by measuring right ventricular hypertrophy (pulmonary hypertension index) and lung air space-to-tissue ratio (indicative of alveolarization). Respiratory parameters under baseline conditions and in response to 32% O2 for 10 min (relieving the ambient hypoxic stimulus) were measured by whole body plethysmography at 12 wk. Finally, we performed a survival analysis up to 600 days of age. Compared with HACont, HApNorm rats had reduced hematocrit and hemoglobin levels at all ages (both sexes); reduced right ventricular hypertrophy (both sexes); lower air space-to-tissue ratio in the lungs (males only); reduced CO2 production rate, but higher oxygen uptake (males only); and similar respiratory frequency, tidal volume, and minute ventilation. When breathing 32% O2, HApNorm male rats had a stronger decrease of minute ventilation than HACont. HApNorm rats had a marked tendency toward longer survival throughout the study. We conclude that exposure to ambient hypoxia during postnatal development in HA rats has deleterious consequences on acclimatization to hypoxia as adults.
Main Authors: | , , , , , |
---|---|
Format: | Article biblioteca |
Language: | English |
Published: |
J Appl Physiol.
2012
|
Subjects: | DESARROLLO, PULMONES, RESPIRACIÓN, |
Online Access: | http://repositorio.umsa.bo/xmlui/handle/123456789/25261 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:localhost:8080:123456789-25261 |
---|---|
record_format |
koha |
spelling |
oai:localhost:8080:123456789-252612021-05-25T14:12:22Z Life-long consequences of postnatal normoxia exposure in rats raised at high altitude Lumbroso, Delphine Lemoine, Alexandra Gonzales, Marcelino Villalpando, Gabriela Seaborn, Tommy Joseph, Vincent DESARROLLO PULMONES RESPIRACIÓN Abstract. We tested the hypothesis that exposure of high-altitude (HA) rats to a period of postnatal normoxia has long-term consequences on the ventilatory and hematological acclimatization in adults. Male and female HA rats (3,600 m, PO2 100 Torr; La Paz, Bolivia) were exposed to normal room air [HA control (HACont)] or enriched oxygen (32% O2; PO2 160 Torr) from 1 day before to 15 days after birth [HA postnatal normoxia (HApNorm)]. Hematocrit and hemoglobin values were assessed at 2, 12, and 32 wk of age. Cardiac and lung morphology were assessed at 12 wk by measuring right ventricular hypertrophy (pulmonary hypertension index) and lung air space-to-tissue ratio (indicative of alveolarization). Respiratory parameters under baseline conditions and in response to 32% O2 for 10 min (relieving the ambient hypoxic stimulus) were measured by whole body plethysmography at 12 wk. Finally, we performed a survival analysis up to 600 days of age. Compared with HACont, HApNorm rats had reduced hematocrit and hemoglobin levels at all ages (both sexes); reduced right ventricular hypertrophy (both sexes); lower air space-to-tissue ratio in the lungs (males only); reduced CO2 production rate, but higher oxygen uptake (males only); and similar respiratory frequency, tidal volume, and minute ventilation. When breathing 32% O2, HApNorm male rats had a stronger decrease of minute ventilation than HACont. HApNorm rats had a marked tendency toward longer survival throughout the study. We conclude that exposure to ambient hypoxia during postnatal development in HA rats has deleterious consequences on acclimatization to hypoxia as adults. 2021-05-24T18:09:51Z 2021-05-24T18:09:51Z 2012 Article http://repositorio.umsa.bo/xmlui/handle/123456789/25261 en application/pdf J Appl Physiol. |
institution |
UMSA BO |
collection |
DSpace |
country |
Bolivia |
countrycode |
BO |
component |
Bibliográfico |
access |
En linea |
databasecode |
dig-umsa-bo |
tag |
biblioteca |
region |
America del Sur |
libraryname |
Sistema de Unidades de Información de UMSA |
language |
English |
topic |
DESARROLLO PULMONES RESPIRACIÓN DESARROLLO PULMONES RESPIRACIÓN |
spellingShingle |
DESARROLLO PULMONES RESPIRACIÓN DESARROLLO PULMONES RESPIRACIÓN Lumbroso, Delphine Lemoine, Alexandra Gonzales, Marcelino Villalpando, Gabriela Seaborn, Tommy Joseph, Vincent Life-long consequences of postnatal normoxia exposure in rats raised at high altitude |
description |
Abstract.
We tested the hypothesis that exposure of high-altitude (HA) rats to a period of postnatal normoxia has long-term consequences on the ventilatory and hematological acclimatization in adults. Male and female HA rats (3,600 m, PO2 100 Torr; La Paz, Bolivia) were exposed to normal room air [HA control (HACont)] or enriched oxygen (32% O2; PO2 160 Torr) from 1 day before to 15 days after birth [HA postnatal normoxia (HApNorm)]. Hematocrit and hemoglobin values were assessed at 2, 12, and 32 wk of age. Cardiac and lung morphology were assessed at 12 wk by measuring right ventricular hypertrophy (pulmonary hypertension index) and lung air space-to-tissue ratio (indicative of alveolarization). Respiratory parameters under baseline conditions and in response to 32% O2 for 10 min (relieving the ambient hypoxic stimulus) were measured by whole body plethysmography at 12 wk. Finally, we performed a survival analysis up to 600 days of age. Compared with HACont, HApNorm rats had reduced hematocrit and hemoglobin levels at all ages (both sexes); reduced right ventricular hypertrophy (both sexes); lower air space-to-tissue ratio in the lungs (males only); reduced CO2 production rate, but higher oxygen uptake (males only); and similar respiratory frequency, tidal volume, and minute ventilation. When breathing 32% O2, HApNorm male rats had a stronger decrease of minute ventilation than HACont. HApNorm rats had a marked tendency toward longer survival throughout the study. We conclude that exposure to ambient hypoxia during postnatal development in HA rats has deleterious consequences on acclimatization to hypoxia as adults. |
format |
Article |
topic_facet |
DESARROLLO PULMONES RESPIRACIÓN |
author |
Lumbroso, Delphine Lemoine, Alexandra Gonzales, Marcelino Villalpando, Gabriela Seaborn, Tommy Joseph, Vincent |
author_facet |
Lumbroso, Delphine Lemoine, Alexandra Gonzales, Marcelino Villalpando, Gabriela Seaborn, Tommy Joseph, Vincent |
author_sort |
Lumbroso, Delphine |
title |
Life-long consequences of postnatal normoxia exposure in rats raised at high altitude |
title_short |
Life-long consequences of postnatal normoxia exposure in rats raised at high altitude |
title_full |
Life-long consequences of postnatal normoxia exposure in rats raised at high altitude |
title_fullStr |
Life-long consequences of postnatal normoxia exposure in rats raised at high altitude |
title_full_unstemmed |
Life-long consequences of postnatal normoxia exposure in rats raised at high altitude |
title_sort |
life-long consequences of postnatal normoxia exposure in rats raised at high altitude |
publisher |
J Appl Physiol. |
publishDate |
2012 |
url |
http://repositorio.umsa.bo/xmlui/handle/123456789/25261 |
work_keys_str_mv |
AT lumbrosodelphine lifelongconsequencesofpostnatalnormoxiaexposureinratsraisedathighaltitude AT lemoinealexandra lifelongconsequencesofpostnatalnormoxiaexposureinratsraisedathighaltitude AT gonzalesmarcelino lifelongconsequencesofpostnatalnormoxiaexposureinratsraisedathighaltitude AT villalpandogabriela lifelongconsequencesofpostnatalnormoxiaexposureinratsraisedathighaltitude AT seaborntommy lifelongconsequencesofpostnatalnormoxiaexposureinratsraisedathighaltitude AT josephvincent lifelongconsequencesofpostnatalnormoxiaexposureinratsraisedathighaltitude |
_version_ |
1766395401895673856 |